Cholemic Nephropathy Reloaded

Fickert, Peter; Rosenkranz, Alexander R.

doi:10.1055/s-0039-1698826

Cited by 23 publications

(16 citation statements)

References 63 publications

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“…The most studied is neutrophil gelatinase-associated lipocalin (NGAL), a 25 kDa iron-transporting protein excreted in nephrotoxic or ischemic kidney injury. Urinary(u) NGAL levels in CN were shown to be suitable to monitor tubular epithelial damage and therapeutic effects under experimental conditions [ 1 , 45 ]. The diagnostic odds ratio (DOR) and sample size-weighted area under the curve for the receiver-operating characteristic (AUC-ROC) for NGAL to predict AKI were 18.6 (95% CI: 9.0-38.1)/0.815 (95% CI: 0.732-0.892) in a meta-analysis study of 19 studies with AKI [ 46 ].…”

Section: Reviewmentioning

confidence: 99%

Bile Cast Nephropathy: A Comprehensive Review

Somagutta¹,

Jain²,

Pormento³

et al. 2022

Cureus

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Section: Reviewmentioning

confidence: 99%

Bile Cast Nephropathy: A Comprehensive Review

Somagutta¹,

Jain²,

Pormento³

et al. 2022

Cureus

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“…The tubular injury characterizes it in the distal nephron segments secondary to the intratubular cast formation which causes obstruction and dilatation of the tubules. [81][82][83][84][85][86][87][88][89] In a large retrospective cohort study of postmortem kidney biopsies of 127 patients, bile cast nephropathy or cholemic nephrosis was observed in 72.1% of patients with ACLF versus 27.4% of patients with decompensated cirrhosis. The presence of high serum bilirubin and ACLF was significant predictors of cholemic nephrosis.…”

Section: Cholemic Organ Dysfunctionmentioning

confidence: 99%

Plasma Exchange in Acute and Acute on Chronic Liver Failure

Maiwall

Sarin

2021

Semin Liver Dis

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Liver failure in the context of acute (ALF) and acute on chronic liver failure (ACLF) is associated with high mortality in the absence of a liver transplant. For decades, therapeutic plasma exchange (TPE) is performed for the management of immune-mediated diseases. TPE has emerged as an attractive extracorporeal blood purification technique in patients with ALF and ACLF. The basic premise of using TPE is to remove the toxic substances which would allow recovery of native liver functions by facilitating liver regeneration. In recent years, encouraging data have emerged, suggesting the benefits of TPE in patients with liver failure. TPE has emerged as an attractive liver support device for the failing liver until liver transplantation or clinical recovery. The data in patients with ALF suggest routine use of high-volume TPE, while the data for such a strategy are less robust for patients with ACLF.

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“…Hydrophobic bile acids are the most suspicious compounds in the pathogenesis of cholestasis-induced renal injury [ 4 , 5 , 8 , 9 ]. It has been well documented that hydrophobic bile acids can disrupt the function of different cellular targets, including biomembrane lipids, various proteins, as well as vital organelles such as mitochondria [ 8 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline mitigates cholestasis-related cholemic nephropathy

Ommati¹,

Hojatnezhad²,

Abdoli³

et al. 2021

ceh

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Aim of the study Cholestasis is the stoppage of bile flow that primarily affects liver function. On the other hand, kidneys are also severely influenced during cholestasis. Cholestasis-induced kidney injury is known as cholemic nephropathy (CN). There is no precise pharmacological option in CN. Previous studies revealed that oxidative stress plays a crucial role in the pathogenesis of CN. On the other hand, the positive effects of pentoxifylline (PTX) against renal injury with different etiologies have been frequently reported. In the current study, the potential nephroprotective role of PTX in cholestasis-induced renal injury is investigated. Material and methods Bile duct ligated (BDL) rats were treated with PTX (10, 50, and 100 mg/kg), and renal markers of oxidative stress, urine level of inflammatory cytokines, as well as renal histopathological alterations were monitored. Results Significant changes in oxidative stress markers were detected in the BDL group. On the other hand, it was found that PTX (10, 50, and 100 mg/kg) significantly ameliorated cholestasis-induced oxidative stress in renal tissue. Renal histopathological changes, including interstitial inflammation, tubular atrophy, fibrosis, and cast formation, were detected in the BDL rats. Moreover, urine pro-inflammatory cytokines [interleukin (IL)-1, IL-9, IL-18, tumor necrosis factor α (TNF-α), and interferon γ (INF-γ)] were significantly increased in the cholestatic animals. PTX (10, 50, and 100 mg/kg, 14 days) significantly ameliorated renal histopathological alterations and urine levels of inflammatory cytokines. Conclusions These data indicate a potential nephroprotective role for PTX in cholestasis. The effects of PTX on oxidative stress parameters and the inflammatory response could play a primary role in its renoprotective mechanisms.

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Cholemic Nephropathy Reloaded

Cited by 23 publications

References 63 publications

Bile Cast Nephropathy: A Comprehensive Review

Bile Cast Nephropathy: A Comprehensive Review

Plasma Exchange in Acute and Acute on Chronic Liver Failure

Pentoxifylline mitigates cholestasis-related cholemic nephropathy

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