Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study

Záborszky, László; Alheid, George F.; Beinfeld, Margery C.; Eiden, Lee E.; Heimer, Lennart; Palkovits, Miklós

doi:10.1016/0306-4522(85)90302-1

Cited by 453 publications

(197 citation statements)

References 60 publications

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“…Neurochemically, the rostral shell has higher levels of D1 and D2 mRNA and opioid enkephalin mRNA (Bardo and Hammer, 1991;Voorn and Docter, 1992). In contrast, the caudal shell has higher levels of cholecystokinin, acetylcholinesterase, vasopressinoxytocin receptors, and greater norepinephrine and serotonin innervation (Zaborszky et al, 1985;Meredith et al, 1989;Zhou et al, 1991;Tribollet et al, 1992;Berridge et al, 1997;Veinante and Freund-Mercier, 1997;Delfs et al, 1998). These various neurochemical and neuroanatomical differences between rostral versus caudal shell may contribute to the functional differences we have reported here.…”

Section: Neurobiological Bases Of Rostrocaudal Shell Segregation Of Amentioning

confidence: 63%

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

2001

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This study examined localization of positive versus negative motivational functions mediated by GABA circuits within the accumbens shell. Microinjections of a GABA A agonist (0, 25, 75, and 225 ng/0.5 l muscimol) in rostral shell sites elicited appetitive increases in eating behavior. In contrast, microinjections in caudal shell sites elicited defensive burying or pawtreading behavior. Rats whose microinjections landed bilaterally outside of the accumbens shell did not display either behavior. Defensive treading elicited by caudal shell muscimol microinjection appeared to be a negative motivated response to threat (similar in parameters and orientation to normal defensive burying of a threatening electrified shock prod). The nucleus accumbens shell thus appears functionally heterogeneous in coding motivational valence. The demonstration that muscimol elicits positive eating behavior from rostral shell versus negative defensive behavior from caudal shell suggests in particular that GABAergic substrates of positive and negative types of motivated behavior in the nucleus accumbens shell are segregated along a rostrocaudal gradient.Key words: accumbens shell; GABA; food intake; reward; appetite; motivation; glutamate; dopamine; fear; defense; aggression; mesolimbic; microinjection GABAergic medium spiny neurons in the nucleus accumbens shell are implicated in the control of appetitive behavior and reward. Regarding eating behavior specifically, robust increases in food intake by rats are elicited by microinjection in the medial accumbens shell of either GABA A or GABA B receptor agonists (or non-NMDA glutamate antagonists) (Maldonado-Irizarry et al., 1995;Stratford and Kelley, 1997;Basso and Kelley, 1999).Aside from its role in positive appetitive behavior, the accumbens shell has also been implicated in negative motivational states, such as stress, fear, and defensive behavioral responses elicited by noxious or threatening stimuli (Inoue et al

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Section: Neurobiological Bases Of Rostrocaudal Shell Segregation Of Amentioning

confidence: 63%

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

2001

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“…Rats learn to self-administer D-amphetamine (Hoebel et al, 1983;Phillips et al, 1994), a dopamine releaser and uptake blocker, and other dopaminergic agents directly into the accumbens. The accumbens can be divided into the core and shell, a distinction that originates from the discovery of differential histochemical profile within the accumbens (Zaborszky et al, 1985). There is now ample evidence for functional heterogeneity between the two zones (Di Chiara, 2002;Kelley, 2004).…”

Section: Introductionmentioning

confidence: 99%

The Functional Divide for Primary Reinforcement of D-Amphetamine Lies between the Medial and Lateral Ventral Striatum: Is the Division of the Accumbens Core, Shell, and Olfactory Tubercle Valid?: Figure 1.

Ikemoto

Qin²,

Z³

2005

J. Neurosci.

112

110

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When projection analyses placed the nucleus accumbens and olfactory tubercle in the striatal system, functional links between these sites began to emerge. The accumbens has been implicated in the rewarding effects of psychomotor stimulants, whereas recent work suggests that the medial accumbens shell and medial olfactory tubercle mediate the rewarding effects of cocaine. Interestingly, anatomical evidence suggests that medial portions of the shell and tubercle receive afferents from common zones in a number of regions. Here, we report results suggesting that the current division of the ventral striatum into the accumbens core and shell and the olfactory tubercle does not reflect the functional organization for amphetamine reward. Rats quickly learned to self-administer D-amphetamine into the medial shell or medial tubercle, whereas they failed to learn to do so into the accumbens core, ventral shell, or lateral tubercle. Our results suggest that primary reinforcement of amphetamine is mediated via the medial portion of the ventral striatum. Thus, the medial shell and medial tubercle are more functionally related than the medial and ventral shell or the medial and lateral tubercle. The current core-shelltubercle scheme should be reconsidered in light of recent anatomical data and these functional findings.

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“…Enkephalin content in the VP arises almost exclusively from the medium spiny GABAergic projections from the NAc (Zaborszky et al, 1985;Zhou et al, 2003). The lack of effect by b-FNA suggests that this enkephalinergic tone within the VP is not critical for cocaine's rewarding effects in the present paradigm.…”

Section: Discussionmentioning

confidence: 73%

Mu-Opioid Receptor Alkylation in the Ventral Pallidum and Ventral Tegmental Area, but not in the Nucleus Accumbens, Attenuates the Effects of Heroin on Cocaine Self-Administration in Rats

Martin

Coller

et al. 2007

Neuropsychopharmacol

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The concurrent use of cocaine and heroin, often referred to as speedball, is a powerful reinforcer that has been reported in humans to sometimes result in heightened euphoria compared with either drug alone. Data from animal research indicate that the reinforcing efficacy of low doses of cocaine is potentiated by the addition of small amounts of heroin and that this potentiation is accompanied by synergistic increases in nucleus accumbens (NAc) extracellular fluid levels of dopamine. Although mu-and/or delta-opioid receptors may underlie this potentiation, the opioid receptor subtype or the loci responsible for this enhancement is not known. This experiment used intracranial administration of a selective mu-opioid receptor alkylating agent (beta-funaltrexamine (b-FNA)) to assess the role of m-opioid receptors in the NAc, ventral pallidum (VP), and ventral tegmental area (VTA) on the ability of heroin to alter cocaine self-administration. Rats were trained to self-administer cocaine, heroin, or their combination and were administered either vehicle or b-FNA into one of each brain region and the effects upon drug intake assessed. b-FNA administered into the VP or VTA shifted the dose-effect curve for the cocaine/heroin combination towards that maintained by cocaine alone. b-FNA had no effect on self-administration of the combination of cocaine and heroin when injected into the NAc. These data suggest that heroin may attenuate feedback inhibition from the NAc to the VP and VTA when co-self-administered with cocaine, resulting in a positive modulation of the effects of cocaine.

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Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study

Cited by 453 publications

References 60 publications

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

The Functional Divide for Primary Reinforcement of D-Amphetamine Lies between the Medial and Lateral Ventral Striatum: Is the Division of the Accumbens Core, Shell, and Olfactory Tubercle Valid?: Figure 1.

Mu-Opioid Receptor Alkylation in the Ventral Pallidum and Ventral Tegmental Area, but not in the Nucleus Accumbens, Attenuates the Effects of Heroin on Cocaine Self-Administration in Rats

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