Choices of therapy for exercise-induced asthma in children

Price, John

doi:10.1034/j.1398-9995.2001.00003.x

Cited by 20 publications

(14 citation statements)

References 37 publications

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“…It is well known that oral administration of a soluble protein antigen induces a marked reduction in T-cell proliferative responses and antibody responses after a systemic challenge [8, 9]. However, in this study, oral administration of OVA-liposome conjugates did not affect T-cell cytokine production, nor did it inhibit anti-OVA IgG antibody production induced by immunization with OVA-alum.…”

Section: Discussioncontrasting

confidence: 48%

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Selective Inhibition of Systemic Anti-OVA IgE Production in Response to Oral Pre-Treatment with OVA-Liposome Conjugates

Naito¹,

Taneichi²,

Katô³

et al. 2002

Int Arch Allergy Immunol

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Background: We have previously reported that intraperitoneal injection with OVA-liposome conjugates induces OVA-specific and IgE-selective unresponsiveness in mice. Methods: In the present study, the effects of oral pre-treatment with OVA-liposome conjugates or with plain OVA solution on anti-OVA IgG antibody production were investigated in mice after subsequent immunization with alum-adsorbed OVA. Control mice received only the immunization. Results: The levels of serum anti-OVA IgG antibody in mice receiving oral administration of OVA-liposome were comparable to those in the control mice. However, in mice receiving oral administration of the same dose of plain OVA, levels of serum anti-OVA IgG antibody were significantly lower than those in control mice. Surprisingly, anti-OVA IgE antibody production was completely inhibited in mice receiving oral administration of OVA-liposome conjugates. Splenic CD4⁺ T cells of mice receiving oral administration of OVA-liposome and those of control mice produced comparable levels of cytokines, while those of mice receiving oral administration of plain OVA solution produced significantly lower levels of cytokines than those in the other two groups. Conclusion: Orally administered OVA-liposome did not affect anti-OVA IgG production but did inhibit anti-OVA IgE antibody production, while orally administered OVA solution inhibited production of both IgG and IgE antibodies. These results suggest that antigen-liposome conjugates can possibly be orally administered in order to control antigen-specific IgE antibody production, without affecting IgG antibody production.

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Section: Discussioncontrasting

confidence: 48%

“…The mucosal immune apparatus may thus provide an alternative and also a less expensive approach to vaccination. However, numerous attempts to administer foreign substances to mucosal membranes, predominantly by the oral route, have resulted in the induction of immune unresponsiveness due to what is referred to as oral tolerance [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Selective Inhibition of Systemic Anti-OVA IgE Production in Response to Oral Pre-Treatment with OVA-Liposome Conjugates

Naito¹,

Taneichi²,

Katô³

et al. 2002

Int Arch Allergy Immunol

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“…Children with exercise-induced asthma do not show a long-term increase in airway reactivity [35]. It seems logical to provide prophylactic treatment that will facilitate participation in normal childhood games and activities.…”

Section: Discussionmentioning

confidence: 99%

Are inhaled corticosteroids associated with an increased risk of fracture in children?

et al. 2004

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Inhaled corticosteroids are widely used in the long-term management of asthma in children. Data on the relationship between inhaled corticosteroid therapy and osteoporotic fracture are inconsistent. We address this issue in a large population-based cohort of children aged 4-17 years in the UK (the General Practice Research Database). The incidence rates of fracture among children aged 4-17 years taking inhaled corticosteroids (n=97,387), taking bronchodilators only (n=70 984) and a reference group (n=345,758) were estimated. Each child with a non-vertebral fracture (n=23,984) was subsequently matched by age, sex, practice, and calendar time to one child without a fracture. Fracture incidence was increased in children using inhaled corticosteroids, as well as in those receiving bronchodilators alone. With an average daily beclomethasone dose of 200 lg or less, the crude fracture risk relative to nonusers was 1.10 [95% confidence interval (CI), 0.96-1.26]; with dosage of 201-400 lg, it was 1.23 (95% CI, 1.08-1.39); and with dosages over 400 lg, it was 1.36 (95% CI, 1.11-1.67). This excess risk disappeared after adjustment for indicators of asthma severity. The increased risk of fracture associated with use of inhaled corticosteroids is likely to be the result of the underlying illness, rather than being directly attributable to inhaled corticosteroid therapy.

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“…According to the ATS guidelines, EIB is defined by a drop of ≥10% in Forced Expiratory Volume in one second (FEV 1 ) after exertion on an exercise test 6. The prevalence of EIB in children with asthma ranges from 40% to 90% 4 7 8. There is an ongoing debate about the mechanism whereby physical exercise can provoke EIB in asthma.…”

Section: Introductionmentioning

confidence: 99%

Exercise training in children with asthma: a systematic review

et al. 2013

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Exercise can provoke asthma symptoms, such as dyspnoea, in children with asthma. Exercise-induced bronchoconstriction (EIB) is prevalent in 40-90% of children with asthma. Conversely, exercise can improve physical fitness. The purpose of this paper is to provide a systematic review of the literature regarding the effects of exercise training in children with asthma, particularly in relation to: EIB, asthma control, pulmonary function, cardiorespiratory parameters and parameters of underlying pathophysiology. A systematic search in several databases was performed. Controlled trials that undertook a physical training programme in children with asthma (aged 6-18 years) were selected. Twenty-nine studies were included. Training had positive effects on several cardiorespiratory fitness parameters. A few studies demonstrated that training could improve EIB, especially in cases where there was sufficient room for improvement. Peak expiratory flow was the only lung function parameter that could be improved substantially by training. The effects of training on asthma control, airway inflammation and bronchial hyper-responsiveness were barely studied. Owing to the overall beneficial effects of training and the lack of negative effects, it can be concluded that physical exercise is safe and can be recommended in children with asthma. A training programme should have a minimum duration of 3 months, with at least two 60 min training sessions per week, and a training intensity set at the (personalised) ventilatory threshold. Further research is recommended regarding the effects of exercise on underlying pathophysiological mechanisms and asthma control in children with asthma.

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Choices of therapy for exercise-induced asthma in children

Cited by 20 publications

References 37 publications

Selective Inhibition of Systemic Anti-OVA IgE Production in Response to Oral Pre-Treatment with OVA-Liposome Conjugates

Selective Inhibition of Systemic Anti-OVA IgE Production in Response to Oral Pre-Treatment with OVA-Liposome Conjugates

Are inhaled corticosteroids associated with an increased risk of fracture in children?

Exercise training in children with asthma: a systematic review

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