Cholestatic hepatitis related to amoxicillin

Chaabane, N. Ben; Safer, L.; Njim, Leïla; Zakhama, Abdelfattah; Saffar, H.

doi:10.3109/01480545.2010.545067

Cited by 4 publications

(2 citation statements)

References 3 publications

(2 reference statements)

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“…In severe reactions, bile duct injury has been reported. The liver injury was mainly related to the clavulanic acid component; as a matter of fact, there are only few reports of hepatic reactions with amoxicillin alone [8][9][10]. Furthermore, the role of clavulanic acid at the onset of liver damage is supported by data on positive rechallenge (second episode of hepatitis) only after re-administration of co-amoxiclav and not after amoxicillin alone [11].…”

Section: Introductionmentioning

confidence: 51%

Liver Injury due to Amoxicillin vs. Amoxicillin/Clavulanate: A Subgroup Analysis of a Drug-Induced Liver Injury Case-Control Study in Italy

Donati¹,

Motola²,

Leone³

et al. 2017

J Hepatol Gastroint Dis

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Objective: Several studies showed that amoxicillin plus clavulanic acid (co-amoxiclav) is one of the most common agents associated to serious Drug Induced Liver Injury (DILI). We estimated the risk of acute serious DILI associated with amoxicillin alone compared with co-amoxiclav, through a multicenter case-control study carried out in nine Italian hospitals from October 2010 to January 2014. Methods:Cases were adults, with a diagnosis of acute liver injury. Controls presented acute clinical disorders, not related to chronic conditions and not involving the liver. Adjusted Odds Ratio (ORs) with 95% CI were calculated initially with a bivariate and then multivariate analysis. Results:We analysed 179 cases matched to 1770 controls. Seven cases were exposed to amoxicillin (adjusted OR 1.69, 95% CI 0.72-3.98) and 22 cases to co-amoxiclav (adjusted OR 3.00, 95% CI 1.76-5.40). Conclusions:Co-amoxiclav almost doubled the risk of serious acute liver injury compared to amoxicillin alone. The incidence of co-amoxiclav induced DILI is very low but the widespread use of this drug by the general population makes the risk clinically relevant. The often inappropriate prescription of antimicrobial agents, and in particular of co-amoxiclav, could expose a given patient to a life-threatening risk compared to a negligible clinical benefit.

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Section: Introductionmentioning

confidence: 51%

Liver Injury due to Amoxicillin vs. Amoxicillin/Clavulanate: A Subgroup Analysis of a Drug-Induced Liver Injury Case-Control Study in Italy

Donati¹,

Motola²,

Leone³

et al. 2017

J Hepatol Gastroint Dis

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“…A recent review details the hepatic damage caused by amoxicillin without clavulanic acid as a hepatocellular pattern [13], whereas there are a few case reports which describe the cholestatic pattern of liver damage by amoxicillin [14,15]. One case report describes the development of a vanishing bile duct syndrome associated with amoxicillin therapy.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Severe Drug-Induced Liver Injury as an Adverse Drug Event of Antibiotics: A Case Report and Review of the Literature

Munz

Grummich²,

Birkmann³

et al. 2017

Chemotherapy

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Drug-induced liver injury is one of the main reasons for acute liver failure. We report the case of a young patient who experienced a drug-induced liver injury resulting in life-threatening acute liver failure after treatment with different antibiotics (amoxicillin, ciprofloxacin, cefazolin, clindamycin) and acetaminophen, or a combination of these drugs. Moreover, we provide an overview of the hepatotoxic potential of these drugs.

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Simultaneous detection of Cu2+ and amoxicillin based on the copper and nitrogen-regulated fluorescent probe

Luo,

Qi,

Jing

et al. 2024

Microchemical Journal

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Cholestatic hepatitis related to amoxicillin

Cited by 4 publications

References 3 publications

Liver Injury due to Amoxicillin vs. Amoxicillin/Clavulanate: A Subgroup Analysis of a Drug-Induced Liver Injury Case-Control Study in Italy

Liver Injury due to Amoxicillin vs. Amoxicillin/Clavulanate: A Subgroup Analysis of a Drug-Induced Liver Injury Case-Control Study in Italy

Severe Drug-Induced Liver Injury as an Adverse Drug Event of Antibiotics: A Case Report and Review of the Literature

Simultaneous detection of Cu2+ and amoxicillin based on the copper and nitrogen-regulated fluorescent probe

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