Chokeberry (Aronia melanocarpa) fruit extract abrogates melanoma progression through boosting up IFN-γ-producing cells

Gajić, Dragica; Stojanović, Ivana; Koprivica, Ivan; Pejnović, Nada; Šavikin, Katarina; Ćujić-Nikolić, Nada; Saksida, Tamara

doi:10.1016/j.jff.2022.105185

Cited by 4 publications

(2 citation statements)

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“…High levels of quercetin derivatives and chlorogenic acid, in addition to the presence of different phenolic components, have been reported in the leaves of these two species [15][16][17][18][19][20]. Accordingly, a few studies pointed out that chokeberry leaves possess different biological activities, such as antioxidant, antineurodegenerative, hypoglycemic, and anticancer activity [21][22][23][24]. Likewise, antibacterial, anti-inflammatory, antioxidant, and blood glucose-and lipid-lowering effects have been detected in Vaccinium genus leaves [18,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Microencapsulated Bilberry and Chokeberry Leaf Extracts with Potential Health Benefits

Kuzmanović Nedeljković,

Radan,

Ćujić Nikolić

et al. 2023

Plants

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The aim of the research was to develop microencapsulated powders of bilberry and chokeberry extracts via the spray drying technique. Two biopolymers, pectin alone and in combination with HP-β-CD, were used to preserve the antioxidant, hypoglycemic, photoprotective, and antimicrobial bioactivity of the berry leaf extracts. Moreover, the formed powders were characterized in terms of technological, chemical, and several biological properties. The obtained micro-sized powders (mean average particle diameter from 3.83 to 5.94 µm) demonstrated a process yield of up to 73%. The added biopolymers improved the flowability and cohesive properties of the powders and increased their thermal stability to 170 °C. The total content of polyphenolics in the powders ranged from 323.35 to 367.76 mg GAE/g DW for bilberry and from 186.85 to 227.59 mg GAE/g DW for chokeberry powders; meanwhile, chlorogenic acid was the predominant compound in powders. All samples showed stronger α-glucosidase inhibitory activity (IC50 values ranged from 5.00 to 19.59 µg/mL) compared with the reference standard. The study confirmed that spray drying is a suitable method for the preservation of the polyphenolic-rich extracts, while the addition of carriers has a positive effect on the improvement of microencapsulated powders’ properties.

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Section: Introductionmentioning

confidence: 99%

Microencapsulated Bilberry and Chokeberry Leaf Extracts with Potential Health Benefits

Kuzmanović Nedeljković,

Radan,

Ćujić Nikolić

et al. 2023

Plants

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“…Mouse melanoma cells (B16-F10) were cultured in RPMI-1640 medium supplemented with 1% penicillin–streptomycin mixture and 10% fetal bovine serum (FBS) ( Gajić et al, 2022 ). The cells were placed in a 96-well plate at a density of 1 × 10 5 cells/ml and left to incubate for 24 h. After discarding the supernatant, different concentrations of Cassia seed fermentation solution were added.…”

Section: Methodsmentioning

confidence: 99%

Mitigation of oxidative stress and inflammatory factors, along with the antibrowning and antimicrobial effects of cassia seed microbial fermentation solution

Xie,

Gu,

Chen

et al. 2024

Front. Microbiol.

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IntroductionCassia seeds, originating from the mature seeds of leguminous cassia species, possess pharmacological effects attributed to their rich composition of various active ingredients, notably anthraquinones. While current research predominantly focuses on pharmaceutical extractions, there has been limited progress in fermentation studies.MethodsOur study aimed to enhance the content of active compounds such as anthraquinones, flavonoids, and polyphenols using microbial fermentation techniques. We specifically optimized a fermentation system through a single-factor experimental design.ResultsThe antioxidant properties of the fermentation solution were validated through assays involving HaCaT cells and zebrafish. We observed effective suppression of inflammatory reactions in both RAW264.7 cells and transgenic zebrafish by the fermentation solution. Moreover, significant inhibition of tyrosinase activity and melanin production was evident in B16-F10 cells and zebrafish. Positive outcomes were also obtained in antibacterial assays and chick embryo experiments.DiscussionThese findings highlight the potential of cassia seed fermentation solution as a safe and eco-friendly material in food chemistry and biomedical sciences.

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From the chokeberry fruit products and by-products to health-promoting effects through multifaceted in vitro bioactivity evaluation and molecular docking studies

Milutinović,

Ćujić Nikolić,

Radan

et al. 2024

JBR

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BACKGROUND: Polyphenolic-rich chokeberry extracts and juice could provide health benefits in humans. Moreover, by-products after processing stand out as a potential new source of valuable compounds. OBJECTIVE: The research aimed to evaluate in vitro bioactivity of chokeberry fruit extract, juice, and waste extract (material remaining after juice processing) based on their chemical composition and molecular docking analysis. METHODS: Spectrophotometric methods were used to determine the phenolics, anthocyanins, flavonoids, and proanthocyanins content in freeze-dried samples. Additionally, individual anthocyanins, flavonoids, and sugars were identified through HPLC analysis. The antioxidant capacity was tested using two in vitro methods and assessing antimicrobial activity. The effects of tyrosinase and acetylcholinesterase inhibition were examined using spectrophotometric methods. Molecular docking analysis identified the interaction of chokeberry components with the active sites of these enzymes. RESULTS: The waste extract exhibited the most robust antioxidant activity within the DPPH system. While bactericidal activity was absent across all chokeberry preparations, they demonstrated inhibitory effects on specific microbiological strains relevant to the gastrointestinal tract. Results revealed the chokeberry products’ ability to inhibit tyrosinase and acetylcholinesterase. Molecular docking confirmed the strong interactions between chokeberry compounds and these enzymes. CONCLUSION: The results indicate the potential of chokeberry products and by-products as valuable resources for pharmaceutical applications.

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Chokeberry (Aronia melanocarpa) fruit extract abrogates melanoma progression through boosting up IFN-γ-producing cells

Cited by 4 publications

References 44 publications

Microencapsulated Bilberry and Chokeberry Leaf Extracts with Potential Health Benefits

Microencapsulated Bilberry and Chokeberry Leaf Extracts with Potential Health Benefits

Mitigation of oxidative stress and inflammatory factors, along with the antibrowning and antimicrobial effects of cassia seed microbial fermentation solution

From the chokeberry fruit products and by-products to health-promoting effects through multifaceted in vitro bioactivity evaluation and molecular docking studies

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