Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion

Polichetti, Elisabeth; Diaconescu, N; Porte, P. Lechêne de la; Malli, Lina; Portugal, Henri; Pauli, A; Lafond, Huguette; Tuchweber, Béatriz; Yousef, Ibrahim M.; Chanussot, F.

doi:10.1079/bjn19960148

Cited by 44 publications

(30 citation statements)

References 32 publications

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“…The increase in bile flow in mice fed the LG ϩ 6% PC diet could be explained by the increase in biliary bile acid secretion (36). However, the increase in biliary PL secretion might be due to the fact that dietary PC can stimulate HDL-PC uptake by the liver, and thus PC can be released either from the preformed pool or from the newly synthesized pool (37). It has been observed that in model bile, PC containing saturated fatty acids can delay cholesterol crystallization time, while PC containing unsaturated fatty acids accelerates this process (38).…”

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Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis

Kasbo

Tuchweber

Perwaiz

et al. 2003

Journal of Lipid Research

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Cholesterol gallstones affect approximately 10-15% of the adult population in North America. Phosphatidylcholine (PC) is considered to be the main cholesterol solubilizer in bile. This study examined the effect of a PCenriched diet on gallstone incidence in mice susceptible to cholelithiasis. The result obtained showed that the feeding of a lithogenic (LG) diet for 4 weeks or 8 weeks resulted in cholesterol gallstone incidences of 47% and 89%, respectively. These gallstone incidences were either reduced or prevented when the LG diet was enriched with 2% or 6% PC, respectively. The cholesterol saturation index (CSI) was reduced only in mice fed with LG ؉ 6% PC diet as compared with mice fed the LG diet alone. However, in all groups, the CSI was significantly higher than in mice fed Purina chow diet. The biliary anionic polypeptide fraction (APF) was significantly increased in mice fed the LG ؉ 2% PC diet and was reduced in those fed with LG ؉ 6% PC diet. In conclusion, prevention or delay of gallstone formation was not due to a consistent effect on biliary lipid composition, suggesting a direct effect of PC on cholesterol solubilization and/or the effect of an additional nonlipid biliary component such as APF.

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confidence: 99%

Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis

Kasbo

Tuchweber

Perwaiz

et al. 2003

Journal of Lipid Research

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“…The amount of PC secreted into bile is influenced by several factors (20): 1) the intracanalicular bile salt concentration (21,22); 2) the hydrophobicity of the intracanalicular bile salts (23); 3) the magnitude of the bile salt-independent fraction of the bile flow (24); 4) the concentration of hydrophilic organic anions (25); 5) the abundance of Mdr2 at the bile canalicular membrane (3,16,26); and 6) the lipid composition of the bile canalicular membrane (27)(28)(29)(30). Taurocholate feeding did not induce detectable changes in Mdr2 mRNA or protein levels (Fig.…”

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confidence: 99%

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

Verkade

Havinga

Shields

et al. 2007

Journal of Lipid Research

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The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC. We evaluated whether the PEMT pathway is quantitatively important for biliary PC secretion in mice under various experimental conditions. Biliary bile salt and PC secretion were determined in mice in which the gene encoding PEMT was inactivated (Pemt 2/2 ) and in wild-type mice under basal conditions, during acute metabolic stress (intravenous infusion of the bile salt tauroursodeoxycholate), and during chronic metabolic stress (feeding a taurocholatecontaining diet for 1 week). The activity of CTP:phosphocholine cytidylyltransferase, the rate-limiting enzyme of PC biosynthesis via the CDP-choline pathway, and the abundance of multi-drug-resistant protein 2 (Mdr2; encoded by the Abcb4 gene), the canalicular membrane flippase essential for biliary PC secretion, were determined. Under basal conditions, Pemt 2/2 and wild-type mice exhibited similar biliary secretion rates of bile salt and PC (?145 and ?28 nmol/min/100 g body weight, respectively). During acute or chronic bile salt administration, the biliary PC secretion rates increased similarly in Pemt 2/2 and control mice. Mdr2 mRNA and protein abundance did not differ between Pemt 2/2 and wild-type mice. The cytidylyltransferase activity in hepatic lysates was increased by 20% in Pemt 2/2 mice fed the basal (bile salt-free) diet (P , 0.05). We conclude that the biosynthesis of PC via the PEMT pathway is not quantitatively essential for biliary PC secretion under acute or chronic bile salt administration.-Verkade, H.

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“…Blood cholesterol concentration is an important risk factor for the development of atherosclerosis, and soy lecithin has hypocholesterolemic properties in animals and humans (Jimenez et al 1990;Polichetti et al 1996). However, the underlying mechanism of the cholesterol lowering effect of soy lecithin, as well as that of COS, has not been elucidated.…”

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Effect of lecithin with or without chitooligosaccharide on the growth performance, nutrient digestibility, blood metabolites and pork quality of finishing pigs

Kim¹,

Shinde²,

Chae³

2008

Can. J. Anim. Sci.

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. 2008. Effect of lecithin with or without chitooligosaccharide on the growth performance, nutrient digestibility, blood metabolites and pork quality of finishing pigs. Can. J. Anim. Sci. 88: 283Á292. Two experiments were conducted to evaluate the effect of dietary lecithin with or without chitooligosaccharide (COS) on the performance, blood metabolites, pork cholesterol, fatty acid composition and quality of finishing pigs. In exp. 1, 36 pigs (Landrace )Yorkshire )Duroc, 84.590.60 kg initial body weight) were fed lecithin at 0, 2.5 or 5.0% of the diet. Lecithin improved average daily gain (16%) and feed conversion ratio, and did not affect apparent nutrient digestibility. On day 28, lecithin decreased serum total and low density lipoprotein (LDL) cholesterol (34 and 77%, P 00.016), and increased serum triglyceride (P 00.048). Lecithin did not affect carcass characteristics and pork quality, but increased myristic and alinolenic acid and reduced palmitoleic acid in pork. Experiment 2 involved 108 pigs (85.090.76 kg initial body weight) in a 2 )2 factorial arrangement of treatments, wherein two levels of lecithin (low, 2.5 and high, 5.0%) and COS (0.0 and 0.1%) were used. Addition of COS in diets containing lecithin reduced pork cholesterol (16.4%) and oleic acid (28.3%), and did not affect performance, nutrient digestibility, blood metabolites and pork quality. In conclusion, these results suggest that lecithin improved the growth performance of finishing pigs and inclusion of COS reduced the amount of cholesterol in pork.Key words: Lecithin, COS, performance, nutrient digestibility, pork quality Kim, W.-T., Shinde, P. et Chae, B. J. 2008. Incidence de la le´cithine contenant ou pas des chito-oligosaccharides sur la croissance des porcs de finition, la digestibilite´des e´le´ments nutritifs, les me´tabolites du sang et la qualite´de la viande. Can. J. Anim. Sci. 88: 283Á292. Les auteurs ont effectue´deux expe´riences afin d'e´valuer l'impact de la le´cithine contenant ou pas des chito-oligosaccharides (COS) sur la croissance des porcs de finition, les me´tabolites du sang, la concentration de choleste´rol dans la viande, la composition des acides gras et la qualite´de la viande. Dans la premie`re, ils ont donne´a3 6 porcs (Landrace )Yorkshire )Duroc, 84,590,60 kg de poids initial) une ration contenant 0, 2,5 ou 5,0 % de le´cithine. La le´cithine augmente le gain quotidien moyen (16 %) et l'indice de consommation sans modifier la digestibilite´apparente des nutriments. Au 28 e jour, la le´cithine avait diminue´la concentration de choleste´rol total et de choleste´rol LDL dans le sang (34 et 77 %, P00,016) et augmente´celle de triglyce´rides (P 00,048). La le´cithine n'a aucune incidence sur les proprie´te´s de la carcasse ni sur la qualite´de la viande, mais elle accroıˆt la concentration d'acide myristique et d'acide alinole´nique tout en diminuant celle d'acide palmitole´ique dans la viande. La deuxie`me expe´rience portait sur 108 porcs (85,090,76 kg de poids initial) re´partis en une disposition factorielle 2...

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Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion

Cited by 44 publications

References 32 publications

Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis

Phosphatidylcholine-enriched diet prevents gallstone formation in mice susceptible to cholelithiasis

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

Effect of lecithin with or without chitooligosaccharide on the growth performance, nutrient digestibility, blood metabolites and pork quality of finishing pigs

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