Cholécystite xanthogranulomateuse : diagnostic et prise en charge

Xanthogranulomatous cholecystitis: Diagnostic dilemma and surgical solution in geriatric patients: A case report

“…Xanthogranulomatous cholecystitis (XGC) is a rare inflammatory disease of the gallbladder characterized by severe proliferation of fibrotic tissue accompanied by the accumulation of lipid-laden macrophages and acute and chronic inflammatory cells [ 1 ]. Despite being benign, XGC often extends into neighboring organs, and its macroscopic appearance may be mistaken for gallbladder cancer [ 1 , 5 ].…”

“…However, intraoperative differentiation between XGC and GB carcinoma remains challenging, especially in cases of tumor formation and adhesions to adjacent organs [ 12 ]. Intraoperative frozen section analysis is useful in distinguishing between XGC and gallbladder cancer, helping to avoid unnecessarily extended surgery [ 1 ]. Given the possibility of coexistence between GBC and XGC, radical resection, such as liver resection, may be justified when malignancy cannot be completely excluded [ 6 ].…”

“…Xanthogranulomatous cholecystitis (XGC) is a rare inflammation of the gallbladder characterized by the presence of xanthogranulomas, which are yellow structures within the gallbladder wall often associated with gallstones [ 1 ]. In some cases, XGC can resemble gallbladder carcinoma (GBC), especially when it takes on a pseudo-tumoral form and affects nearby organs [ 1 ]. The development of XGC involves inflammation that damages the Rokitansky-Aschoff sinuses in the gallbladder wall, leading to an intense inflammatory reaction [ 1 ].…”

“…In some cases, XGC can resemble gallbladder carcinoma (GBC), especially when it takes on a pseudo-tumoral form and affects nearby organs [ 1 ]. The development of XGC involves inflammation that damages the Rokitansky-Aschoff sinuses in the gallbladder wall, leading to an intense inflammatory reaction [ 1 ]. The actual incidence of XGC is unknown, ranging from 0.7 % to 13.2 % of all inflammatory pathologies of the gallbladder [ 2 ].…”