Choice of vasoconstrictors for children with rhinosinusitis

Гаращенко, Т. И.; Бойкова, Н. Э.; Zelenkin, E M

doi:10.21508/1027-4065-2016-61-3-124-131

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…Immaturity of the cavernous tissue in the nasal turbinates can also be the cause of intoxication. The inferior nasal meatus becomes the main conductor of the air flow only after the age of 7 (Garashchenko et al 2016). Another cause of acute poisoning in children is the narrow therapeutic window of the drug, a small interval between the average therapeutic and the toxic doses (Radtsig et al 2012;Garashchenko et al 2016;Kunelskaya et al 2017;Kuzminov et al 2018).…”

Section: Main Causes Of Acute Poisoning In Young Childrenmentioning

confidence: 99%

Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

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Introduction: Acute poisoning by nasal decongestants is an important issue in pediatrics due to physiological and anatomical characteristics of the child’s body and pharmacokinetics of drugs in early childhood. Epidemiology: The number of poisonings by this group of drugs ranged from 4% to 39% during the period from 2000 to 2018. All the studies reported that the most severe degree of intoxication was observed in children aged 1–3 years. Mechanism of action of nasal decongestants: The peculiarity of selective alpha2-adrenergic agonists is that when taken orally, misused or overdosed, they lose their selectivity for the target receptor. As a result, the drug causes acute poisoning and most often this effect occurs in children and adolescents. Clinical features and diagnostic criteria: Clinical signs of acute poisoning can appear both as a result of an overdose of the nasal decongestants and due to a therapeutic use of the drug according to the instruction. The symptoms are manifested by hypothermia, skin pallor, bradycardia, arterial hypotension, profuse sweating, and acrocyanosis. Imidazoline receptors and new opportunities: It is assumed that toxic effect of topical decongestants occurs not only by activation of alpha2-adrenergic receptors, but also through their influence on the selective imidazoline receptors. Based on the structure of these drugs, it is assumed that imidazoline receptors are the primary binding site for these drugs. Conclusion: Understanding the described mechanisms of alpha2-adrenergic agonist action and peculiarities of the child’s symptoms in acute poisoning is necessary for the timely diagnosis and selection of the correct treatment strategy.

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Section: Main Causes Of Acute Poisoning In Young Childrenmentioning

confidence: 99%

Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

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Acute poisoning in children: Etiology, structure, treatment tactics and outcomes

Karpushkina¹,

Zhdanova²,

Batisheva³

2022

RRP

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Introduction: Acute poisoning is often observed in children and can have serious consequences since it is characterized by rapid development of symptoms and obvious disfunction of vital organs. Materials and methods: Retrospective analysis of the case histories of the children with acute poisoning admitted to Voronezh Regional Children’s Clinical Hospital No. 1 in 2016–2019 was carried out. Anamnesis, clinical and laboratory studies and effective treatment criteria were entered into electronic spreadsheets and served as the basis for a database on children’s poisoning. Results and discussion: Analysis of 183 case histories of children with intoxication aged 4 months to 17 years old was performed. Distribution per age showed bimodal peaks at 1–2 years and 13–14 years. Poisoning was accidental in 96.2% of the cases, and 3.8% of the adolescents reported suicide cases. In the group of young children, acute drug poisoning is more frequent in girls (P < 0.05). In the older groups, there is no gender difference in frequency of poisoning cases. Early call for medical help is typical for the adolescent age group. Correlation between time of help-seeking and children’s age is statistically significant (correlation coefficient r = 0.38, P < 0.05). Conclusion: Study of poisoning issue in children will allow to carry out targeted preventive measures to reduce the number of poisoning cases, prevent their consequences and to determine the most rational modus operandi for medical personnel for effective and safe pharmacotherapy. Graphical abstract In pediatric practice, intoxication by poisons and drugs is among the most common reasons for seeking medical help and hospitalization in intensive care units. It is important to study and record dynamics, structure and frequency of acute poisoning with subsequent development of prevention and treatment methods.

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Choice of vasoconstrictors for children with rhinosinusitis

Cited by 2 publications

References 3 publications

Pathogenetic features of acute naphazoline poisoning in children

Pathogenetic features of acute naphazoline poisoning in children

Acute poisoning in children: Etiology, structure, treatment tactics and outcomes

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