Choice of LECS Procedure for Benign and Malignant Gastric Tumors

Min, Jae-Seok; Seo, Kyung Won; Jeong, Sang‐Ho

doi:10.5230/jgc.2021.21.e21

Cited by 11 publications

(8 citation statements)

References 52 publications

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“…Other techniques (Table 3 ) have been developed to avoid spread of the tumor to the peritoneum[ 37 - 39 ]. When performed by expert teams they show a lot of promise and achieve solid oncologic results[ 40 , 41 ].…”

Section: Treatmentmentioning

confidence: 99%

Early gastric cancer: A challenge in Western countries

Chiarello¹,

Fico²,

Pepe³

et al. 2022

WJG

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Early gastric cancer (EGC) is an invasive carcinoma involving only the stomach mucosa or submucosa, independently of lymph node status. EGC represents over 50% of cases in Japan and in South Korea, whereas it accounts only for approximately 20% of all newly diagnosed gastric cancers in Western countries. The main classification systems of EGC are the Vienna histopathologic classification and the Paris endoscopic classification of polypoid and non-polypoid lesions. A careful endoscopic assessment is fundamental to establish the best treatment of EGC. Generally, EGCs are curable if the lesion is completely removed by endoscopic resection or surgery. Some types of EGC can be resected endoscopically; for others the most appropriate treatment is surgical resection and D2 lymphadenectomy, especially in Western countries. The favorable oncological prognosis, the extended lymphadenectomy and the reconstruction of the intestinal continuity that excludes the duodenum make the prophylactic cholecystectomy mandatory to avoid the onset of biliary complications.

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Section: Treatmentmentioning

confidence: 99%

Early gastric cancer: A challenge in Western countries

Chiarello¹,

Fico²,

Pepe³

et al. 2022

WJG

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“…This may reflect the fact that large protruding tumors do not require LECS because LECS affords no advantages when used to treat large exophytic tumors. In other words, LECS would be a better option to treat small and endophytic duodenal tumors, as shown in other studies for gastric tumors [ 21 22 ].…”

Section: Discussionmentioning

confidence: 66%

Clinicopathological features and management strategy for superficial nonampullary duodenal tumors: a multi-center retrospective study

Kim

Lee

et al. 2022

Ann Surg Treat Res

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Purpose We investigated the clinicopathological features and management for superficial nonampullary duodenal tumors (SNADTs). The safety and feasibility of laparoscopic management, especially laparoscopic endoscopic cooperative surgery (LECS), were evaluated. Methods A total of 59 patients with SNADTs who underwent operations from January 2009 to December 2018 at all 8 institutions of the Catholic Medical Center were identified in our comprehensive multi-institutional database. Clinicopathological and surgical data on the 4 anatomical regions of the duodenum were collected and compared. Characteristics of conventional laparoscopic procedure (laparoscopy-only) and LECS procedures were also compared. Results There were significantly more asymptomatic patients with tumors in the first and second vs. third and fourth duodenal regions. Gastrointestinal stromal tumors (GISTs), carcinoids, and ectopic pancreatic tumors were identified in 32, 12, and 5 cases, respectively. Forty-two patients (71.2%) underwent laparoscopy. Of patients undergoing laparoscopy, the LECS group exhibited significantly more endophytic features and smaller tumor sizes (P < 0.001 and P < 0.001, respectively). Although no significant difference in the wedge resection or postoperative complication rate was seen between the 2 groups (P = 0.096 and P = 0.227, respectively), the wedge resection rate was higher, and the complication rate lower, in the LECS group than the conventional laparoscopic surgery group. Conclusion Most of the SNADTs located in proximal duodenum were detected incidentally. GISTs were the most common diagnoses of SNADTs in all locations. In treating these tumors, laparoscopic resection is safe and feasible. Especially, LECS may be ideal for treating small endophytic tumors, minimizing over-resection and postoperative complications.

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“…At present, endoscopic mucosal resection and endoscopic submucosal dissection are the preferred treatments in the early stages of GC ( Simić et al, 2019 ; Min et al, 2021 ). However, the disease progresses rapidly when patients are diagnosed with GC that are already beyond the early stages; so, the 5-year disease survival rates of GC patients remain low ( Li et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of an m6A Modification of JAK-STAT Signaling Pathway–Related Prognostic Prediction Model in Gastric Cancer

et al. 2022

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Background: Gastric cancer (GC) is one of the malignant tumors worldwide. Janus (JAK)–signal transduction and activator of transcription (STAT) signaling pathway is involved in cellular biological process and immune function. However, the association between them is still not systematically described. Therefore, in this study, we aimed to identify key genes involved in JAK-STAT signaling pathway and GC, as well as the potential mechanism.Methods: The Cancer Genome Atlas (TCGA) database was the source of RNA-sequencing data of GC patients. Gene Expression Omnibus (GEO) database was used as the validation set. The predictive value of the JAK-STAT signaling pathway-related prognostic prediction model was examined using least absolute shrinkage and selection operator (LASSO); survival, univariate, and multivariate Cox regression analyses; and receiver operating characteristic curve (ROC) analyses to examine the predictive value of the model. Quantitative real-time polymerase chain reaction (qRT-PCR) and chi-square test were used to verify the expression of genes in the model and assess the association between the genes and clinicopathological parameters of GC patients, respectively. Then, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), gene set enrichment analysis, version 3.0 (GSEA), sequence-based RNA adenosine methylation site predictor (SRAMP) online websites, and RNA immunoprecipitation (RIP) experiments were used to predict the model-related potential pathways, m6A modifications, and the association between model genes and m6A.Results: A four-gene prognostic model (GHR, PIM1, IFNA8, and IFNB1) was constructed, namely, riskScore. The Kaplan–Meier curves suggested that patients with high riskScore expression had a poorer prognosis than those with low riskScore expression (p = 0.006). Multivariate Cox regression analyses showed that the model could be an independent predictor (p < 0.001; HR = 3.342, 95%, CI = 1.834–6.088). The 5-year area under time-dependent ROC curve (AUC) reached 0.655. The training test set verified these results. Further analyses unveiled an enrichment of cancer-related pathways, m6A modifications, and the direct interaction between m6A and the four genes.Conclusion: This four-gene prognostic model could be applied to predict the prognosis of GC patients and might be a promising therapeutic target in GC.

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Choice of LECS Procedure for Benign and Malignant Gastric Tumors

Cited by 11 publications

References 52 publications

Early gastric cancer: A challenge in Western countries

Early gastric cancer: A challenge in Western countries

Clinicopathological features and management strategy for superficial nonampullary duodenal tumors: a multi-center retrospective study

Identification and Validation of an m6A Modification of JAK-STAT Signaling Pathway–Related Prognostic Prediction Model in Gastric Cancer

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