Cholecystitis secondary to infusion chemotherapy

Pietrafitta, Joseph J.; Anderson, Bernhard G.; O’Brien, Michael; Deckers, Peter J.

doi:10.1002/jso.2930310413

Cited by 13 publications

(6 citation statements)

References 5 publications

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“…In patients with other malignancies, the considerations for concomitant cholecystectomy are slightly different, because the likelihood of these patients developing late biliary morbidities is higher with adjuvant chemotherapy, which causes drug toxicity-related cholestasis or cholecystitis [16]. Furthermore, although none of the patients who underwent later cholecystectomy experienced any morbidity in this study, acute cholecystitis occurring postoperatively has been reported dangerous because of hindered diagnosis and technical difficulties in a previously operated field [17,18].…”

Section: Discussionmentioning

confidence: 78%

Incidental Cholecystectomy in Patients with Asymptomatic Gallstones Undergoing Surgery for Colorectal Cancer

et al. 2015

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Background and Aims: The feasibility of incidental cholecystectomy during colorectal cancer (CRC) surgery has not been determined as yet. We aimed to investigate the feasibility of incidental cholecystectomy during CRC surgery. Methods: The clinicopathologic data of patients who underwent CRC surgery between January 2004 and May 2011 were assessed. Patients with asymptomatic cholelithiasis were divided into groups that did and did not undergo incidental cholecystectomy. Their in-hospital morbidity and long-term biliary complications were compared. Results: Of the 282 patients identified, 143 (50.7%) underwent incidental cholecystectomy and 139 (49.3%) were observed without cholecystectomy. The two groups were similar in clinical characteristics, except for gender and operation time. Only one patient (0.7%) in the cholecystectomy group experienced an intraoperative biliary complication. There was no significant difference in overall in-hospital morbidity between the two groups. After a median follow-up period of 33 months, long-term biliary complications developed in 12 patients (8.6%) in the observation group, with 9 undergoing cholecystectomy. Conclusions: Incidental cholecystectomy was not associated with increased postoperative morbidity, whereas previously asymptomatic patients were at substantial long-term risk of becoming symptomatic. Thus, in the absence of clear contraindications, concomitant cholecystectomy might be a desirable treatment option during CRC surgery in patients with asymptomatic gallstones.

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Section: Discussionmentioning

confidence: 78%

Incidental Cholecystectomy in Patients with Asymptomatic Gallstones Undergoing Surgery for Colorectal Cancer

et al. 2015

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“…Early surgical literature regarding hepatic arterial infusion pumps showed that chemotherapy alone can cause chemical cholecystitis. 13 Although no studies have been performed specifically studying lobar TACE versus selective or superselective TACE, the rate of acute cholecystitis may be higher after lobar TACE should there be nontarget delivery of chemotherapy to the cystic artery. In the study by Wagnetz et al 11 discussed above, the incidence of acute cholecystitis with TACE was 4.9% with the majority of patients treated via a lobar approach.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Arterial Embolization Complicated by Acute Cholecystitis

Shah

Brown²

2011

Semin intervent Radiol

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Hepatic arterial embolization (HAE) is a treatment used in the management of primary and some metastatic hepatic tumors. Complications of HAE are similar to those seen in other treatments, particularly transcatheter arterial chemoembolization (TACE), but without the possibility for chemotherapy related side effects. Particle reflux into the cystic artery is generally clinically occult but gallbladder ischemia severe enough to require cholecystostomy tube placement can occur. The authors discuss the case of a patient who underwent HAE and subsequently required a cholecystostomy tube due to development of acute cholecystitis.

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“…In studies on patients treated with percutaneously placed catheters, chemical cholecystitis was not identified (Niederhuber & Ensminger 1983;Pietrafitta et al 1986). Carrasco et al (1983) reported only 4 cases of cholecystitis in a series of 700 treated patients, of whom only 2 underwent cholecystectom y.…”

Section: Clinical Datamentioning

confidence: 99%

“…Lafon et al (1985) reported biliary symptoms requiring surgery in all 6 patients who underwent pump implantation and who had no prophylactic cholecystectomy. Pietrafitta et al (1986) reported 1 case out of 8. Ottery et al (1986) reported 2 patients developing symptomatic cholecystitis necessitating cholecystectomy out of a total of 6.…”

Section: Clinical Datamentioning

confidence: 99%

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Drug-Induced Gallbladder Disease

1992

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A great variety of drugs is reported to induce gallbladder disease by various pathogenetic mechanisms. Early epidemiological studies indicated a doubled risk of gallbladder disease in women taking oral contraceptives. More recent studies, however, have failed to confirm those findings; these conflicting results might be explained by the different methods used to define gallbladder disease. It was shown that the lithogenic index of the bile is increased during intake of oral contraceptives. Estrogens cause hypersecretion of cholesterol in bile, due to increase in lipoprotein uptake by the hepatocyte. Progesterone inhibits acyl coenzyme A-cholesterol acyl transferase (ACAT) activity, causing delayed conversion of cholesterol to cholesterol esters. Of the lipid lowering drugs, only clofibrate has been shown to increase the risk for gallstone formation. The other fibric acid derivatives have similar properties, but clinical experience is not as extensive. They seem to be inhibitors of the ACAT enzyme system, thereby rendering bile more lithogenic. Conflicting epidemiological data exist regarding the induction of acute cholecystitis by thiazide diuretics. Ceftriaxone, a third-generation cephalosporin, is reported to induce biliary sludge in 25 to 45% of patients, an effect which is reversible after discontinuing the drug. The sludge is occasionally a clinical problem. It was clearly demonstrated that this sludge is caused by precipitation of the calcium salt of ceftriaxone excreted in the bile. Long term use of octreotide is complicated by gallstone formation in approximately 50% of patients after 1 year of therapy, due to gallbladder stasis. Hepatic artery infusion chemotherapy by implanted pump is shown to be associated with a very high risk of chemically induced cholecystitis. Prophylactic cholecystectomy at the time of pump implantation is therefore advocated. Some drugs, such as erythromcyin or ampicillin, are reported to cause hypersensitivity-induced cholecystitis. Furthermore, there are reports on the influence of cyclosporin, dapsone, anticoagulant treatment, and narcotic and anticholinergic medication in causing gallbladder disease.

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Cholecystitis secondary to infusion chemotherapy

Cited by 13 publications

References 5 publications

Incidental Cholecystectomy in Patients with Asymptomatic Gallstones Undergoing Surgery for Colorectal Cancer

Incidental Cholecystectomy in Patients with Asymptomatic Gallstones Undergoing Surgery for Colorectal Cancer

Hepatic Arterial Embolization Complicated by Acute Cholecystitis

Drug-Induced Gallbladder Disease

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