Cholesterol-lowering effect of plant sterols

Atividade farmacológica de extratos de abacate (Percea americana miller), acerola (Malpighia emarginata d.c.) e do flavonóide naringina no tratamento da dislipidemia

“…Também esse efeito pode ser atribuído a um aumento da expressão do receptor da LDL no fígado (MIETTINEN; GYLLING, 1999;WESTER, 2000).…”

Lipid-lowering Activity of Natural and Semi-Synthetic Sterols and Stanols

“…Therefore, these compounds are of interest as therapeutic agents to reduce plasma cholesterol. However, the use of plant sterols/stanols as supplements or ingredients for functional foods is restricted by their crystalline nature, low solubility in fats, insolubility in water, high melting point of 140-150 °C, in addition to poor palatability (15)(16)(17)(18). Several attempts have been made to enhance the bioavailability of crystalline sterols by reducing the crystal size or by the use of microcrystalline suspensions (18,19).…”

“…Other approaches involve modification of phytosterols by esterification with fatty acids from vegetable (20,21) or fish oils (22,23), which leads to synthesis of semisynthetic sterols. Such modification can provide an easy way of introducing the daily amount of phytosterols required for optimal reduction of cholesterol (17). ________________________________________ Esterification not only changes the physical properties, but also can improve the efficacy of plant sterols since it allows greater solubilisation within food products and optimal dispersion within mixed micelles during intestinal absorption of lipids (17,24).…”

“…Such modification can provide an easy way of introducing the daily amount of phytosterols required for optimal reduction of cholesterol (17). ________________________________________ Esterification not only changes the physical properties, but also can improve the efficacy of plant sterols since it allows greater solubilisation within food products and optimal dispersion within mixed micelles during intestinal absorption of lipids (17,24). The first commercial application of fatty acid esterification of plant stanols was in the form of margarine (Benecol ® ) in 1995 in Finland by Raisio Benecol Ltd (12,17).…”

Simple Techniques to Increase the Production Yield and Enhance the Quality of Organic Rice Bran Oils

“…γ-Oryzanol and phytosterols have the capacity to lower blood cholesterol and decrease cholesterol absorption. Tocotrienols and γ-oryzanol are known as powerful antioxidants and this is associated with the prevention of cardiovascular diseases and some cancers [1][2][3][4][5][6] .…”