Cholecalciferol Supplementation Does Not Influence β-Cell Function and Insulin Action in Obese Adolescents: A Prospective Double-Blind Randomized Trial,

Javed, Asma; Vella, Adrian; Balagopal, Prabhakaran; Fischer, Philip R.; Weaver, Amy L.; Piccinini, Francesca; Man, Chiara Dalla; Cobelli, Claudio; Giesler, Paula D.; Laugen, Jeanette M.; Kumar, Seema

doi:10.3945/jn.114.202010

Cited by 41 publications

(45 citation statements)

References 45 publications

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“…21 Nevertheless, it should be acknowledged that the majority of trials failed to demonstrate a consistent and clinically meaningful benefit of vitamin D treatment on glycaemic control in diabetes mellitus, [41][42][43][44][45][46] glucose intolerance 22,[25][26][27][28][29][30][31]47 or in other cohorts. [48][49][50][51][52][53][54][55] In recent meta-analyses and systematic reviews, this led to the notion that there is currently no evidence to support a routine correction of vitamin D insufficiency in patients with diabetes mellitus or glucose intolerance. 7,8,18,19,56,57 Nevertheless, the heterogeneity between the different trials, especially with regard to dose, treatment duration and ethnicity, leaves the possibility that there are certain subgroups of patients who might benefit from vitamin D supplementation.…”

Section: Resultsmentioning

confidence: 99%

“…Also, in an older white population with impaired fasting glucose, 700 IU of vitamin D for 3 years attenuated the change in fasting glucose and HOMA‐IR . Nevertheless, it should be acknowledged that the majority of trials failed to demonstrate a consistent and clinically meaningful benefit of vitamin D treatment on glycaemic control in diabetes mellitus, glucose intolerance or in other cohorts . In recent meta‐analyses and systematic reviews, this led to the notion that there is currently no evidence to support a routine correction of vitamin D insufficiency in patients with diabetes mellitus or glucose intolerance .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial

Grübler

Gaksch

Kienreich

et al. 2016

Diabetes Obesity Metabolism

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial

Grübler

Gaksch

Kienreich

et al. 2016

Diabetes Obesity Metabolism

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show abstract

“…Javed and al. [4] showed no effect of VD supplementation (2000 IU maximal dose) on insulin activity in non-diabetic adolescents with obesity without VD insufficiency. On the other hand, Belenchia and al.…”

Section: Introductionmentioning

confidence: 84%

Effect of Vitamin D Supplementation on Cardiometabolic Factors and Inflammatory Status in Adolescents with Obesity Enrolled in a Weight-Loss Program

Morrissey¹,

Perez-Martin²,

Defoort³

et al. 2019

Preprint

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Obesity in children is associated with vitamin D (VD) deficiency and cardiometabolic abnormalities. To analyze the effects of VD supplementation in adolescents with obesity enrolled in a weight-loss program. Adolescents with obesity (n=26) and with normal weight (n=23; controls) were matched for age, sex, and puberty stage. The obesity group followed a 3-month weight-loss program that combined a reduced caloric intake with interval training physical activity and during which they received or not VD supplementation (4000 IU/d) (n=13/group; random assignation). The anthropometric parameters (BMI z-score, fat mass); serum levels of 25(OH)D, calcium and parathyroid hormone (PTH), cardiometabolic factors (triglycerides, HDL, and LDL cholesterol), fasting glucose and insulin, and homeostasis model assessment of insulin resistance index; diastolic, systolic and mean blood pressure, and inflammatory status (C-reactive protein, CRP) were measured at baseline and at the end of the 3-month program. At baseline, 25(OH)D concentration was lower and VD insufficiency (25(OH)D levels <50 nmol/L) rate was higher (73% vs 22%) in the obesity than in the normal-weight group. All cardiometabolic factors were altered in the obesity compared with the normal-weight group. After the 3-month weight-loss program, 25(OH)D levels was >50 nmol in all adolescents with obesity, but only in 46% of normal-weight adolescents. Moreover, the weight-loss program improved the cardiometabolic factors, inflammatory status (CRP) and physical performance, but VD supplementation did not have any additional effect. Analysis only of the adolescents with obesity and VD deficiency (25(OH)D <50 nmol/L) at baseline showed a significant correlation between the change in PTH and CRP (p=0.02) in the supplemented obesity group, while the increase in 25(OH)D only tended to be correlated with CRP decrease. Vitamin D supplementation could reduce VD insufficiency in adolescent with obesity, but does not have any additional effect on cardiometabolic factors when combined with a weight-loss program.

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“…While higher VitD status is associated with better β-cell function among those with T2D [60•, 61], it is not a predictor of diabetes incidence, and adequate VitD levels do not protect against the development of T2D [62]. VitD supplementation in individuals already sufficient in VitD seems to have no effect on insulin secretion [63]. It appears that due to its involvement in insulin secretion, VitD as a treatment is only effective at increasing insulin secretion in populations with VitD deficiencies or other syndromes, such as parathyroid hormone deficiency and T2D [64•, 65, 66].…”

Section: Vitamin Dmentioning

confidence: 98%

Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion

et al. 2015

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Approximately 366 million people worldwide have been diagnosed with type-2 diabetes (T2D). Chronic insulin resistance, decreased functional β-cell mass, and elevated blood glucose are defining characteristics of T2D. Great advances have been made in understanding the pathogenesis of T2D with respect to the effects of dietary macronutrient composition and energy intake on β-cell physiology and glucose homeostasis. It has been further established that obesity is a leading pathogenic factor for developing insulin resistance. However, insulin resistance may not progress to T2D unless β-cells are unable to secret an adequate amount of insulin to compensate for decreased insulin sensitivity. Therefore, pancreatic β-cell dysfunction plays an important role in the development of overt diabetes. This paper reviews recent research findings on the effects of several micronutrients (zinc, vitamin D, iron, vitamin A), leucine, and the phytochemical, genistein on pancreatic β-cell physiology with emphasis on their effects on insulin secretion, specifically in the context of T2D.

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Cholecalciferol Supplementation Does Not Influence β-Cell Function and Insulin Action in Obese Adolescents: A Prospective Double-Blind Randomized Trial,

Cited by 41 publications

References 45 publications

Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial

Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial

Effect of Vitamin D Supplementation on Cardiometabolic Factors and Inflammatory Status in Adolescents with Obesity Enrolled in a Weight-Loss Program

Beta Cell Function and the Nutritional State: Dietary Factors that Influence Insulin Secretion

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