Cholangiocyte RAGE drives the ductular reaction which provides biliary drainage but fuels liver injury
Nachiket Vartak,
Amruta Damle-Vartak,
Simone Joers
et al.
Abstract:Ductular reactions inevitably co-occur with liver tissue injury along with inflammation, cholestasis, and fibrosis. However, it remains unknown whether they represent an adaptive response facilitating bile drainage, or if they exacerbate dysfunction. By using a reporter mouse with cholangiocyte-specific deletion of the pattern recognition receptor RAGE, specific effects of the DR could be differentiated from the consequences of the cytotoxicity of the CDE-diet. While CDE-diet induced hepatoxicity triggers the … Show more
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