Cholangiocarcinoma in Hepatolithiasis

Intrahepatic cholangiocarcinoma in hepatolithiasis: A frequently overlooked disease

“…In this series, five cases of cholangiocarcinoma were found among 101 cases of hepatolithiasis ( 5 % ) between December 1987 and December 1988. Most hepatolithiases are located in the left intrahepatic duct [2,3, lo]; this type of cholangiocarcinoma also usually occurs in the left intrahepatic duct [8,9]. Among the five cases of this series, stones were located in the left duct in four patients and in bilateral ducts in one patient.…”

“…Cholangiocarcinoma is said to be rarely found in hepatolithiasis. However, this phenomenon does exist [5][6][7][8][9][10]. Recently, five patients with cholangiocarcinoma among 10 1 cases of hepatolithiasis (5%) between December 1987 and December 1988 were treated at Chang-Gung Memorial Hospital at Kaohsiung in southern Taiwan.…”

What is the impact of coexistence of hepatolithiasis on cholangiocarcinoma?

“…The incidence of hepatolithiasis with cholangiocarcinoma is reported to be 4–11% of the total cases of hepatolithiasis: 2–11 not as rare as previously considered 3,4 , 12,13 . There have been few studies on the influence of hepatolithiasis on the occurrence of cholangiocarcinoma 14,15 .…”

A Clinical Study of 130 Patients with Biliary Tract Cancers and Periampullary Tumors

“…The high incidence of bile duct carcinoma in this area has been attributed to infestation with liver flukes, such as Clonorchis sinensis in Hong Kong and Canton, and both Opisthorchis viverrini and Opisthorchis felineus in Bangkok [3,4], However, in Taiwan and Japan, where liver fluke infestation is uncommon, hepatolithiasis has been sug-KARGER E-Mail karger@kargcr.ch F a x + 41 61 306 12 34 http:// www. karger, ch gested to be the causal factor [5][6][7][8], Hepatolithiasis is a major disease in Asia, but again an uncommon disease in western countries [9], As reported in a retrospective study conducted in Taiwan, Hong Kong, Singapore and Japan, the relative percentage of hepatolithiasis as a proportion of all gallstone cases was highest in Taiwan at 53.5%, while the incidence in Hong Kong, Singapore and Japan was 3.1, 1.7 and 4.7%, respectively [10], The prevalence rate for Taiwan was adjusted to 20% after a nation-wide cooperative study [11], but the 20% relative prevalence rate is still the highest among Asian countries. The exact frequency of cholangiocarcinoma in association with he patolithiasis is not well known, although the reported inci dence ranges from 5.0%, based on operative findings [6], to 10.0%, based on autopsy findings [12].…”