Cholesteatoma ? A Potential Consequence of Chronic Middle Ear Inflammation

Frickmann, Hagen

doi:10.4172/2161-119x.s5-001

Cited by 15 publications

(18 citation statements)

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“…Tipični stečeni holesteatom srednjeg uha može dovesti do koštane resorpcije temporalne kosti, destrukcije osikularnog lanca i otičke kapsule, infiltracije mastoidnog nastavka, perforacije bubne opne, otoreje, konduktivne i senzorineuralne nagluvosti, vestibularne disfunkcije, neuropatija, sistemske infekcije, hroničnog bola i izmijenjenog mentalnog statusa [1,4].…”

Section: Uvodunclassified

Destrukcija kosti kod holesteatoma srednjeg uha

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et al. 2017

Biomedicinska istraž.

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¹Klinika za bolesti uha, grla i nosa, Univerzitetski klinički centar Republike Srpske, Banja Luka, Republika Srpska, Bosna i Hercegovina 2 Medicinski fakultet, Univerzitet u Banjoj Luci, Banja Luka, Republika Srpska, Bosna i Hercegovina 3 Univerzitetska bolnica Foča, Republika Srpska, Bosna i Hercegovina Kratak sadržajUvod. Holesteatom se definiše kao cistična, ekspanzivna lezija temporalne kosti, čiju glavnu osobinu karakteriše progresivan rast s erozijom okolne kosti. Cilj istraživanja je bio da se ispita status osikularnog lanca i koštanih zidova kavuma timpani kod ispitanika sa holesteatomom srednjeg uha.Metode. Studija je obuhvatila 100 ispitanika, oba pola, u dobi od 16 do 84 godine, operativno tretiranih zbog hronične upale srednjeg uha u Klinici za bolesti uha, grla i nosa Univerzitetskog kliničkog centra Republike Srpske, u razdoblju od 2015. do 2016. godine. Ispitanici su podijeljeni u dvije grupe od po 50 ispitanika prema prisustvu holesteatoma: eksperimentalnu grupu sa holesteatomom i kontrolnu grupu bez holesteatoma. Intraoperativnom eksploracijom ispitan je status osikularnog lanca i koštanih zidova kavuma timpani.Rezultati. U kontrolnoj grupi bez holesteatoma statistički značajno veći broj ispitanika je imao očuvan anatomski integritet koštanih zidova kavuma timpani (47/50; χ 2 = 38,720; p < 0,001) za razliku od eksperimentalne grupe gdje su statistički značajno učestaliji bili ispitanici s destrukcijom pomenutih anatomskih struktura (41/50; χ 2 = 22,224; p < 0,001). Utvrđena je statistički značajna razlika između grupe sa i bez holesteatoma u odnosu na status osikularnog lanca. U eksperimentalnoj grupi je zabilježena statistički znača-jno veća učestalost ispitanika (36%) s nedostatkom inkusa i drške maleusa i erozijom suprastruktura stapesa, a u kontrolnoj statistički značajno veća učestalost ispitanika (76%) s očuvanim osikularnim lancem.Zaključak. Destrukcija koštanih zidova kavuma timpani i osikularnog lanca je bila statistički značajno učestalija kod ispitanika sa holesteatomom srednjeg uha. Prema stepenu destrukcije osikularnog lanca, statistički najzastupljenija je bila kategorija ispitanika s nedostatkom inkusa, drške maleusa, kao i erozijom suprastruktura stapesa.Ključne riječi: osikularni lanac, holesteatom, upala srednjeg uha

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Destrukcija kosti kod holesteatoma srednjeg uha

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“…acquired. An annual incidence of acquired cholesteatomas is 3 in 100,000 in childhood and 9.2 in 100,000 in adult population, predominantly in males [4][5][6]. Cholesteatoma causes destruction of the temporal bone due to mechanical pressure, enzymatically mediated bone resorption and promotion of acute and chronic infections [7,8].…”

Section: Introductionmentioning

confidence: 99%

Expression of tumor necrosis factor-alpha receptor 2 and interleukin-1 in middle ear cholesteatoma

et al. 2021

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Background/Aim. Cholesteatoma is characterized by progressive growth with erosion of surrounding bone due to pressure effects, enzymatic activity and activation of osteoclasts. Objective of study was to examine the expression levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1) receptors in chronic otitis media (COM) with and without acquired cholesteatoma and correlate it with the degree of bone destruction. Methods. The study included 178 patients of both sexes, aged 5-75 years, who underwent microsurgical treatment for COM, with and without cholesteatoma at the Ear, Nose and Throat Department, University Clinical Center of Republika Srpska (UCC RS), Banjaluka from 2015 to 2018. Based on cholesteatoma presence patients were divided in two groups: with cholesteatoma (CCOM) (n=97) and without cholesteatoma (COMWC) (n=81). Samples of cholesteatoma perimatrix in CCOM group and tympanic cavity inflamed mucosa in COMWC group were collected intraoperatively. Intraoperative exploration of the middle ear included the status of ossicular chain, individual ossicles, osseous walls of external auditory canal (EAC) and tympanic cavity. Receptor expression levels of tumor necrosis factor-R2 (TNF-R2) and IL-Key words: chronic otitis media; cholesteatoma; bone destruction; inflammatory mediators. APSTRAKT Uvod / Cilj rada. Holesteatom karakteriše progresivni rast s erozijom okolnih koštanih struktura usljed efekta pritiska, enzimatske aktivnosti i aktivacije osteoklasta. Cilj studije je bio da se utvrde nivoi ekspresije receptora faktora nekroze tumora-alfa (TNF-α) i interleukina-1 (IL-1) kod hroničnog otitis media (HOM), sa i bez stečenog holesteatoma, i njihova korelacija sa stepenom koštane destrukcije. Metode. Studija je uključila 178 pacijenata oba pola, od 5 do 75 godina, podvrgnutih mikrohirurškom liječenju zbog HOM, sa i bez holesteatoma, u Klinici za bolesti uva, grla i nosa Univerzitetskog kliničkog centra Republike Srpske (UKC RS), Banja Luka od 2015. do 2018. godine. Na osnovu prisustva ili odsustva holesteatoma, pacijenti su podijeljeni u 2 grupe: s holesteatomom (n=97) i bez holesteatoma (n=81). Uzorci perimatriksa holesteatoma (grupa s holesteatomom) i inflamirane sluznice kavuma timpani (grupa bez holesteatoma) su intraoperativno uzeti. Intraoperativna eksploracija srednjeg uha je uključivala provjeru stanja osikularnog lanca, pojedinih osikula, koštanih zidova spoljašnjeg slušnog kanala i kavuma timpani, kao i susjednih anatomskih struktura. Nivoi ekspresije receptora TNF-R2 i IL-1 su određeni imunohistohemijskom analizom intraoperativno dobijenih tkivnih uzoraka. Rezultati. Korelacija između stepena osteodestrukcije i prisustva holesteatoma je bila statistički značajna. Visoki nivoi ekspresije TNF-R2 i IL-1 su bili najučestaliji u grupi pacijenata s holesteatomom, koji su imali osteodestrukciju u odnosu na grupu pacijenata bez holesteatoma s opisanom patomorofološkom promjenom. Vjerovatnoća osteodestrukcije zidova spoljašnjeg slušnog kanala i kavuma timpani je bila značajno veća kod pacijenat...

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“…The etiology of cholesteatoma is not yet completely understood, but various studies have revealed that a number of factors cooperate in a synergistic way to cause the forming of this nonneoplastic keratinizing lesion, which is characterized by enhanced proliferation of epithelial cells with aberrant morphologic characteristics [ 1 , 5 – 7 ]. These factors include persistent microbial infection resulting in chronic inflammation, consecutive invasion by cells of the immune system, Eustachian tube dysfunction, aggregation of cellular debris, and increased viscosity of middle ear effusions, in-growth of blood vessels, auditory ossicle resorption, and epithelial hyperplasia [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation

Masanta

Hinz

Zautner

2015

BioMed Research International

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Chronic inflammation, which is caused by recurrent infections, is one of the factors contributing to the pathogenesis of cholesteatoma. If reimplantation of autologous ossicles after a surgical intervention is intended, inactivation of planktonic bacteria and biofilms is desirable. High hydrostatic pressure treatment is a procedure, which has been used to inactivate cholesteatoma cells on ossicles. Here we discuss the potential inactivating effect of high hydrostatic pressure on microbial pathogens including biofilms. Recent experimental data suggest an incomplete inactivation at a pressure level, which is tolerable for the bone substance of ossicles and results at least in a considerable reduction of pathogen load. Further studies are necessary to access how far this quantitative reduction of pathogens is sufficient to prevent ongoing chronic infections, for example, due to forming of biofilms.

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Cholesteatoma ? A Potential Consequence of Chronic Middle Ear Inflammation

Abstract: Although cholesteatoma is considered to be a benign process, spreading to surrounding structures may lead to severe, sometimes even life-threatening complications [19]. Most of the complications are infectious [4]. Advanced disease typically occurs in older children [45].

Cited by 15 publications

References 83 publications

Destrukcija kosti kod holesteatoma srednjeg uha

Destrukcija kosti kod holesteatoma srednjeg uha

Expression of tumor necrosis factor-alpha receptor 2 and interleukin-1 in middle ear cholesteatoma

Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation

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