Cholestatic Liver Diseases and Health-Related Quality of Life

Younossi, Zobair M.; Kiwi, Michelle L; Boparai, Navdeep; Price, Lori Lyn; Guyatt, Gordon

doi:10.1111/j.1572-0241.2000.01774.x

Cited by 142 publications

(61 citation statements)

References 15 publications

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“…[4][5][6] Given this profoundly debilitated state, improving quality of life with liver transplantation takes on increasing importance. [21][22][23][24][25][26] Accordingly, an integrated approach to liver transplantation that combines clinical outcomes (improving survival, nutritional state) with socioeconomic outcomes (health-related quality of life, cost) is advocated by many investigators.…”

Section: Discussionmentioning

confidence: 99%

“…We compared CLDQ scores of patients awaiting OLT with previously reported norms. 6,17 Patients who underwent OLT were also administered postoperative questionnaires, and additional post-OLT data were obtained. These included total hospital charges associated with the episode of transplantation (technical and service charges, excluding professional charges) and length of stay recorded in our Unified Transplant Database.…”

Section: Questionnairesmentioning

confidence: 99%

“…This study systematically evaluates the impact of OLT on health-related quality of life. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] …”

mentioning

confidence: 99%

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Impact of liver transplantation on health-related quality of life

Younossi¹,

McCormick²,

Price³

et al. 2000

Liver Transpl

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This study is designed to measure the impact of orthotopic liver transplantation (OLT) on patients' health-related quality of life. Two types of health-related quality-of-life questionnaires were administered at baseline and after OLT: generic (Medical Outcomes Study Short Form 36) and liver specific (Chronic Liver Disease Questionnaire). We also recorded clinical, demographic, and laboratory data. Pre-OLT scores of liver transplant candidates were compared with those of the general population and patients with congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD). Thirty-seven liver transplant candidates were evaluated: 25 men and 12 women; age, 50.2 ؎ 12 years; Child's class A, 3 patients; class B, 30 patients; class C, 4 patients; and galactose elimination capacity, 277 ؎ 81. Health-related quality-of-life scores for patients awaiting liver transplants were significantly lower than those for patients with COPD and CHF and those in the general population. Sex and cause of liver disease did not affect the scores. There was a weak but significant inverse correlation between some aspects of health-related quality of life and both age (r ‫؍‬ -0.31 to -0.34) and worsening of the Child-Pugh score (r ‫؍‬ -0.32 to -0.43). All measured aspects of healthrelated quality of life significantly improved after OLT, and mental health scores were indistinguishable from the population norms. Similar improvements were evident in physical and disease-specific aspects of health-related quality of life, but some residual dysfunction persisted. (Liver Transpl 2000;6:779-783.) C hronic liver disease and its complications are the ninth leading cause of death in the United States. In addition to its effect on mortality, end-stage liver disease has a profoundly negative impact on morbidity and health-related quality of life. Orthotopic liver transplantation (OLT), the established standard treatment for patients with end-stage liver disease, has a 1-year survival rate of 80% to 85%. An integrated approach to health care developed over the past 2 decades combines such traditional biomedical outcomes of OLT as survival with such socioeconomic outcomes as health-related quality of life. This study systematically evaluates the impact of OLT on health-related quality of life. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]

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Section: Discussionmentioning

confidence: 99%

Section: Questionnairesmentioning

confidence: 99%

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Impact of liver transplantation on health-related quality of life

Younossi¹,

McCormick²,

Price³

et al. 2000

Liver Transpl

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“…16 However, poor health-related quality of life and possible significant psychological disturbances causing sleep deprivation, depression, and suicidal ideas 16,20,21 might justify, in the most severe cases of intractable pruritus, more aggressive treatment, including liver transplantation, 22 charcoal hemoperfusion, and the recently introduced MARS. 10,[23][24][25] Of note, the effect of MARS on hydrophobic and hydrophilic bile acids has never been differentiated.…”

Section: A Molecular Adsorbent Recirculating System (Mars)mentioning

confidence: 99%

Effect of molecular adsorbent recirculating system in hepatitis C virus-related intractable pruritus

Doria

Mandalà

Smith

et al. 2003

Liver Transplantation

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“…This is particularly important in a condition such as PBC where significant impairment of QOL is recognised, typically resulting from symptoms such as fatigue, which are unrelated to disease severity. [3][4][5][6] The importance of improvement in QOL as a goal of therapy in its own right, is made all the more pertinent by the observation, made so elegantly by Combes and colleagues, that outcomes in terms of survival are actually very good, almost regardless of therapy in young PBC patients with early disease (although it should be noted that the outcome in terms of survival may be less rosy in older patient groups). 7 Whilst the Combes trial looked at end points including mortality, liver transplantation and clinical parameters, there is no mention of symptomatic and/or QOL assessment.…”

Section: Reflections On Therapeutic Trials In Primary Biliary Cirrhosismentioning

confidence: 99%

Reflections on therapeutic trials in primary biliary cirrhosis: A quality of life oriented counter-view

2006

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Cholestatic Liver Diseases and Health-Related Quality of Life

Abstract: Patients with cholestatic liver disease (PBC and PSC) showed substantial impairment of HRQL, which is further affected by worsening disease severity. Disease-specific measures were better able to discriminate patients with varying severities.

Cited by 142 publications

References 15 publications

Impact of liver transplantation on health-related quality of life

Impact of liver transplantation on health-related quality of life

Effect of molecular adsorbent recirculating system in hepatitis C virus-related intractable pruritus

Reflections on therapeutic trials in primary biliary cirrhosis: A quality of life oriented counter-view

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