The older concepts of amyloidosis are gradually losing their validity. During the last decade and a half, the knowledge of the chemical nature, pathogenesis, classification, clinical features and diagnostic measures has expanded enormously. Application of current diagnostic means – both clinical and pathological – will enable the physicians to diagnose amyloidosis early, and correctly, and to recognize the associated conditions. Correct and timely diagnosis should help institute appropriate therapy. This review is an effort to briefly describe – for diagnostic purposes – clinical, chemical, and (immuno-) pathological aspects of amyloidosis.