Cholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution

Odabaşı, Mehmet; Uzun, Lokman; Baydemir, Gözde; Aksoy, Neşe Hayat; Acet, Ömür; Erdönmez, Demet

doi:10.1016/j.colsurfb.2017.12.033

Cited by 36 publications

(11 citation statements)

References 29 publications

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“…The synthesized device was able t Also, different membranes were prepared for application in the biomedical field or for various biotechnological uses, on account of their biomimetic behavior. For example, cholesterol removal studies using MIMs [59,60] have become more attractive to overcome its deleterious effects on human health. Thus, Niesa et al [60] developed a MIM obtained by in situ photopolymerization for extraction of cholesterol from blood samples.…”

Section: Pharmaceutical and Food Applicationsmentioning

confidence: 99%

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

et al. 2020

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This review describes the recent advances from the past five years concerning the development and applications of molecularly imprinted membranes (MIMs) in the field of sample treatment and separation processes. After a short introduction, where the importance of these materials is highlighted, a description of key aspects of membrane separation followed by the strategies of preparation of these materials is described. The review continues with several analytical applications of these MIMs for sample preparation as well as for separation purposes covering pharmaceutical, food, and environmental areas. Finally, a discussion focused on possible future directions of these materials in extraction and separation field is also given.

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Section: Pharmaceutical and Food Applicationsmentioning

confidence: 99%

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

et al. 2020

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“…Milk [41] CHO-imprinted poly(GMA-N-methacryloyl-(L)-tyrosine microspheres embedded p(HEMA) cryogels 80% and 42.2 mg/g Milk and IMS [42] Cholesterol imprinted poly(HEMA-N-methacryloyl-(L)-tyrosine methylester) 7.7 mg/g IMS [43] CHO imprinted poly(HEMA-methacryloyloamidotryphan) particles embedded composite membrane 9.24 mg/g IMS [44] Cholesterol imprinted poly(HEMA-N-methacryloyl-(L)-phenylalanine methylester) analogues of CHO. Artificial human plasma was spiked with estrone, estradiol, progesterone and testosterone as all components would be at some concentration with CHO.…”

Section: 8%mentioning

confidence: 99%

Cholesterol Adsorption from Artificial Human Plasma with Molecular Imprinted Polymeric Nanostructures

Inanan

Tüzmen²

2018

HJBC

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Ö Z B u çalışma, farklı kalıp-monomer oranları kullanılarak hazırlanmış MIP nanoyapıları ile yapay insan plazmasından kolesterol adsorpsiyonunu sunmaktadır. CP'nin adsorpsiyon kapasitesi C3P ve CP3'e göre sırayla %19,9 ve %16,1 daha yüksektir ve CP'nin adsorpsiyon kapasitesi NIP nanoyapılarına göre önemli derecede yüksektir. Tüm seçicilik katsayıları ve bağıl seçicilik değerleri yapay insan plazması için 1'den büyüktür. Optimum koşullarda, hiperkolesterolemik plazmadan oldukça yüksek kolesterol (%95.33) adsorplanmıştır. Anahtar KelimelerKolesterol; moleküler baskılama; plazma; nanoyapılar. A B S T R A C TT his study reports cholesterol adsorption from artificial human plasma using MIP nanostructures prepared with different template:monomer ratios. The adsorption capacity of CP is 19.9% and 16.1% higher than those of C3P and CP3, respectively and adsorption capacity of CP is significantly higher than NIP nanostructures. All selectivity coefficients and relative selectivity values were higher than 1 for artificial human plasma. Under optimum conditions, considerably high cholesterol was adsorbed from hypercholesterolemic plasma (95.33 %).

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“…One of the methods to create highly selective polymer sorbents is molecular imprinting [4,5]. Molecular imprinting consists of forming a polymer network in the presence of template molecules.…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Synthesis Method on Physicochemical Properties of Selective Granular Polymer Sorbents

Osipenko

Garkushina

2022

Polymers

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Investigation of the effect of the polymer synthesis method on physicochemical properties of sorbents is one of the topical problems in the chemistry of macromolecular compounds that has high scientific and practical interest. Determination of the optimal synthesis method will make it possible to create sorbents with physicochemical properties that led to the realization of effective sorption. In this work, we investigated the effect of synthesis methods (Pickering emulsion polymerization and precipitation polymerization in solution) of granular polymers based on 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate on physicochemical and sorption properties. The synthesis by Pickering emulsion polymerization led to improvement of the n-propyl alcohol diffusion into the polymer network and to the formation of more homogeneous and structurally stable polymer networks. Creating selective polymer networks by Pickering emulsion polymerization compared to precipitation polymerization in solution led to an increase in porosity, creation of more segregated surface of granules, improvement of binding sites availability at the temperature of 37 °C, and formation of the homogeneous sorption surface with high affinity to target molecules at 25 °C and 37 °C. Selective polymers synthesized by both polymerization methods had the largest values of available sorption surfaces areas for target molecules at 37 °C.

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Cholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution

Cited by 36 publications

References 29 publications

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

Recent Advances in Molecularly Imprinted Membranes for Sample Treatment and Separation

Cholesterol Adsorption from Artificial Human Plasma with Molecular Imprinted Polymeric Nanostructures

The Effect of the Synthesis Method on Physicochemical Properties of Selective Granular Polymer Sorbents

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