Choledochal cyst type IA with drainage through the ventral duct in pancreas divisum

Bechtler, Matthias; Eickhoff, A.; Willis, Sean; Riemann, J. F.

doi:10.1055/s-0028-1119485

Cited by 6 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 However, data on the incidence and role in biliary carcinogenesis of PBMs that are unaccompanied by choledochal cysts (''nondilated'' type) are highly limited in the Western hemisphere. It has been increasingly appreciated that the frequency of PBM in the US population may in fact be similar to that in Japan, [17][18][19][20][21] about 1% of the population.…”

mentioning

confidence: 99%

Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis

et al. 2020

View full text Add to dashboard Cite

Objective:To determine the associations of pancreatobiliary maljunction (PBM) in the West.Background:PBM (anomalous union of common bile duct and pancreatic duct) is mostly regarded as an Asian-only disorder, with 200X risk of gallbladder cancer (GBc), attributed to reflux of pancreatic enzymes. Methods: Radiologic images of 840 patients in the US who underwent pancreatobiliary resections were reviewed for PBM and contrasted with 171 GBC cases from Japan.Results:Eight % of the US GBCs (24/300) had PBM (similar to Japan; 15/ 171, 8.8%), in addition to 1/42 bile duct carcinomas and 5/33 choledochal cysts. None of the 30 PBM cases from the US had been diagnosed as PBM in the original work-up. PBM was not found in other pancreatobiliary disorders. Clinicopathologic features of the 39 PBM-associated GBCs (US:24, Japan:15) were similar; however, comparison with non-PBM GBCs revealed that they occurred predominantly in females (F/M = 3); at younger (<50-year-old) age (21% vs 6.5% in non-PBM GBCs; P = 0.01); were uncommonly associated with gallstones (14% vs 58%; P < 0.001); had higher rate of tumor-infiltrating lymphocytes (69% vs 44%; P = 0.04); arose more often through adenoma-carcinoma sequence (31% vs 12%; P = 0.02); and had a higher proportion of nonconventional carcinomas (21% vs 7%; P = 0.03). Conclusions: PBM accounts for 8% of GBCs also in the West but is typically undiagnosed. PBM-GBCs tend to manifest in younger age and often through adenoma-carcinoma sequence, leading to unusual carcinoma types. If PBM is encountered, cholecystectomy and surveillance of bile ducts is warranted. PBM-associated GBCs offer an invaluable model for variant anatomy-induced chemical (reflux-related) carcinogenesis.

show abstract

mentioning

confidence: 99%

Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Choledochal cyst association with pancreas divisum in adults is a rare condition, and in our knowledge less than 8 well-documented cases have been reported 256789. In this patient, the choledochal cysts was categorized as type I according to the Todani et al classification, due to the cyst localization on the extrahepatic biliary tree (Table 1).…”

Section: Discussionmentioning

confidence: 81%

A rare case of choledochal cyst with pancreas divisum: case presentation and literature review

Ransom-Rodríguez

Blachman‐Braun

Ramos

et al. 2017

Ann Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

Choledochal cysts are rare congenital malformations of the bile duct characterized by dilatations of the intrahepatic and/or extrahepatic portion of the biliary tree, they are associated to an anomalous arrangement of the pancreaticobiliary duct. Pancreas divisum results from a fusion failure of the pancreatic buds. The coexistence of pancreas divisum and choledochal cyst in adults has been reported in less than 10 well documented cases. This article presents a case of a 42-year-old Peruvian man with intermittent episodes of abdominal pain, initially diagnosed with choledocholithiasis, who underwent open cholecystectomy. During surgery, a diagnosis of choledochal cyst and pancreas divisum was made, and therefore a hepaticoduodenostomy was performed. The patient was referred to our hospital due to persistence of abdominal pain. After admission, a papillectomy was achieved without further complications. A cyst resection and dismantling of hepaticoduodenostomy with Roux-en-Y was performed 8 years later. During the subsequent 18-month follow-up, the patient remains asymptomatic.

show abstract

Pancreaticobiliary maljunction (PBM) complicated with complete pancreas divisum

Tomonaga

Tahara

Kutsukake

et al. 2019

Journal of Pediatric Surgery Case Reports

View full text Add to dashboard Cite

Choledochal cyst type IA with drainage through the ventral duct in pancreas divisum

Cited by 6 publications

References 3 publications

Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis

Pancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis

A rare case of choledochal cyst with pancreas divisum: case presentation and literature review

Pancreaticobiliary maljunction (PBM) complicated with complete pancreas divisum

Contact Info

Product

Resources

About