Cholangiocarcinoma: An-eight-year Experience in a Tertiary-Center in Iran

Mohammadalizadeh, A H; Ghobakhlou, Mehdi; Shalmani, Hamid Mohaghegh; Zali, Mohammad Reza

doi:10.7314/apjcp.2012.13.11.5381

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…In our study, the male to female ratio in the 16 CCA patients was 1.3. Mohammad-Alizadeh et al estimated that this ratio was 1.7 (180 males and 103 females) in 283 Iranian CCA patients ( 4 ). Therefore, in people from Iran, CCA is more common in males, which is partly because PSC (the major risk factor for CCA) affects men more than women ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…People with PSC are at high risk of developing cholangiocarcinoma (CCA), the reported incidence of which varies across different areas of the world ( 2 ). As there is no effective medical treatment for PSC, and liver transplantation (LT) results have been excellent, LT remains the optimum treatment choice for PSC patients with end-stage liver disease ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

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Cholangiocarcinoma Secondary to Primary Sclerosing Cholangitis in Explanted Livers: A Single-Center Study in the South of Iran

et al. 2015

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Background:Primary sclerosing cholangitis (PSC) is a chronic disease, characterized by chronic inflammation and fibrosis of bile duct epithelial cells. This is a significant contributory factor to the development of malignancy, most commonly cholangiocarcinoma (CCA), which is the second most common malignant liver tumor.Objectives:For the first time in Iran, we intend to describe our experience with cases of PSC, with and without CCA, in explanted livers, and compare our results with those found in other areas of the world.Patients and Methods:The study population comprised 181 individuals with a diagnosis of PSC who had undergone liver transplantation in the main liver transplant center of Iran, the largest center of hepatobiliary surgery in the south of that country, over a 3-year period between 2012 and 2014. All explanted livers, with and without CCA, were evaluated.Results:Of the 181 patients, 16 were found to have CCA, two of whom had been diagnosed after pathologic study of the explanted livers. Therefore it appeared that 8.8% of the patients with PSC in our center had developed CCA before liver transplantation.Conclusions:A comparison of our results with those obtained from other centers in both Western and Asian countries (which reported CCA in 3.6% - 36.5% of patients with PSC), shows that the incidence of CCA in the patients we studied is intermediate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cholangiocarcinoma Secondary to Primary Sclerosing Cholangitis in Explanted Livers: A Single-Center Study in the South of Iran

et al. 2015

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“…Primary liver cancer (PLC) primarily occurs in parenchymal hepatic cell or bile duct cell carcinomas and includes hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and cHCC-CC (Dai et al, 2013;Liu et al, 2013;Xu et al, 2013;Al-Bahrani et al, 2015). Of all, CC is a kind of PLC of primary intrahepatic biliary epithelial cells and its overall incidence accounts for 10% of PLC, with the increasing morbidity and mortality year by year (Mohammad-Alizadeh et al, 2012). In America, the morbidity of CC in the period of 1995~1999 increased by 165% compared with the period of 1975~1979, especially the morbidity of extrahepatic cholangiocarcinoma increased year after year in the period of 1992~2007 (Tyson et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Application of Joint Detection of AFP, CA19-9, CA125 and CEA in Identification and Diagnosis of Cholangiocarcinoma

Li²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the application of joint detection of serum AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma (CC). Materials and Methods: The levels of serum AFP, CA19-9, CA125 and CEA of both 30 patients with CC and 30 patients with hepatocellular carcinoma (HCC) were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic effects of single and joint detection of those 4 kinds of tumor markers for CC. Results: The levels of serum CA19-9, CA125 and CEA in CC patients were higher than that in HCC patients,whereas that of serum AFP was significantly lower s. The area under ROC curve of single detection of serum AFP, CA19-9, CA125 and CEA were 0.05, 0.86, 0.84 and 0.83, with the optimal cutoff values of 15.4 ng/ml, 125.1 U/ml, 95.7 U/ml and 25.9 ng/ml, correspondingly, and the percentage correct single diagnosis was <79%. With joint detection, the diagnostic effect of combined AFP, CA19-9, CA125 and CEA was the highest, with an area under the ROC curve of 0.94 (95%CI 0.88~0.99). Conclusions: Single detection of serum CA19-9, CA125 and EA is not meaningful. The sensitivity, specificity, the rate of correct diagnosis and the area under ROC curve of joint detection of AFP, CA19-9, CA125 and CEA are highest, indicating that the joint detection of these 4 tumor markers is of great importance in the diagnosis of CC.

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“…75 Symptoms commonly presented are painless jaundice (190, 66.9%), abdominal pain (77, 27%), and pruritus 133 (46.8%) and weight loss (169, 59.5%). 76 Although iCCAs, emerging above the second-order bile ducts, is the least common form of cholangiocarcinoma, it is considered the second most prevalent hepatic malignancy after HCC, representing approximately 10-15% of LC cases, with incidence and mortality rates of 0.3-6 and 1-6 per 100,000 per year respectively. CCA mortality, like all gastrointestinal cancers, is higher in men than in women around the world, and in Asian countries than Western countries.…”

Section: Cholangiocarcinoma (Cca)mentioning

confidence: 99%

“…75 Symptoms commonly presented are painless jaundice (190, 66.9%), abdominal pain (77, 27%), and pruritus 133 (46.8%) and weight loss (169, 59.5%). 76 …”

Section: Cholangiocarcinoma (Cca)mentioning

confidence: 99%

Gastrointestinal and Pancratohepatobiliary Cancers: A Comprehensive Review on Epidemiology and Risk Factors Worldwide

Hormati

Hajrezaei

Jazi

et al. 2022

Middle East J Dig Dis

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A significant number of cancer cases are afflicted by gastrointestinal cancers annually. Lifestyle and nutrition have a huge effect on gastrointestinal function, and unhealthy habits have become quite widespread in recent decades, culminating in the rapid growth of gastrointestinal cancers. The most prevalent cancers are lip and mouth cancer, esophageal cancer, gastric cancer, liver and bile duct cancer, pancreatic cancer, and colorectal cancer. Risk factors such as red meat consumption, alcohol consumption, tea, rice, viruses such as Helicobacter pylori and Ebstein Bar Virus (EBV), along with reduced physical activity, predispose the gastrointestinal tract to damage and cause cancer. According to the rapid increase of cancer incidence and late diagnosis of gastrointestinal malignancies, further epidemiological researches remain necessary in order to make appropriate population-based preventive policies. In this study, we reviewed clinical symptoms, risk factors, preventative measures, as well as incidence and mortality rates of gastrointestinal malignancies worldwide with focus on Iranian population.

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Cholangiocarcinoma: An-eight-year Experience in a Tertiary-Center in Iran

Cited by 6 publications

References 20 publications

Cholangiocarcinoma Secondary to Primary Sclerosing Cholangitis in Explanted Livers: A Single-Center Study in the South of Iran

Cholangiocarcinoma Secondary to Primary Sclerosing Cholangitis in Explanted Livers: A Single-Center Study in the South of Iran

Application of Joint Detection of AFP, CA19-9, CA125 and CEA in Identification and Diagnosis of Cholangiocarcinoma

Gastrointestinal and Pancratohepatobiliary Cancers: A Comprehensive Review on Epidemiology and Risk Factors Worldwide

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