Abstract. The low Mach number limit for classical solutions to the full Navier Stokes equations is here studied. The combined effects of large temperature variations and thermal conduction are accounted. In particular we consider general initial data. The equations lead to a singular problem, depending on a small scaling parameter, whose linearized is not uniformly well-posed. Yet, it is proved that the solutions exist and are uniformly bounded for a time interval which is independent of the Mach number Ma ∈ (0, 1] , the Reynolds number Re ∈ [1, +∞] and the Péclet number Pe ∈ [1, +∞] . Based on uniform estimates in Sobolev spaces, and using a Theorem of G. Métivier and S. Schochet [31], we next prove that the penalized terms converge strongly to zero. It allows us to rigorously justify, at least in the whole space case, the well-known computations given in the introduction of the P.-L. Lions' book [26].