Cholelithiasis – a particular threat to women. A review of risk factors

Lazarchuk, Ivanna; Barzak, Bartosz; Wozniak, Slawomir; Mielczarek, Anna; Lazarchuk, Vitalii

doi:10.2478/acb-2023-0003

Cited by 3 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cross-sectional design, while effective for determining prevalence, does not allow for conclusions about causality between diabetes and gallstone disease. Additionally, the study was confined to a single geographic area, which might limit the generalizability of the findings to other populations (17)(18)(19). Further research is recommended to explore the causal relationships in a longitudinal framework, which could provide insights into the progression of gallstone disease over time in diabetic versus non-diabetic individuals.…”

Section: Discussionmentioning

confidence: 99%

“…The study's implications for clinical practice are significant, suggesting that diabetic patients, particularly those experiencing right hypochondriac pain, should be considered for routine gallstone screening. This could potentially lead to earlier detection and management of gallstone disease, thereby improving patient outcomes and reducing the healthcare burden associated with complications of untreated gallstones (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sonographic Evaluation of Cholelithiasis in Diabetic Patients at District Swabi

Rangeen,

Ulain,

Amna Shehzadi

et al. 2024

JHRR

View full text Add to dashboard Cite

Background: Cholelithiasis, the formation of gallstones in the gallbladder, is prevalent among individuals experiencing abdominal discomfort such as epigastric pain, nausea, and loss of appetite. The relationship between diabetes and the increased risk of developing gallstones has been noted, highlighting the importance of understanding this association for better disease management. Objective: The aim of this study was to evaluate the prevalence and characteristics of gallstones in diabetic patients in the district of Swabi using ultrasonography to enhance early diagnosis and treatment approaches. Methods: This cross-sectional study was conducted at the Department of Radiology, District Head Quarters Hospital, Swabi, Pakistan. Participants included individuals presenting with upper right quadrant pain or with a history of diabetes. Ultrasonographic examinations were performed using a Toshiba Xeiro convex probe with a frequency range of 3-5 MHz. Data was collected through clinical histories and radiographic examinations, and analyzed using SPSS version 25. Ethics approval was obtained in accordance with the Declaration of Helsinki, and all participants provided informed consent. Results: A total of 112 patients were enrolled with ages ranging from 8 to 80 years (mean ± SD = 39.37 ± 16.72 years). Females constituted 56.4% (n=62) and males 43.6% (n=48) of the study population. The majority, 88.2% (n=97), reported right hypochondriac pain. Among the patients, 60% (n=66) had multiple gallstones; of these, 36.4% (n=24) were diabetic. Conversely, 40% (n=44) had a single stone, with 38.6% (n=17) being diabetic. Conclusion: The study indicates a significant association between diabetes and the presence of multiple gallstones, underscoring the need for routine ultrasonographic screening in diabetic patients experiencing right hypochondriac pain. Early detection could lead to better management and potentially reduce complications associated with cholelithiasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sonographic Evaluation of Cholelithiasis in Diabetic Patients at District Swabi

Rangeen,

Ulain,

Amna Shehzadi

et al. 2024

JHRR

View full text Add to dashboard Cite

show abstract

“…With this said, a 6-month post-operative period is not adequate to assess morbidity. The patient is a female of reproductive age (40 years old) who is at risk for further gallstone formation [ 4 ].…”

mentioning

confidence: 99%

Letter to the editor RE: “Gallstone ileus - A rare presentation in the era of rampant cholecystectomies”

Callender

2024

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

Cholelithiasis, Gut Microbiota and Bile Acids after Bariatric Surgery—Can Cholelithiasis Be Prevented by Modulating the Microbiota? A Literature Review

Komorniak,

Pawlus,

Gaweł

et al. 2024

Nutrients

View full text Add to dashboard Cite

Background: Cholelithiasis is one of the more common complications following bariatric surgery. This may be related to the rapid weight loss during this period, although the exact mechanism of gallstone formation after bariatric surgery has not been fully elucidated. Methods: The present literature review focuses on risk factors, prevention options and the impact of the gut microbiota on the development of gallbladder stones after bariatric surgery. Results: A potential risk factor for the development of cholelithiasis after bariatric surgery may be changes in the composition of the intestinal microbiota and bile acids. One of the bile acids—ursodeoxycholic acid—is considered to reduce the concentration of mucin proteins and thus contribute to reducing the formation of cholesterol crystals in patients with cholelithiasis. Additionally, it reduces the risk of both asymptomatic and symptomatic gallstones after bariatric surgery. Patients who developed gallstones after bariatric surgery had a higher abundance of Ruminococcus gnavus and those who did not develop cholelithiasis had a higher abundance of Lactobacillaceae and Enterobacteriaceae. Conclusion: The exact mechanism of gallstone formation after bariatric surgery has not yet been clarified. Research suggests that the intestinal microbiota and bile acids may have an important role in this.

show abstract

Cholelithiasis – a particular threat to women. A review of risk factors

Cited by 3 publications

References 35 publications

Sonographic Evaluation of Cholelithiasis in Diabetic Patients at District Swabi

Sonographic Evaluation of Cholelithiasis in Diabetic Patients at District Swabi

Letter to the editor RE: “Gallstone ileus - A rare presentation in the era of rampant cholecystectomies”

Cholelithiasis, Gut Microbiota and Bile Acids after Bariatric Surgery—Can Cholelithiasis Be Prevented by Modulating the Microbiota? A Literature Review

Contact Info

Product

Resources

About