Cholelithiasis in newborns and infants

St-Vil, Dickens; Yazbeck, Salam; Luks, François I.; Hancock, B.J.; Filiatrault, D; Youssef, Sami

doi:10.1016/0022-3468(92)90281-b

Cited by 65 publications

(63 citation statements)

References 19 publications

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“…Considering the absence of risk factors and symptoms, the high frequency in the fi rst year of life and the fact that some cases had spontaneous resolution of the biliary sludge or gallstones, these results are in agreement with the medical literature. 5,7,20,21 It has been reported 9 that biliary sludge can be a precursor for biliary lithiasis, but this was not observed in our study.…”

Section: Resultscontrasting

confidence: 68%

“…However, the majority of cases of biliary abnormalities in children, particularly during the neonatal period, are non-symptomatic and idiopathic, with predominance among males and spontaneous resolution within six months after the ultrasound diagnosis in most cases. 9,11,21 Despite the existence of studies demonstrating increased frequency of cholelithiasis among neonates and children who present associations with particular risk factors, 4-6 few of them describe associations with DS. 7,12,13,15 In the general pediatric population, cholelithiasis prevalence has been found to be 0.13% to 0.22%.…”

Section: Resultsmentioning

confidence: 99%

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Cholelithiasis and biliary sludge in Down’s syndrome patients

et al. 2007

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CONTEXT AND OBJECTIVE: Although studies have demonstrated increased frequency of gallbladder abnormalities among Down’s syndrome (DS) patients in some countries, there is only one paper on this subject in the Brazilian literature. The aim of this study was to demonstrate the prevalence, clinical characteristics and evolution of lithiasis and biliary sludge among DS patients in a maternity and children’s hospital in Rio de Janeiro. DESIGN AND SETTING: This was a cross-sectional study followed by a retrospective cohort study on all individuals with an ultrasound diagnosis of gallbladder abnormalities. METHODS: 547 DS patients (53.2% male, 46.8% female) attending the Instituto Fernandes Figueira in 2001 underwent abdominal ultrasound examination at ages of between one day and three years (mean: five months). Clinical and ultrasound data were analyzed. RESULTS: In 50 patients (9.1%), the ultrasound demonstrated gallbladder abnormalities (6.9% lithiasis and 2.1% biliary sludge). Spontaneous resolution was observed in 66.7% of the patients with biliary sludge and 28.9% with lithiasis. Cholecystectomy was carried out on 26.3% of the patients with gallstones. CONCLUSION: The results from this study and comparison with the literature suggest that DS patients are at risk of developing lithiasis and biliary sludge and should be monitored throughout the neonatal period, even if there are no known risk factors for gallstone formation. Most frequently, these gallbladder abnormalities occur without symptoms and spontaneously resolve in most non-symptomatic patients. DS patients should be monitored with serial abdominal ultrasound, and cholecystectomy is indicated for symptomatic cases or when cholecystitis is present.

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Section: Resultscontrasting

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Cholelithiasis and biliary sludge in Down’s syndrome patients

et al. 2007

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“…La cirugía en niños con cálculos de colesterol está indicada en niños con recurrencia de crisis de dolor. Se ha discutido la indicación quirúrgi-ca en pacientes asintomáticos dado el riesgo teórico de cáncer vesicular, considerando el riesgo familiar de cáncer vesicular 24 , la relación inversa entre colecistectomía y cáncer vesicular 25 y asociación entre colelitiasis y cán-cer vesicular 26,27 . Una situación especial es la indicación en menores de 1 año, en los que se debe tomar la precaución de un período de observación mayor a 1 año, considerando el mayor porcentaje de resolución espontánea en este grupo etario 28 .…”

Section: Cálculos De Colesterolunclassified

Litiasis biliar pediátrica en una población de alta prevalencia

Chateau

2007

Rev. chil. pediatr.

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Childhood Cholelithiasis in a high prevalent populationBile duct disease and gallstone (cholelithiasis) have been considered an uncommon cause of acute abdominal pain in children compared to adults. However, there are significant differences with the adult gallstone disease: increased proportion of patients with an underlying condition, higher incidence of acalculous cholecystitis and lower frequency of choledocolithiasis. With ultrasound examination, it is possible to detect early gallstone in the fetal period and in asymptomatic patients, explaining the increase in gallstone incidence. This disease is more common than suggested in western literature and its diagnosis is increasing as well. The high prevalence of gallstone in adult population in Chile creates an ideal setting for cholesterol and gallstone candidate gene testing. Although the clinical diagnosis of gallstone is simple, there is no consensus about the best therapy in children, explained partially by the lack of knowledge of the natural history of the disease. The role of gallstone disease acquired early in life in gallbladder carcinoma deserves special attention. RESUMENLas enfermedades de la vía biliar y los cálculos vesiculares (colelitiasis) han sido consideradas como una causa poco frecuentes de dolor abdominal agudo en niños, a diferencia de lo que ocurre en adultos. Sin embargo, existen diferencias sustanciales con el adulto como son una mayor proporción de casos con causa identificable, mayor incidencia de colecistitis sin cálculos y menor frecuencia de coledocolitiasis. Con la masificación del ultrasonido es posible detectar litiasis biliar en etapa intrauterina, y en pacientes asintomáticos, lo que estaría explicando, en parte, el aumento de su incidencia. La litiasis biliar es más frecuente de lo sugerido clásicamente en la literatura occidental y su diagnóstico está en aumento. La alta prevalencia de colelitiasis en población adulta chilena, posicionan a nuestro país como un escenario ideal para el estudio de genes candidatos asociados a la etiopatogénesis de la litiasis de colesterol. Si bien el diagnóstico de la litiasis es relativamente simple, no hay consenso en la terapia de elección, lo que se explica fundamentalmente por una historia natural desconocida. El rol de la litiasis de colesterol a edades tempranas en la etiopatogénesis de procesos neoplásicos de la vía biliar merece especial atención.

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“…A ocorrência de colelitíase no período neonatal e no lactente jovem vem sendo descrita com mais freqüência em razão do aumento do uso do ultrasom abdominal 4,5 . Na infância, a colelitíase está geralmente associada à doença hemolítica 6 .…”

Section: Introductionunclassified

“…Na infância, a colelitíase está geralmente associada à doença hemolítica 6 . Entretanto, no período neonatal, os seguintes fatores de risco têm sido relacionados: prematuturidade, sepsis, nutrição parenteral total, uso prolongado de Furosemida, hemólise e mal-formações de vias biliares 1,4,7,8 . A colelitíase neonatal pode caracterizarse pelo seu diagnóstico acidental e possível resolução espontânea [8][9][10][11] .…”

Section: Introductionunclassified

Asymptomatic cholelithiasis in an extreme premature child

Cunha¹,

Barros²

2000

J Pediatr (Rio J)

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Cholelithiasis in newborns and infants

Cited by 65 publications

References 19 publications

Cholelithiasis and biliary sludge in Down’s syndrome patients

Cholelithiasis and biliary sludge in Down’s syndrome patients

Litiasis biliar pediátrica en una población de alta prevalencia

Asymptomatic cholelithiasis in an extreme premature child

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