Cholesterol-Lowering Nutraceuticals and Functional Foods

Chen, Zhenyu; Jiao, Rui; Ying, Ka

doi:10.1021/jf801566r

Cited by 234 publications

(191 citation statements)

References 157 publications

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“…nonconventional treatments for hypercholesterolemia, such as novel drugs based on a natural product, tea catechins (mainly gallate ester derivatives) have been tested successfully both in vitro and in vivo as cholesterol-lowering agents (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Globally, these fi ndings indicate that catechins exert concerted, multiple-level action involving the upregulation of the LDL receptor ( 15,24 ), the reduction of cholesterol absorption ( 16,26,27 ), and the modulation of both synthetic ( 15,28,29 ) and metabolic pathways ( 24 ).…”

mentioning

confidence: 99%

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Cuccioloni¹,

Mozzicafreddo²,

Spina

et al. 2011

Journal of Lipid Research

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mentioning

confidence: 99%

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Cuccioloni¹,

Mozzicafreddo²,

Spina

et al. 2011

Journal of Lipid Research

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“…However, there were no differences in the expression of CYP7A1 in the AG-diet, AP-diet and diabetic control groups. Because inhibitors of bile acid absorption in the small intestine are associated with the upregulation of CYP7A1 expression (Chen et al, 2008), the enhancement of bile acid excretion by AP would be attributable to its inhibitor effect of bile acid absorption.…”

Section: Resultsmentioning

confidence: 99%

Anti-diabetic Effects of Adlay Protein in Type 2 Diabetic db/db Mice

Watanabe

Kato

Ayugase

2012

FSTR

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We examined the effects of adlay protein concentrates (AP) on lipid metabolism and on in vivo oxidative stress in type 2 diabetic db/db mice. Mice were fed an AIN-93G diet containing either adlay grains (AG) or AP for 21 days. Plasma parameters, such as total cholesterol, arteriosclerotic index and thiobarbituric acid reactive substances (TBARS) concentration in the diabetic AP-fed group were lower than those in the diabetic control (AIN-93G) group. Concentrations of hepatic parameters, such as total cholesterol, triglyceride and TBARS levels, in the AP-fed group were lower than those in the diabetic control group. A pronounced improvement in lipid metabolism of the AP-fed group was observed when compared with the AG-fed group. It was deduced that excretion of bile acids and cholesterol in the feces of mice fed the AP diet abundant in resistant protein contributed to the suppression of plasma and hepatic cholesterol concentration in diabetic mice.

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“…Hypolipidemic nutraceuticals help improve serum lipid profiles as reducing total cholesterol, triglyceride, and low-density lipoprotein cholesterol, while elevating high-density lipoprotein cholesterol 33,34 . Possible mechanisms proposed for the hypocholesterolemic activity in kefir may involve different ways: (i) through the binding to and absorption into the cell before it can be absorbed into the body; (ii) producing free and deconjugating bile acids; (iii) inhibiting the enzyme HMG-CoA reductase.…”

Section: Hypocholesterolemic Effectmentioning

confidence: 99%

Kefir: a new role as nutraceuticals

Setyowati

Setyani

2009

JKKI

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Nutraceutical is the fusion of "nutrition" and pharmaceutical". This products, in broad, are food or part of food that provides medical or health benefits including the prevention and or treatment of a disease. Kefir is renowned nutraceutical dairy products produced through fermentation of bacteria and yeasts and naturally present in grains of kefir. The nutritional attributes are due to presence of vital nutrients such as carbohydrates, amino acids, proteins, minerals, phosphorus, vitamin, calcium, and certain biogenic compounds. Intestinal immunity, antimicrobial, anticarcinogenic, hypocholesterolemic effect, antibiabetic, effect on blood pressure level, antioxidant, wound healing, and lactose intoleran can be achieved using this products. The purpose of this review is to gather information about composition, methods of production, and therapeutic properties of kefir products to provide justification for its consumption. This review confirms that kefir can be a new role of nutraceutical products. karbohidrat, asam amino, protein, mineral, fosfor, vitamin, kalsium, dan senyawa biologis lainnya. Imunitas saluran cerna, antimikroorganisme, antikanker, efek hipokolesterolemia, antidiabetes, efek Nutraceutical merupakan perpaduan antara aspek "nutrisi (nutrition) dan farmasi (pharmaceutical)". Sediaan ini, secara luas, didefinisikan sebagai makanan atau bagian dari makanan yang memiliki manfaat terhadap kesehatan, yakni dalam hal pencegahan dan pengobatan penyakit. Kefir dikenal sebagai produk nutraceutical yang berasal dari fermentasi bakteri atau ragi yang secara alami terdapat pada tiap butiran kefir. Kandungan nutrisi pada kefir terdiri dari

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Cholesterol-Lowering Nutraceuticals and Functional Foods

Cited by 234 publications

References 157 publications

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase

Anti-diabetic Effects of Adlay Protein in Type 2 Diabetic db/db Mice

Kefir: a new role as nutraceuticals

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