1957
DOI: 10.1111/j.1749-6632.1957.tb40776.x
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Choice of Anesthesia for Geriatric Patients

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1964
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“…The decline of the cardiovascular system (decreased cardiac reserve and regional blood flow, and increased circulation time) (19, 21, 24–27, 30, 38) may contribute to an altered and delayed distribution of the drug as well as a delay in its elimination. In the case of volatile general anesthetics, respiratory changes with age (7, 25–27, 29) greatly affect the induction and duration of anesthesia, and other alterations (cardiovascular and renal) affect the tolerance of the patient to the anesthetic (41, 42).…”
Section: Age‐related Changes Affecting Drug Activitymentioning
confidence: 99%
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“…The decline of the cardiovascular system (decreased cardiac reserve and regional blood flow, and increased circulation time) (19, 21, 24–27, 30, 38) may contribute to an altered and delayed distribution of the drug as well as a delay in its elimination. In the case of volatile general anesthetics, respiratory changes with age (7, 25–27, 29) greatly affect the induction and duration of anesthesia, and other alterations (cardiovascular and renal) affect the tolerance of the patient to the anesthetic (41, 42).…”
Section: Age‐related Changes Affecting Drug Activitymentioning
confidence: 99%
“…Because of the variability of the aging process and because we are limited for the most part to cross‐sectional comparisons, studies in man are dependent upon data obtained on large numbers of subjects; the extrapolation of average results to the individual is virtually impossible except to provide a basis for initiating a therapeutic regimen. With respect to drug therapy in geriatric patients, extreme caution should be used, and the therapeutic schedule should be based on the previous drug history of the patient and a thorough knowledge of the pharmacology of the drug in question (41, 48). Individualism is an absolute necessity (8, 49).…”
Section: Difficulties In the Study Of Age‐activity Relationshipsmentioning
confidence: 99%
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