Cholesterol gallstone disease: focusing on the role of gallbladder

Chen, Yongsheng; Kong, Jing; Wu, Shuodong

doi:10.1038/labinvest.2014.140

Cited by 46 publications

(25 citation statements)

References 101 publications

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“…Gallbladder conditions reportedly affect gallstone formation. 55 In fact, CCD loading in control mice induced a white cloudy gallbladder appearance (Supplementary Figure 1E and Figure 1E). Histologic analyses of the gallbladders from CCD-fed control mice showed that wall thicknesses were increased and that infiltration of inflammatory cells had occurred ( Supplementary Figure 6A and B).…”

Section: Hepatocyte-selective Knockout Of Hif1a Affects the State Of mentioning

confidence: 94%

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones

et al. 2017

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Section: Hepatocyte-selective Knockout Of Hif1a Affects the State Of mentioning

confidence: 94%

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones

et al. 2017

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“…However, recent studies have increased our knowledge of GB function and its essential role in the development of cholesterol gallstone disease. 37 Thus, when conducting future epidemiological studies, it may be preferable to analyze cholecystectomized and gallstone patients separately with regards to their risk for developing MetS.…”

Section: Cholecystectomy and Mets Componentsmentioning

confidence: 99%

Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

Chen

Tian

2018

Laboratory Investigation

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Cholecystectomy has long been regarded as a safe procedure with no deleterious influence on the body. However, recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, we describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated, including visceral obesity, dyslipidemia, elevated blood pressure, impaired fasting glucose, and insulin resistance. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.

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“…[1] It is a multifactorial disease and has several risk factors including sex, age, genetic factors, race, obesity, rapid weight loss, diet, alcohol consumption, diabetes mellitus (DM), hyperlipidemia, drug use, and pregnancy. [2]…”

Section: Introductionmentioning

confidence: 99%

The association between gallstone disease and plaque in the abdominopelvic arteries

et al. 2017

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Background:The aim of this study was to assess the atheromatous plaque, in the abdominopelvic arteries as a marker of cardiac risk in patients with or without gallstone disease (GD).Materials and Methods:A total of 136 patients were enrolled in this cross-sectional study. Forty-eight patients had GD and the remaining 88 patients did not. The presence or absence of gallstones was noted during abdominal ultrasonography while vascular risk factors such as plaque formation, intima-media thickness, plaque calcification, mural thrombus, stenosis, aneurysm, and inflammation were recorded during an abdominopelvic computed tomography scan. In addition, percentage of the abdominopelvic aorta surface covered by atheromatous plaque was calculated.Results:The mean age of patients with GD and without GD was 50.81 ± 16.20 and 50.40 ± 12.43, respectively. Patients with GD were more likely to have diabetes mellitus, a higher body mass index (BMI) (P < 0.001), and higher cholesterol (P < 0.01), and low-density lipoprotein-cholesterol (P < 0.02) levels. No significant differences were found between the groups regarding other atherosclerotic risk factors. Patients with GD had significantly higher rates of the vascular risk factors as intima-media thickness, plaque formation, calcification, aneurysm, mural thrombosis, stenosis, and inflammation in all abdominal arterial segments other than aneurysm in the femoral arteries. In addition, patients with GD had severe atheromatous plaques in the abdominal aorta, common iliac, external iliac, and common femoral artery (CFA). In patients with GD, parameters of age, BMI, and systolic and diastolic blood pressure were all correlated with the severity of the atheromatous plaque in abdominal aorta, common iliac, external iliac, and CFA.Conclusion:We demonstrated a direct relationship between GD and abdominopelvic atheromatous plaque, which is a marker for increased cardiovascular risk, for the first time in the literature. Patients with GD exhibit greater abdominopelvic atherosclerosis and therefore, have a higher risk of cardiovascular disease.

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Cholesterol gallstone disease: focusing on the role of gallbladder

Cited by 46 publications

References 101 publications

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones

Cholecystectomy as a risk factor of metabolic syndrome: from epidemiologic clues to biochemical mechanisms

The association between gallstone disease and plaque in the abdominopelvic arteries

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