Choleretic activity of Gentiana lutea ssp. symphyandra in rats

Oztürk, Nilgiin; Herekman-Demir, T.; Öztürk, Yusuf; Bozan, Berrin; Başer, K. Hüsnü Can

doi:10.1016/s0944-7113(98)80067-6

Cited by 25 publications

(15 citation statements)

References 9 publications

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“…The roots and rhizomes of G. lutea showed hepatoprotective [30], antioxidant [31], and anti-inflammatory activity [32] and are used as an appetite stimulant [33]. The medicinal value is due to presence of secoiridoid glycosides and xanthones located mostly in the cortex of the roots of plants belonging to the family of Gentianaceae such as Gentianella and Gentiana [34].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Aldose Reductase byGentiana luteaExtracts

Akileshwari

Muthenna

Nastasijević

et al. 2012

Experimental Diabetes Research

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Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes. Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications. Gentiana lutea grows naturally in the central and southern areas of Europe. Its roots are commonly consumed as a beverage in some European countries and are also known to have medicinal properties. The water, ethanol, methanol, and ether extracts of the roots of G. lutea were subjected to in vitro bioassay to evaluate their inhibitory activity on the ALR2. While the ether and methanol extracts showed greater inhibitory activities against both rat lens and human ALR2, the water and ethanol extracts showed moderate inhibitory activities. Moreover, the ether and methanol extracts of G. lutea roots significantly and dose-dependently inhibited sorbitol accumulation in human erythrocytes under high glucose conditions. Molecular docking studies with the constituents commonly present in the roots of G. lutea indicate that a secoiridoid glycoside, amarogentin, may be a potential inhibitor of ALR2. This is the first paper that shows G. lutea extracts exhibit inhibitory activity towards ALR2 and these results suggest that Gentiana or its constituents might be useful to prevent or treat diabetic complications.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Aldose Reductase byGentiana luteaExtracts

Akileshwari

Muthenna

Nastasijević

et al. 2012

Experimental Diabetes Research

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“…Eur. Some studies showed that the root possesses cholagogue, anthelmintic, anti-inflammatory, and antimicrobial activity (Öztütk et al 1998;Pontus et al 2006;Šavikin et al 2007). The material is stabilized (unfermented), yellow colored, and very bitter.…”

Section: Gentiana Lutea L (Yellow Gentian)mentioning

confidence: 99%

The Gentianaceae - Volume 2: Biotechnology and Applications

Rybczyński¹,

Davey²,

Mikuła³

2015

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“…L'administration intraduodénale de 500 mg/kg de poids corporel d'un extrait éthanolique à 95 %, obtenu des racines et des rhizomes, présente des effets cholérétiques chez le rat [28].…”

Section: Activité Cholérétiqueunclassified

“…Une perfusion intrastomacale à 4 %, chez le rat, d'un extrait éthanolique (éthanol à 30 %) issu des racines et des rhizomes de gentiane, augmente de 37 % la sécrétion gastrique [28].…”

Section: Activité Sécrétoireunclassified