Cholangiocarcinoma: Update and future perspectives

Gatto, Maria Chiara; Bragazzi, Maria Consiglia; Semeraro, R.; Napoli, Cristina; Gentile, Raffaele; Torrice, A.; Gaudio, Eugenio; Alvaro, Domenico

doi:10.1016/j.dld.2009.12.008

Cited by 162 publications

(120 citation statements)

References 148 publications

Supporting

Mentioning

117

Contrasting

Order By: Relevance

“…7 The carbohydrate antigen CA-19-9 is widely used for diagnosis of CCA, but it lacks specificity, because it is also a marker for pancreatic cancer, gastric cancer, and primary biliary cirrhosis and is elevated in smokers. 11 Carcinoembryonic antigen, a marker for colorectal cancer, is elevated in approximately 30% of CCA patients. 12,13 Some potential biomarkers for CCA are trypsinogen-2, 14 mucin-5AC, and the soluble fragment of cytokeratin 19, although none are currently in clinical use.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors for Opisthorchis viverrini and Minute Intestinal Fluke Infections in Lao PDR, 2009–2011

Yoon¹,

Ki²,

Eom³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. The purpose of this report is to compare the prevalence of Opisthorchis viverrini/minute intestinal fluke (Ov/MIF) in Lao People's Democratic Republic according to different regions and evaluate the effect of ingestion of raw freshwater fish on the infection. Demographic data, behavioral data, and symptoms were obtained, and the Kato-Katz method was used for the diagnosis of Ov/MIF. In total, 3,046 individuals were enrolled. The risk factors associated with acquisition of Ov/MIF were raw fish consumption and province. Khong Island showed the highest prevalence (odds ratio = 80.1, 95% confidence interval = 47.9-133.9, P 0.001) compared with other districts, and raw fish consumption was related to Ov/MIF infection. Administration of praziquantel to entire populations, education (avoiding consumption of raw food dishes and improved hygiene), and access to clean water and sanitation should be considered.

show abstract

Section: Resultsmentioning

confidence: 99%

Risk Factors for Opisthorchis viverrini and Minute Intestinal Fluke Infections in Lao PDR, 2009–2011

Yoon¹,

Ki²,

Eom³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…It is the second most common primary hepatic malignancy after hepatocellular cancer, contributing to approximately 10-25% of all hepatobiliary malignancies (Blechacz et al, 2008;Sripa et al, 2008;Gatto et al, 2010). The incidence of CC varies enormously by geographic region and demographic diversity, with the highest incidence in Southeast Asia and the lowest in Australia (Shaib et al, 2004;Sripa et al, 2008;Barusrux et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Klatskin tumor, i.e Hilar CC, is typically classified as extrahepatic (Tyson et al, 2011). The clinical distinction between ICC and ECC has become significantly crucial due to their possibly different epidemiological characteristics (Patel., 2006;Gatto et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Bowel Disease and Risk of Cholangiocarcinoma: Evidence from a Meta-analysis of Population-based Studies

Huai¹,

Ding²,

Ye³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…2,4,5,7 In contrast, prognosis and survival of patients with intrahepatic cholangiocarcinoma is significantly worse than hepatocellular carcinoma. 5,8,9 Lymph node dissection is routinely performed during resection of intrahepatic cholangiocarcinoma but not hepatocellular carcinoma, as lymph node metastasis is relatively uncommon in the latter. 10,11 Treatment options for unresectable hepatocellular carcinoma include sorafenib and intra-arterial chemoembolization, whereas chemotherapeutic agents such as gemcitabine and fluoropyramidines are not beneficial.…”

mentioning

confidence: 99%

Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma

et al. 2013

View full text Add to dashboard Cite

Scirrhous hepatocellular carcinoma is a rare ill-defined morphological subtype of hepatocellular carcinoma characterized by marked stromal fibrosis. This variant can be difficult to distinguish from intrahepatic cholangiocarcinoma and metastatic adenocarcinoma, especially on needle biopsies. We performed immunohistochemistry for hepatocellular and adenocarcinoma-associated markers on 20 scirrhous hepatocellular carcinoma cases and compared the results with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Scirrhous hepatocellular carcinomas were significantly less likely to be HepPar-1 positive than classical hepatocellular carcinomas (26% and 74%, respectively; Po0.001) and were significantly more likely to express adenocarcinoma-associated markers such as epithelial cell adhesion molecule (63 vs 11%; Po0.001), cytokeratin 19 (26 vs 2%; Po0.001), and cytokeratin 7 (53 vs 2%; Po0.001). At least one of these adenocarcinoma-related markers was positive in 80% of scirrhous hepatocellular carcinoma cases. Glypican 3 and arginase were positive in 79% and 85% of cases of scirrhous hepatocellular carcinoma, respectively; the combined use of these two markers yielded 100% sensitivity for scirrhous hepatocellular carcinoma. In conclusion, the scirrhous morphology, absence of HepPar-1 staining, and frequent positivity with adenocarcinoma-related markers in scirrhous hepatocellular carcinoma can lead to an erroneous diagnosis of adenocarcinoma. Glypican 3 and arginase are the most reliable markers for identifying hepatocellular differentiation in this setting.

show abstract

Cholangiocarcinoma: Update and future perspectives

Cited by 162 publications

References 148 publications

Risk Factors for Opisthorchis viverrini and Minute Intestinal Fluke Infections in Lao PDR, 2009–2011

Risk Factors for Opisthorchis viverrini and Minute Intestinal Fluke Infections in Lao PDR, 2009–2011

Inflammatory Bowel Disease and Risk of Cholangiocarcinoma: Evidence from a Meta-analysis of Population-based Studies

Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma

Contact Info

Product

Resources

About