Cholecystokinin and endogenous opioid peptides: Interactive influence on pain, cognition, and emotion

Hebb, Andrea L.O.; Poulin, Jean-François; Roach, Sean P.; Zacharko, Robert M.; Drolet, Guy

doi:10.1016/j.pnpbp.2005.08.008

Cited by 133 publications

(86 citation statements)

References 211 publications

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“…If the PCA button, tone, or other environmental cue comes to signal safety after surgery, one might expect a pattern of increasing demands for morphine, since pain relief and safety may be followed by activation of the CCK-induced antianalgesia system thereby increasing pain (i.e., the PCA morphine and CCK release operate at cross purposes). Cholecystokinin is also implicated in anxiety 46 and it underlies anxiety mediated hyperalgesia. 47,48 Administration of proglumide, a mixed CCK-A and B receptor antagonist reduces anxiety-induced facilitation of pain (i.e., nocebo hyperalgesia).…”

Section: Discussionmentioning

confidence: 99%

Locked out and still knocking: predictors of excessive demands for postoperative intravenous patient-controlled analgesia

Katz

Buis

Cohen

2008

Can J Anesth/J Can Anesth

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CAN J ANESTH 55: 2 www.cja-jca.org Februar y, 2008 Background: Psychosocial factors governing the use of postoperative, intravenous patient-controlled analgesia (PCA) have received little attention in spite of the fact that PCA is the most common modality for managing pain after surgery. The motivation behind requests for analgesia during lockout periods is not known. Unrelieved pain and need for pain medication are obvious reasons but other factors may be involved. The aim of the present study was to predict PCA lockout interval demands based on preoperative psychosocial factors.Methods: Approximately one week before major abdominal gynecologic surgery, 117 women completed the impact of events scale (IES) measuring intrusive thoughts and avoidant behaviours. Pain was measured by visual analogue scale at three, six, 12, 24 and 48 hr after surgery. Measures of anxiety and negative affect were obtained 24 and 48 hr after surgery. Cumulative morphine consumption and every PCA demand (drug delivered and not delivered) were downloaded from the PCA pump.Results: Multiple regression analyses revealed that preoperative intrusive thoughts and avoidant behaviours about the upcoming surgery positively predicted PCA lockout interval demands after controlling for postoperative pain, morphine consumption, anxiety, and negative affect (R 2 = 0.45; P < 0.0001). Path analysis showed a direct pathway from preoperative IES scores to lockout interval demands (β = 0.23, P = 0.002) which was not associated with untreated pain, anxiety, or negative affect. Conclusions:Excessive demands for postoperative intravenous-PCA morphine during lockout intervals appear to reflect, in part, poor preoperative adaptation to surgery involving intrusive thoughts and avoidant behaviours about the upcoming surgery.

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Section: Discussionmentioning

confidence: 99%

Locked out and still knocking: predictors of excessive demands for postoperative intravenous patient-controlled analgesia

Katz

Buis

Cohen

2008

Can J Anesth/J Can Anesth

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“…[1][2][3][4][5] It was discovered 80 years ago and comprises 33 amino acids; CCK octapeptide (CCK8) and CCK tetrapeptide (CCK4), comprising 8 and 4 amino acids, respectively, have also been identified in living * To whom correspondence should be addressed: Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-shi, Chiba 274-8510, Japan. Phe-NH 2 ) accounts for 60% of the CCK family expressed in the human body and exhibits stronger activity than CCK33; in rats, it induces gallbladder contraction and amylase secretion in the pancreatic acini.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Binding Assay of 31Methionine-oxidized Cholecystokinin Octapeptide to the CCKB Receptor

Ichiba

Nakamoto

Yajima

et al. 2009

JOURNAL OF HEALTH SCIENCE

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“…CCK binds to CCK receptor-1 (CCKR-1) and CCKR-2, of which the CCKR-2 is predominantly found in the brain with the highest level in cortical area and the limbic system [97], a brain region that is critically involved in emotion response and behavior. Virtually, the CCKergic system has long been recognized as an anxiogenic factor for the animals [98], and this effect has been well validated in human populations as well [89,99,100]. Our recent study also showed that overexpression of CCKR2 in neurons of the forebrain of mice significantly enhanced ALBs [101].…”

Section: Introductionmentioning

confidence: 54%

CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS)

Tang¹,

Joseph²,

Chen³

et al. 2012

Glucocorticoids - New Recognition of Our Familiar Friend

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Cholecystokinin and endogenous opioid peptides: Interactive influence on pain, cognition, and emotion

Cited by 133 publications

References 211 publications

Locked out and still knocking: predictors of excessive demands for postoperative intravenous patient-controlled analgesia

Locked out and still knocking: predictors of excessive demands for postoperative intravenous patient-controlled analgesia

In Vitro Binding Assay of 31Methionine-oxidized Cholecystokinin Octapeptide to the CCKB Receptor

CCKergic System, Hypothalamus-Pituitary-Adrenal (HPA) Axis, and Early-Life Stress (ELS)

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