Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

Guilbaud, Emma; Barouillet, Thibault; Ilié, Marius; Borowczyk, C.; Ivanov, Stoyan; Sarrazy, Vincent; Vaillant, Nathalie; Ayrault, Marion; Castiglione, Alexia; Rignol, Guylene; Brest, Patrick; Bazioti, Venetia; Zaitsev, Konstantin; Lebrigand, Kévin; Dussaud, Sébastien; Magnone, Virginie; Bertolotto, Corine; Marchetti, Sandrine; Irondelle, Marie; Goldberg, Ira J.; Huby, Thierry; Westerterp, Marit; Gautier, Emmanuel L.; Mari, Bernard; Barbry, Pascal; Hofman, Paul; Yvan‐Charvet, Laurent

doi:10.1016/j.stem.2023.05.005

Cited by 5 publications

(3 citation statements)

References 58 publications

(101 reference statements)

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“…Therefore, cholesterol removal via the promotion of the cholesterol efflux pathway could present a potential strategy to limit tumor growth. 22 2.3. Promotion of Cholesterol Biosynthesis by Phytochemicals.…”

Section: -Hydroxy-3-methylglutaryl-coa Synthase 1 (Hmgcs1) and 3-hydr...mentioning

confidence: 99%

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Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Weerawatanakorn,

Kamchonemenukool,

Koh

et al. 2024

J. Agric. Food Chem.

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Although cholesterol plays a key role in many physiological processes, its dysregulation can lead to several metabolic diseases. Statins are a group of drugs widely used to lower cholesterol levels and cardiovascular risk but may lead to several side effects in some patients. Therefore, the development of a plant-based therapeutic adjuvant with cholesterol-lowering activity is desirable. The maintenance of cholesterol homeostasis encompasses multiple steps, including biosynthesis and metabolism, uptake and transport, and bile acid metabolism; issues arising in any of these processes could contribute to the etiology of cholesterolrelated diseases. An increasing body of evidence strongly indicates the benefits of phytochemicals for cholesterol regulation; traditional Chinese medicines prove beneficial in some disease models, although more scientific investigations are needed to confirm their effectiveness. One of the main functions of cholesterol is bile acid biosynthesis, where most bile acids are recycled back to the liver. The composition of bile acid is partly modulated by gut microbes and could be harmful to the liver. In this regard, the reshaping effect of phytochemicals on gut microbiota has been widely reported in the literature for its significance. Therefore, we reviewed studies conducted over the past 5 years elucidating the regulatory effects of phytochemicals or herbal medicines on cholesterol metabolism. In addition, their effects on the recomposition of gut microbiota and bile acid metabolism due to modulation are discussed. This review aims to provide novel insights into the treatment of cholesterol dysregulation and the anticipated development of natural-based compounds in the near and far future.

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Section: -Hydroxy-3-methylglutaryl-coa Synthase 1 (Hmgcs1) and 3-hydr...mentioning

confidence: 99%

“…Studies have also shown that KRAS mutations in lung adenocarcinomas stop cholesterol efflux, thereby promoting tumor growth. Therefore, cholesterol removal via the promotion of the cholesterol efflux pathway could present a potential strategy to limit tumor growth …”

Section: Regulation Of Cholesterol Homeostasismentioning

confidence: 99%

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Weerawatanakorn,

Kamchonemenukool,

Koh

et al. 2024

J. Agric. Food Chem.

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“…Therefore, blocking cholesterol consumption or transport hampers tumor growth and invasion in various cancers [ 18 , [22] , [23] , [24] , [25] , [26] ]. In the tumor microenvironment, cholesterol metabolism seems to be associated with immune function as well [ 20 , [27] , [28] , [29] , [30] , [31] , [32] ]. The biosynthesis of cholesterol is jointly completed by SREBP2 and its regulated genes, which are significantly upregulated under lipid or oxygen limiting conditions, promoting tumor growth [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

The combined characteristics of cholesterol metabolism and the immune microenvironment may serve as valuable biomarkers for both the prognosis and treatment of hepatocellular carcinoma

Bai

2023

Heliyon

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Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

Li,

Shen,

Yang

et al. 2024

Advanced Materials

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Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, and starvation therapy, have been applied to cancer treatment, their limited therapeutic effect, severe side effects, and unsatisfactory drug release behavior need to be carefully considered. Thus, there is an urgent need to develop efficient drug delivery strategies for improving cancer treatment efficacy and realizing on‐demand drug delivery. Notably, pillararenes, as an emerging class of supramolecular macrocycles, possess unique properties of highly tunable structures, superior host–guest chemistry, facile modification, and good biocompatibility, which have been widely used in cancer therapy to achieve controllable drug release and reduce the toxic side effects on normal tissues under various internal/external stimuli conditions. This review summarizes the recent advance of stimuli‐responsive supramolecular delivery systems (SDSs) based on pillararenes for tumor therapy from the perspectives of different assembly methods and hybrid materials, including molecular‐scale SDSs, supramolecular nano self‐assembly delivery systems, and nanohybrid SDSs. Moreover, the prospects and critical challenges of stimuli‐responsive SDSs based on pillararenes for cancer therapy are also discussed.This article is protected by copyright. All rights reserved

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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

Cited by 5 publications

References 58 publications

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

The combined characteristics of cholesterol metabolism and the immune microenvironment may serve as valuable biomarkers for both the prognosis and treatment of hepatocellular carcinoma

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

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