Cholecalciferol Supplements Improve Vitamin D Deficiency in Renal Transplant Recipients

Background: Vitamin D’s role is noticeable on homeostasis of calcium and phosphorous and bone mineralization. Some studies prove that vitamin D has a role in reproductive pathways in male and females and its direct relationship with serum androgen levels in males. The common problem of infertility can be seen in 10%−15% of couples. 25%−50% of all infertilities is due to a male factor, and fertility disturbances are common in male CKD patients. Objectives: This study aimed to figure out the effect of serum vitamin D levels on semen analysis parameters and reproductive hormones before and after renal transplantation in ESRD patients. Methods: This double-blind randomized clinical trial was carried out on 70 ESRD males (21–48 years old) who were candidates for renal transplantation at Sina hospital between 2021 and 2022. Participants were divided into two groups randomly. First group was supplemented by vitamin D (50,000 units weakly until 3 months), and no intervention was done in the second group. Vitamin D levels, LH, FSH, creatinine, glomerular filtration rate (GFR), calcium, total and free testosterone, PTH, sexual function, and semen analysis parameters were evaluated in a determined interval before and after (three and 6 months) kidney transplantation Results: Vitamin D levels were noticeably higher in case group in comparison to the control group ( p-value < 0.01) but the difference in all other variables including calcium levels, LH, FSH, total and free testosterone, IIEF-5 score, PTH, GFR, and creatinine was insignificant ( p-value > 0.05). The comparison of semen parameters of the case with control group including sperm count, morphology, volume, and motility didn’t reveal a noticeable difference between the two groups ( p-value > 0.05). Conclusion: Prescription of vitamin D as a supplementation doesn’t improve sperm quality (sperm count, motility, morphology, and volume) and reproductive hormones (LH, FSH, free and total testosterone) after kidney transplantation in male CKD patients.

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“…It is implicated that the outcomes of renal transplantation are also related to vitamin D status before transplantation. 7–11…”

Section: Introductionmentioning

confidence: 99%

“…It is implicated that the outcomes of renal transplantation are also related to vitamin D status before transplantation. [7][8][9][10][11] Vitamin D levels have a direct relationship with serum androgen levels in males. Activated forms of vitamin D and its agonists play their physiologic roles by attaching to vitamin D receptors (VDR).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the relationship between vitamin D with semen analysis parameters and reproductive hormones levels before and after kidney transplantation: An Iranian randomized and double-blinded study

et al. 2023

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Interventions for preventing bone disease in kidney transplant recipients

Palmer

Chung

McGregor

et al. 2019

Cochrane Database of Systematic Reviews

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Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients

et al. 2011

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Vitamin D deficiency is common in adult renal transplant recipients, but data in children are scarce. Vitamin D is shown to have multiple effects on the cardiovascular system, renal function, and maintenance of bone health. We hypothesized that 25(OH)D deficiency is common in pediatric renal transplant recipients, and may be associated with hyperparathyroidism, short stature, renal function, and blood pressure control. We recruited 106 children during the winter/spring season who had a functioning renal transplant for at least 3 months. Twenty-five hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] were measured and correlated with clinical and biochemical parameters. Of the renal transplant patients, 38% were 25(OH)D deficient, 54% had insufficient levels, and only 8% had adequate 25(OH)D levels. Despite alfacalcidol supplementation in 59 (56%) patients, parathyroid hormone was increased in 58 (55%) and showed an inverse correlation with 25(OH)D (p = 0.0003, r = 0.61) but not with 1,25(OH)(2)D levels. Height standard deviation score (SDS) correlated with 25(OH)D (p = 0.007, r = 0.42) and time post transplantation (p = 0.02, r = 0.23); both were significant and independent predictors of height SDS. 25(OH)D inversely correlated with systolic BP SDS (p = 0.02, r =-0.26); this association was lost on multiple regression analysis, but 25(OH)D was the only modifiable risk factor for hypertension. There was no correlation with estimated GFR or proteinuria. In conclusion, 25(OH)D deficiency is common in pediatric renal transplant recipients and correlates with hyperparathyroidism and short stature. 25(OH)D deficiency may be a modifiable risk factor for hypertension in transplant recipients. Further studies are required to test if routine supplementation with ergo or cholecalciferol is safe and effective in children after renal transplantation.

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Cholecalciferol Supplements Improve Vitamin D Deficiency in Renal Transplant Recipients

Cited by 9 publications

References 5 publications

Assessment of the relationship between vitamin D with semen analysis parameters and reproductive hormones levels before and after kidney transplantation: An Iranian randomized and double-blinded study

Assessment of the relationship between vitamin D with semen analysis parameters and reproductive hormones levels before and after kidney transplantation: An Iranian randomized and double-blinded study

Interventions for preventing bone disease in kidney transplant recipients

Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients

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