Cholecystokinin octapeptide stimulates phasic and tonic pyloric motility in healthy humans.

Fraser, Robert; Fone, David R.; Horowitz, Michael; Dent, John

doi:10.1136/gut.34.1.33

Cited by 64 publications

(54 citation statements)

References 19 publications

(6 reference statements)

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“…The widely described stimulatory action of CCK on gallbladder contraction was firstly recognized as the ability of the hormone to affect tonic contractions (Walsh 1994). However, some other reports indicate that CCK can stimulate tonic motility in the stomach, pylorus and ruminal muscle (Fraser et al 1993;Lüdtke et al 1988;Onaga et al 1989) as well as in the large intestine (Coffin et al 1999) in various animal species including ruminants. Other reports suggest that CCK and related peptides increase tonic contractions in the small bowel of monogastrics (Dollinger et al 1975;Niederau and Karaus 1991;Stacher et al 1984;Stewart and Burks 1977) but other authors did not make this observation (Anuras and Cooke 1978;Gutiérez et al 1974).…”

Section: Discussionmentioning

confidence: 96%

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Romanski¹

2007

Acta Vet. Brno

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Cholecystokinin (CCK) can affect phasic contractions and the minute rhythm (MR) in ovine duodenum but its effect on the tonic component remains unclear. Thus, the aim of this study was to assess whether the hormone exerts significant changes on phasic and tonic components of the duodenal motor activity and on phasic and tonic components of the duodenal MR. Mechanical and electrical activities of the duodenum were recorded in four sheep before and after slow intravenous cholecystokinin octapeptide (CCK-OP, doses 20, 200 and 2000 ng/kg b.w.) and cerulein (doses 1, 10 and 100 ng/kg b.w.) administration in the course of phase 2b of the migrating motor complex. During 5-20-minute periods the area under contraction curve for phasic, tonic and total motor activity was measured for the whole curve and separately for the MR-related activity. It was found that both CCK peptides stimulate phasic and tonic components of the duodenal motor activity as well as both these components of the duodenal MR. The effect of CCK peptides on the tonic component was stronger than on the phasic component. These effects were similar in non-fasted and fasted animals. CCK-OP evoked slightly greater effect than cerulein. The effects of these CCK peptides on phasic and tonic components of the MR were similar. It is concluded that CCK-OP and cerulein stimulate both phasic and tonic components of the duodenal motor activity and phasic and tonic components related to the MR in sheep. , small bowel, myoelectrical and motor activity, cholecystokinin Ruminants

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Section: Discussionmentioning

confidence: 96%

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Romanski¹

2007

Acta Vet. Brno

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“…Other factors that might be considered as causative for this complication are disruption of gastroduodenal neural connections 28,29 and ischemia of the pyloric muscle. 30 Ligation of the right gastric artery is generally performed because it facilitates resection of the gastroduodenal artery, but some authors have advocated preserving the right gastric artery because of its arterial supply to the pylorus and antrum. 31 In the present series, the right gastric artery was always ligated.…”

Section: Discussionmentioning

confidence: 99%

Delayed Gastric Emptying After Standard Pancreaticoduodenectomy Versus Pylorus-Preserving Pancreaticoduodenectomy: An analysis of 200 Consecutive Patients

Henegouwen¹

1997

Journal of the American College of Surgeons

179

113

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“…Furthermore, certain properties of ingested food, such as volume, osmolality, pH and nutrient content, may down-regulate the motility of the digestive system, either via vagal and splachnic sensory pathways which mediate inhibition of gastric motility induced by duodenal distension [39] , or via cholecystokin-and secretin-mediated pathways [40] . Cholecystokinin (CKK) has been shown in animals and humans to inhibit gastric emptying (especially the liquidphase emptying of the stomach) [41] via a vagal capsaicinsensitive afferent pathway and by stimulating phasic and tonic pyloric motility [42][43][44][45] . Muller and associates [46] reported that CCK levels decrease from 1.1 ± 0.2 pmol/L preoperatively to 0.8 ± 0.2 pmol/L 10 d postoperatively, and to 0.5 ± 0.1 pmol/L following PPPD, though no statistical significance could be demonstrated.…”

Section: W H a T I S T H E P A T H O M E C H A N I S M Underlying Thementioning

confidence: 99%

Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: A review of the literature and critical reappraisal of the implicated pathomechanism

Paraskevas

Avgerinos²,

Manes³

et al. 2006

WJG

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Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the efficacy of a recently reported (but not yet tested in largescale studies) modification, that is, PPPD with antecolic duodenojejunostomy.

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Cholecystokinin octapeptide stimulates phasic and tonic pyloric motility in healthy humans.

Cited by 64 publications

References 19 publications

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Effect of Cholecystokinin-Octapeptide and Cerulein on Phasic and Tonic Components in Ovine Duodenum with Special Reference to the 'Minute Rhythm'

Delayed Gastric Emptying After Standard Pancreaticoduodenectomy Versus Pylorus-Preserving Pancreaticoduodenectomy: An analysis of 200 Consecutive Patients

Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: A review of the literature and critical reappraisal of the implicated pathomechanism

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