Cholesterol-Dependent Membrane Deformation by Metastable Viral Capsids Facilitates Entry
Mengchi Jiao,
Pranav Danthi,
Yan Yu
Abstract:Non-enveloped viruses employ unique entry mechanisms to breach and infect host cells. Understanding these mechanisms is crucial for developing antiviral strategies. Prevailing perspective suggests that non-enveloped viruses release membrane lytic peptides to breach host membranes. However, the precise involvement of the viral capsid in this entry remains elusive. Our study presents direct observations elucidating the dynamically distinctive steps through which metastable reovirus capsids disrupt host lipid mem… Show more
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