Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Abstract

Cholecystokinin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on CCK receptors [89]) are activated by the endogenous peptides cholecystokinin-8 ( CCK-8), . There are only two distinct subtypes of CCK receptors, CCK 1 and CCK 2 receptors [63,123], with some alternatively spliced forms most often identified in neoplastic cells. The CCK receptor subtypes are distinguished by their peptide selectivity, with the CCK 1 receptor requiring the carboxyl-terminal heptapeptideamide that includes a sulfated tyrosine for high affinity and potency, while the CCK 2 receptor requires only the carboxyl-terminal tetrapeptide shared by each CCK and gastrin peptides. These receptors have characteristic and distinct distributions, with both present in both the central nervous system and peripheral tissues. ContentsThis is a citation summary for Cholecystokinin receptors in the Guide to Pharmacology database (GtoPdb). It exists purely as an adjunct to the database to facilitate the recognition of citations to and from the database by citation analyzers. Readers will almost certainly want to visit the relevant sections of the database which are given here under database links.GtoPdb is an expert-driven guide to pharmacological targets and the substances that act on them. GtoPdb is a reference work which is most usefully represented as an on-line database. As in any publication this work should be appropriately cited, and the papers it cites should also be recognized. This document provides a citation for the relevant parts of the database, and also provides a reference list for the research cited by those parts.Please note that the database version for the citations given in GtoPdb are to the most recent preceding version in which the family or its subfamilies and targets were substantially changed. The links below are to the current version. If you need to consult the cited version, rather than the most recent version, please contact the GtoPdb curators.

Peptidergic modulation of fear responses by the Edinger-Westphal nucleus

“…Taken together, our results suggest that the CART + EW excites subpopulations of neurons in the BSTov and dStr and that the CART + EW excitation of striatal projection neurons is dependent on intracellular Gαs-signaling cascades. The importance of Gαs-intracellular cascades for CART + EW signaling aligns with the presence of numerous Gαs-linked peptides in the CART + EW, including urocortin, PACAP, and CCK (Beinfeld et al, 2019;Dautzenberg et al, 2019;Fahrenkrug et al, 2019). Furthermore, we see no evidence that the CART + EW is functionally glutamatergic.…”

Investigation of Cholecystokinin-Beta receptor, IL-27, IL-27 gene SNP and some biochemical parameters in patients with Type-1 Diabetes Mellitus

“…In the stomach (parietal, chief, and ECL cells of the gastric mucus), human pancreas, and specific parts of the central and peripheral neurological systems, CCK2R/GR are detected, whereas CCK1R/GR are present (CNS). Cholecystokinin receptors CCK and gastrin bind to CCK receptors, G protein-coupled receptors that bind the peptide hormones CCK and gastrin 17 . The CCKA and CCKB subtypes are 50% identical; there are two types of CCKR; the first is CCK-A receptors.…”