Cholangitis with Sphingobacterium multivorum and Acinetobacter junii bacteremia in a patient with gastric cancer: A case report

Akazawa, Nana; Morioka, Hiroshi; Ogata, Takatsugu; Ishibana, Yuichi; Murakami, Hiromi; Narita, Yukiya

doi:10.1016/j.jiac.2022.06.005

Cited by 3 publications

(4 citation statements)

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“…Sphingobacterium multivorum and S. spiritivorum were recognised from a limited number of cases that had been previously published. According to Lambiase et al 4 , 5 sputum from individuals with cystic fibrosis was utilized in the process of isolating S. multivorum and S. spiritivorum . It was just recently discovered that an elderly patient was the first human to ever get an infection caused by Sphingobacterium hotanense.…”

Section: Discussionmentioning

confidence: 99%

Section: Molecular Docking Of Chimeric Protein With Tlr4mentioning

confidence: 99%

“…The source of infection in the case of the patient with extrinsic allergic alveolitis was identified as a bacterial strain that was isolated from the patient’s sputum and came from a water reservoir inside his steam iron. 5 …”

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confidence: 99%

“…The source of infection in the case of the patient with extrinsic allergic alveolitis was identified as a bacterial strain that was isolated from the patient's sputum and came from a water reservoir inside his steam iron. 5 In the past, antibiotic therapy with cephalosporins or a combination of penicillin or ciprofloxacin was the primary treatment. The majority of Sphingobacterium are naturally resistant to polymyxin B and aminoglycosides.…”

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confidence: 99%

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Development of a candidate multi-epitope vaccine againstSphingobacterium spiritivorum

Alamri

2023

SMJ

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Objectives: To develop a candidate vaccine aginst the Sphingobacterium spiritivorum . Methods: Since there is currently no vaccine against this pathogen, we employed in-silico methods to extensively explore the outer membrane toxin-producing proteins found specifically in S. spiritivorum to forecast a multi-epitope chimeric vaccine design. This computational study was conducted in Saudi Arabia in 2022 (study design: computational; ethical approval not applicable). Results: TThe vaccine peptide comprises multiple linear and conformational B-cell epitopes, which have the potential to elicit humoral immunity. Projected B-cell- derived T-cell epitopes for outer membrane proteins are present in the produced protein. The docking and molecular dynamic simulation results indicating that the chimeric vaccine had adequate binding stability with TLR-4. Following the immunological simulation, significant levels of immune cell expression were observed as immunoglobulin (Ig) M and IgG, IgM, IgM1, and IgM2, and independently IgG1 and IgG2. Conclusion: The developed vaccine candidate is suitable for further testing and can assist experimental vaccinologists in developing an effective vaccine against S. spiritivorum .

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Section: Discussionmentioning

confidence: 99%

Section: Molecular Docking Of Chimeric Protein With Tlr4mentioning

confidence: 99%

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