Cholangiocarcinoma: clinical significance of tumor location along the extrahepatic bile duct.

Alden, Mark; Waterman, Frank M.; Topham, Allan; Barbot, Donna J.; Shapiro, Marvin J.; Mohiuddin, Mohammed

doi:10.1148/radiology.197.2.7480704

Cited by 38 publications

(24 citation statements)

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“…Polypoid cholangiocarcinoma is infrequently found in both the intra-and extrahepatic ducts. Histologically, this tumor is mostly of the papillary adenocarcinoma type, which shows intraluminal growth (2,56,63). This type of cholangiocarcinoma has a better prognosis than other types of cholangiocarcinoma.…”

Section: Cholangiocarcinomamentioning

confidence: 99%

Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis

et al. 2004

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Despite a gradual decrease in prevalence, clonorchiasis is still prevalent in East Asia. A large and compelling body of evidence links clonorchiasis and cholangiocarcinoma, although the mechanisms involved are not completely understood. Clonorchiasis induces biliary epithelial hyperplasia and metaplasia, and this could facilitate at least one stage of the carcinogenesis, which is promoting effect. In areas of endemic infection, more clonorchiasis cases are now diagnosed incidentally during radiological examinations such as cholangiography, ultrasonography, and computed tomography. Radiological findings are regarded as pathognomonic for clonorchiasis since they reflect the unique pathological changes of this disorder. These radiological examinations currently play important roles in the diagnosis, staging, and decision-making process involved in the treatment of cholangiocarcinoma. The morphological features and radiological findings of clonorchiasis-associated cholangiocarcinoma are essentially combinations of the findings for the two diseases. The morphological features of clonorchiasis- associated cholangiocarcinoma, observed in radiological examinations, do not differ from those of the usual cholangiocarcinoma. In patients diagnosed with or suspected to have clonorchiasis, radiological findings should be carefully scrutinized for occult cholangiocarcinoma

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Section: Cholangiocarcinomamentioning

confidence: 99%

Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis

et al. 2004

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“…2 Therefore, radiation therapy has been recommended as an adjuvant therapy. 10 Many reports suggest that postoperative radiation therapy improves the outcome of patients with unresected, positive microscopic margins; [11][12][13][14][15][16][17] however, the patients in these reports who received radiation therapy were compared with patients who had unresectable tumors, poor performance status, or metastatic disease. Therefore, it is important to establish the benefits of postoperative radiotherapy in a well-designed objective study.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Radiation Therapy After Surgery for Hilar Cholangiocarcinoma

et al. 2005

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“…However, a role for such adjuvant therapy has not been defined for patients with distal bile duct cancer, again because of the small experience with these patients. Although one previous study [21]claimed no benefit of adjuvant therapy compared to resection alone, this lack of benefit may have been related to a more advanced stage of disease and the presence of residual disease in that study. No firm conclusions can be drawn from our study since only 6 of the 15 patients were treated with adjuvant chemoradiation.…”

Section: Discussionmentioning

confidence: 68%

Adenocarcinoma of the Distal Bile Duct

et al. 2000

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Background/Aims: Primary distal bile duct adenocarcinomas (DBDAs) are unusual neoplasms, necessitating pancreaticoduodenectomy for cure. The aims of this study were to evaluate the prognostic importance of lymphatic and perineural invasion, long-term outcome of patients after resection, and differences in outcome with hilar cholangiocarcinoma and pancreatic carcinoma. Methods: The medical records and histopathological slides of 15 patients (8 men and 7 women) with documented DBDA after curative pancreaticoduodenectomy were reviewed. Results: Nine standard and 6 pylorus-preserving pancreaticoduodenectomies were performed. TNM staging included 1, 3, 2, 8, and 1 patient in stages I, II, III, and IVA and IVB, respectively. Lymphatic and perineural invasion was present in 4 (27%) and 9 (60%) patients, respectively. With multivariate analysis only serum bilirubin was a significant prognostic factor. Median survival was 21 months, and 2- and 5-year actuarial survivals were 40 and 20%, respectively. Median survival with adjuvant therapy (n = 6) was 21 months, with 5-year survival of 33%. Five-year actuarial survivals when lymphatic or perineural invasion was present were 0 and 11%, respectively. Conclusion: DBDA is aggressive, but entails a better prognosis than pancreatic ductal or more proximal bile duct carcinoma. Lymphatic and/or perineural invasion worsen survival.

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Cholangiocarcinoma: clinical significance of tumor location along the extrahepatic bile duct.

Abstract: Patients with proximal cancer should undergo primary RT, and expectations should be limited. Patients with distal cancer should undergo resection, and RT may not be needed.

Cited by 38 publications

References 0 publications

Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis

Clonorchiasis and Cholangiocarcinoma: Etiologic Relationship and Imaging Diagnosis

Effectiveness of Radiation Therapy After Surgery for Hilar Cholangiocarcinoma

Adenocarcinoma of the Distal Bile Duct

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