Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency

Pang, Yong; Sun, Liang; Xiong, Quan; Xu, Xinming; Lin, Xu

doi:10.1093/jn/nxy032

Cited by 8 publications

(15 citation statements)

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“…27 With regard to BTMs, only few studies have investigated the relation between vitamin D 3 administration and P1NP and CTX-1 and especially data from rat studies are limited. While long-term human studies involving vitamin D supplementation have shown consistent increases in 25-hydroxy vitamin D 3 , but varying effects on BTMs, 28–30 results from acute studies involving higher doses of vitamin D 3 show a response on P1NP and CTX-1 within 4 hours 31 and a peak around day 2–3. 32 This could imply that measurements of BTMs are most relevant within the first few days of vitamin D administration, which should be considered for future studies.…”

Section: Resultsmentioning

confidence: 98%

Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats

Jakobsen

Ditzel

et al. 2022

Food Funct.

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Section: Resultsmentioning

confidence: 98%

Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats

Jakobsen

Ditzel

et al. 2022

Food Funct.

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“…In total, 17 studies involving intervention with vitamin D supplements were identified, which are presented in Table 1 . Participants’ (n = 4482) mean age varied from 43 to 75 years, and the durations of the studies ranged from 8 weeks to 3 years [ 18 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. In seven studies, only females were included [ 18 , 32 , 33 , 34 , 35 , 36 , 37 ], in two studies, only males were included [ 38 , 39 ], while in the remaining eight studies, both sexes were included [ 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

et al. 2023

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Osteoporosis is a common disease, defined primarily by a low measured bone density, which is associated with an increased risk of fragility fractures. Low calcium intake and vitamin D deficiency seem to be positively correlated with the prevalence of osteoporosis. Although they are not suitable for the diagnosis of osteoporosis, the biochemical markers of bone turnover can be measured in serum and/or urine, enabling the assessment of the dynamic bone activity and the short-term effectiveness of the osteoporosis treatment. Calcium and vitamin D are essential for maintaining bone health. The aim of this narrative review is to summarize the effects of vitamin D and calcium supplementation separately and in combination, on bone density and circulating serum and blood plasma vitamin D, calcium, parathyroid hormone levels, markers of bone metabolism concentrations, and clinical outcomes, such as falls and osteoporotic fractures. We searched the PubMed online database to find clinical trials from the last five years (2016–April 2022). A total of 26 randomized clinical trials (RCTs) were included in this review. The present reviewed evidence suggests that vitamin D alone or in combination with calcium increases circulating 25(OH)D. Calcium with concomitant vitamin D supplementation, but not vitamin D alone, leads to an increase in BMD. In addition, most studies did not detect significant changes in circulating levels of plasma bone metabolism markers, nor in the incidence of falls. Instead, there was a decrease in blood serum PTH levels in the groups receiving vitamin D and/or Ca supplementation. The plasma vitamin D levels at the beginning of the intervention, and the dosing regimen followed, may play a role in the observed parameters. However, further study is needed to determine an appropriate dosing regimen for the treatment of osteoporosis and the role of bone metabolism markers.

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“…For example, in one study involving Chines adults, vitamin D supplementation increased serum levels of bone alkaline phosphatase, but did not affect PINP and CTX levels. However, in subjects whose 25(OH)D concentration exceeded 30 ng/ml, an increase of CTX levels was observed [21]. Conversely, it has been demonstrated that improved vitamin D status in younger postmenopausal women leads to a signi cant reduction in serum CTX and PINP levels [22].…”

Section: Response To Want and Vitamin Dmentioning

confidence: 99%

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Mieszkowski

Kochanowicz

Piskorska

et al. 2021

Preprint

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Purpose/Introduction: To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods: Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption.Results: UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion: Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

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Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency

Abstract: Daily supplementation with 2000 IU cholecalciferol for 20 wk may promote bone formation in Chinese adults with vitamin D deficiency. More studies are needed to elucidate the potential clinical implications of BTMs. This trial was registered at clinicaltrials.gov as NCT01998763.

Cited by 8 publications

References 26 publications

Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats

Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

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Cholecalciferol Supplementation Promotes Bone Turnover in Chinese Adults with Vitamin D Deficiency

Abstract: Daily supplementation with 2000 IU cholecalciferol for 20 wk may promote bone formation in Chinese adults with vitamin D deficiency. More studies are needed to elucidate the potential clinical implications of BTMs. This trial was registered at clinicaltrials.gov as NCT01998763.

Cited by 8 publications

References 26 publications

Administration of whey protein complexed vitamin D3 to vitamin D3-deficient growing Sprague-Dawley rats

Administration of whey protein complexed vitamin D3 to vitamin D3-deficient growing Sprague-Dawley rats

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

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Product

Resources

About

Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats

Administration of whey protein complexed vitamin D₃ to vitamin D₃-deficient growing Sprague-Dawley rats