Choice selection and reward anticipation: an fMRI study

Ernst, Monique; Nelson, Eric E.; McClure, Erin B.; Monk, Christopher S.; Munson, Suzanne; Eshel, Neir; Zarahn, Eric; Leibenluft, Ellen; Zametkin, Alan J.; Towbin, Kenneth E.; Blair, James; Charney, Dennis S.; Pine, Daniel S.

doi:10.1016/j.neuropsychologia.2004.05.011

Cited by 334 publications

(305 citation statements)

References 66 publications

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“…As S− cues are not rewarded, the signal obtained for those responses cannot be driven by the reward itself, making a reward expectation account a plausible alternative. Our findings are consistent with several human neuroimaging studies showing an activation of the NAc during the anticipatory phase of a monetary incentive delay task (Ernst et al, 2004;Kirsch et al, 2003;Knutson et al, 2000). A straightforward acceptance of the reward anticipation account is somewhat challenged by the lack of significant increase in NAc O 2 signal following incorrect lever choice to the S+.…”

Section: Nucleus Accumbens Activation and Reward Anticipationsupporting

confidence: 90%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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a b s t r a c t a r t i c l e i n f oReal-time in vivo oxygen amperometry, a technique that allows measurement of regional brain tissue oxygen (O 2 ) has been previously shown to bear relationship to the BOLD signal measured with functional magnetic resonance imaging (fMRI) protocols. In the present study, O 2 amperometry was applied to the study of reward processing in the rat nucleus accumbens to validate the technique with a behavioural process known to cause robust signals in human neuroimaging studies. After acquisition of a cued-lever pressing task a robust increase in O 2 tissue levels was observed in the nucleus accumbens specifically following a correct lever press to the rewarded cue. This O 2 signal was modulated by cue reversal but not lever reversal, by differences in reward magnitudes and by the motivational state of the animal consistent with previous reports of the role of the nucleus accumbens in both the anticipation and representation of reward value. Moreover, this modulation by reward value was related more to the expected incentive value rather than the hedonic value of reward, also consistent with previous reports of accumbens coding of "wanting" of reward. Altogether, these results show striking similarities to those obtained in human fMRI studies suggesting the use of oxygen amperometry as a valid surrogate for fMRI in animals performing cognitive tasks, and a powerful approach to bridge between different techniques of measurement of brain function.

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Section: Nucleus Accumbens Activation and Reward Anticipationsupporting

confidence: 90%

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

et al. 2012

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“…For example, McClure et al (2004) have shown that decisions reflecting a preference for smaller immediate rewards over larger delayed rewards are associated with relatively increased activation of the ventral striatum, orbitofrontal cortex, and medial prefrontal cortex, all regions linked to the socio-emotional network, whereas regions implicated in cognitive control (dorsolateral prefrontal cortex, parietal areas) are engaged equivalently across decision conditions. Similarly, two recent studies (Matthews et al, 2004;Ernst et al, 2004) show that increased activity in regions of the socio-emotional network (ventral striatum, medial prefrontal cortex) predicts the selection of comparatively risky (but potentially highly rewarding) choices over more conservative choices. Finally, one recent experimental study found that transient disruption of right dorsolateral prefrontal cortical function via transcranial magnetic stimulation (i.e., disruption of a region known to be crucial to cognitive control) increased risktaking in a gambling task (Knoch, Gianotti, Pascual-Leone, Treyer, Regard, Hohmann, et al, 2006).…”

Section: Functional Changes In the Cognitive Control Systemmentioning

confidence: 75%

“…This competitive interaction has been implicated in a wide range of decision making-contexts, including drug use (Bechara, 2005;Chambers, 2003), social decision processing (Sanfey et al, 2003), moral judgments (Greene et al, 2004), and the valuation of alternative rewards and costs Ernst et al, 2004), as well as in an account of adolescent risktaking (Chambers, 2003). In each instance, impulsive or risky choices are presumed to arise when the socio-emotional network dominates the cognitive control network.…”

Section: Functional Changes In the Cognitive Control Systemmentioning

confidence: 99%

A social neuroscience perspective on adolescent risk-taking

Steinberg¹

2008

Developmental Review

2,716

2,024

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This article proposes a framework for theory and research on risk-taking that is informed by developmental neuroscience. Two fundamental questions motivate this review. First, why does risktaking increase between childhood and adolescence? Second, why does risk-taking decline between adolescence and adulthood? Risk-taking increases between childhood and adolescence as a result of changes around the time of puberty in the brain's socio-emotional system leading to increased rewardseeking, especially in the presence of peers, fueled mainly by a dramatic remodeling of the brain's dopaminergic system. Risk-taking declines between adolescence and adulthood because of changes in the brain's cognitive control system -changes which improve individuals' capacity for selfregulation. These changes occur across adolescence and young adulthood and are seen in structural and functional changes within the prefrontal cortex and its connections to other brain regions. The differing timetables of these changes make mid-adolescence a time of heightened vulnerability to risky and reckless behavior.

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“…These stimuli include food and sexual behavior (given that sustenance and procreation are crucial for the survival of a species [95,96]), and social interactions with conspecifics [39,97]. Nonclinical human neuroimaging studies indicate that the mesolimbic DA response to primary rewards may operate similarly in humans in response to more abstract, or secondary, rewards such as monetary incentives [98-100]. Recent evidence suggests a common ‘neural currency’ for coding monetary and primary (for example, food) rewards [101].…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

243

198

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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Choice selection and reward anticipation: an fMRI study

Cited by 334 publications

References 66 publications

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

Changes in reward-related signals in the rat nucleus accumbens measured by in vivo oxygen amperometry are consistent with fMRI BOLD responses in man

A social neuroscience perspective on adolescent risk-taking

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

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