Cholesta-3:5-dien-7-one in human atherosclerotic aortas

Kantiengar, N. L.; Morton, R. A.

doi:10.1042/bj0600025

Cited by 27 publications

(4 citation statements)

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“…This result cannot, however, be safely given general application, because wool fat may well have been oxidized by air as far as the dienone precursor (7-oxocholesteryl ester) before saponification. Such oxidation need not occur in all lipid material; thus it is significant that brain tissue which is very rich in cholesterol did not produce the dienone even after saponification in hot ethanolic potash and working up in the ordinary way (Kantiengar & Morton, 1955). For the present it must be concluded that although the cholesta-3:5-dien-7-one may be an artifact, it is not safe to assume that it is necessarily so.…”

Section: Discussionmentioning

confidence: 72%

Some minor constituents of liver oils

Cain

Morton

1955

Biochemical Journal

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Section: Discussionmentioning

confidence: 72%

Some minor constituents of liver oils

Cain

Morton

1955

Biochemical Journal

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“…The presence of the dienone cholesta-3:5-dien-7-one in atheromatous arteries has been reported by Hardegger, Ruzicka & Tagmann (1943) and by Kantiengar & Morton (1955).…”

Section: R-mentioning

confidence: 82%

The use of polarography in the examination of ketosteroids related to cholesterol

Robertson

1955

Biochemical Journal

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“…The results of studies in humans have pointed to the presence of low levels of oxysterols in human atherosclerotic lesions. These include 26-OH-Chol, 7-keto-Chol, 7␣-OH-Chol, 7␤-OH-Chol, 25-OH-Chol, 4␤-OH-Chol, 4␣-OH-Chol, 5␣,6␤-diOH-Chol, and cholesta-3,5-dien-7-one (66,84,130,133,135,160,161,319,476,1011,1157). The latter is a known product of the decomposition of 7-keto-Chol.…”

Section: Appeared Very Recently]mentioning

confidence: 99%

Oxysterols: Modulators of Cholesterol Metabolism and Other Processes

Schroepfer

2000

Physiological Reviews

873

687

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Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of biological activities, including effects on sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation. The most notable oxysterol activities center around the regulation of cholesterol homeostasis, which appears to be controlled in part by a complex series of interactions of oxysterol ligands with various receptors, such as the oxysterol binding protein, the cellular nucleic acid binding protein, the sterol regulatory element binding protein, the LXR nuclear orphan receptors, and the low-density lipoprotein receptor. Identification of the endogenous oxysterol ligands and elucidation of their enzymatic origins are topics of active investigation. Except for 24, 25-epoxysterols, most oxysterols arise from cholesterol by autoxidation or by specific microsomal or mitochondrial oxidations, usually involving cytochrome P-450 species. Oxysterols are variously metabolized to esters, bile acids, steroid hormones, cholesterol, or other sterols through pathways that may differ according to the type of cell and mode of experimentation (in vitro, in vivo, cell culture). Reliable measurements of oxysterol levels and activities are hampered by low physiological concentrations (approximately 0.01-0.1 microM plasma) relative to cholesterol (approximately 5,000 microM) and by the susceptibility of cholesterol to autoxidation, which produces artifactual oxysterols that may also have potent activities. Reports describing the occurrence and levels of oxysterols in plasma, low-density lipoproteins, various tissues, and food products include many unrealistic data resulting from inattention to autoxidation and to limitations of the analytical methodology. Because of the widespread lack of appreciation for the technical difficulties involved in oxysterol research, a rigorous evaluation of the chromatographic and spectroscopic methods used in the isolation, characterization, and quantitation of oxysterols has been included. This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.

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Cholesta-3:5-dien-7-one in human atherosclerotic aortas

Cited by 27 publications

References 4 publications

Some minor constituents of liver oils

Some minor constituents of liver oils

The use of polarography in the examination of ketosteroids related to cholesterol

Oxysterols: Modulators of Cholesterol Metabolism and Other Processes

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