Cholelithiasis in gallbladder cancer: Coincidence, cofactor, or cause!

Shrikhande, Shailesh V.; Barreto, Savio George; Singh, Sapna; Udwadia, Tehemton E.; Agarwal, Anil

doi:10.1016/j.ejso.2010.05.002

Cited by 96 publications

(60 citation statements)

References 56 publications

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“…1,2 More recently, clinically diagnosed gallstone disease, including symptomatic gallstones or cholecystectomy, has been explored in cohort studies and associated with higher overall occurrence of cancer, 3,4 with gastrointestinal cancers such as hepatic, 5 biliary, [6][7][8] pancreatic, 4,9 esophageal, 10,11 gastric, 8,12 small intestines, 4,13,14 colon, 4,8,[13][14][15][16][17][18][19] and with nongastrointestinal cancers, such as breast 4,20 and prostate. 21 However, these studies may be biased by the increased risk of cancer detection after clinically diagnosed gallstone disease.…”

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confidence: 99%

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

2017

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confidence: 99%

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

2017

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“…Thus, in conclusion, we concur with Dr. Kai that every effort must be made to completely understand gallbladder carcinogenesis taking into account every known precursor lesion (18,19). Knowledge gained through such an exercise will only help us develop better and more effective treatment strategies for gallbladder cancer.…”

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confidence: 57%

To improve outcomes of gallbladder cancer we need to better understand it!

Barreto

Dutt

2016

Hepatobiliary Surg. Nutr.

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“…It is thus difficult at the present time to firmly conclude whether gallstones are the cause of GBC. Thay may however be regarded as cofactors [26]. The best therapeutic treatment of GBC is curative resection which, unfortunately, by the time of diagnosis is possible in only 15-30% of the tumors.…”

Section: Discussionmentioning

confidence: 99%

Cholecystoduodenocolic Fistula by Gallbladder Carcinoma that Presenting as Bouveret's Syndrome: Case Report and Review of the Literature

Cianci¹,

Ambrosi²,

Fersini³

et al. 2014

Int J Gastroenterol Disord Ther

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We describe the first case in the literature of Bouveret's syndrome as the result of a cholecystoduodenocolic fistula secondary to gallbladder carcinoma. A 67-years-old woman was admitted to our department presenting with complaints of severe cramping abdominal pain, localized predominantly in the right hypochondrium and epigastrium, with infrequent alimentary and biliary vomiting for about three months. Based on the radiological and endoscopic findings, the provisional diagnosis of Bouveret's syndrome in a patient with cholecystoduodenal fistula and history of cholelithiasis was made. The laparotomy showed the presence of the stone in the duodenal bulb, already seen at endoscopy, and adhesions between gallbladder, superior duodenal flexure and hepatic flexure of the colon, and this inflammatory gangue strethed up to the hepatic hilum. During dissection in addition to the communication between the gallbladder and the duodenum, another fistula was found that led from the gallbladder to the colon. The suspicion of malignancy of this multiple biliary enteric fistula was confirmed by intraoperative frozen sections that revealed the precence of a poorly differentiated carcinoma of biliary-pancreatic origin, but the ultimate diagnosis of gallbladder carcinoma was made exclusively after the definitive histopathological examination. For these reasons the surgical procedure involved cholecystectomy with resection of the regional lymph nodes, gastrotomy with extraction of gallstone, trans-mesocolic Roux-en-Y gastro-jejunal mechanical anastomosis, resection of the hepatic flexure of the colon with termino-lateral colo-colic mechanical anastomosis. It's important to remember that rarely the Bouveret's syndrome can hide multiple biliary enteric fistulas or even a malignancy. We believe, in the light of our experience, that the surgical approach represents the first choice in the treatment of this serious disease.

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Cholelithiasis in gallbladder cancer: Coincidence, cofactor, or cause!

Cited by 96 publications

References 56 publications

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

To improve outcomes of gallbladder cancer we need to better understand it!

Cholecystoduodenocolic Fistula by Gallbladder Carcinoma that Presenting as Bouveret's Syndrome: Case Report and Review of the Literature

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