Choanal atresia: Histochemical, immunohistochemical and ultrastructure study of the nasal mucosa

Elsheikh, Ezzeddin; El‐Anwar, Mohammad Waheed; Abdel-Aziz, Hesham R.; Mohamed, Anan Fatehy; Annany, Ahmad

doi:10.1016/j.ijporl.2014.11.035

Cited by 4 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elsheikh et al suggested that there was no major difference in mucosal volume in the atresia side for the main histological features. Despite the presence of general histological features, changes were determined in the tissue sample, including distorted cilia and a marked increase in mucosal secretion from the submucosal glands, associated with a marked reduction in goblet cell density and cellular lymphocytic infiltration [17].…”

Section: Discussionmentioning

confidence: 99%

The effects of choanal atresia on development of the paranasal sinuses and turbinates

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The effects of choanal atresia on development of the paranasal sinuses and turbinates

et al. 2017

View full text Add to dashboard Cite

show abstract

“…3 The choanal atresia side is also characterized by accumulated tenacious mucous secretion in the nasal cavity. 4 12 …”

Section: Discussionmentioning

confidence: 99%

“…The lack of mucous drainage could also be increased by the constricted glandular excretory ducts of the thick basal membrane that was detected in the nasal mucosa of the choanal atresia side. 4 …”

Section: Discussionmentioning

confidence: 99%

“…Then, the biopsies were subjected to histopathological, histochemical and immunohistochemical studies, as described by Elsheikh et al 4 …”

Section: Methodsmentioning

confidence: 99%

“…The main found histological features of the nasal mucosa in choanal atresia are distorted cilia, 3 4 marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. 3 This raised a question: are these found features permanent, and will these patients complain of thick mucus secretion for life?…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study

Elsheikh

El‐Anwar

Abdel-Aziz

2017

Int Arch Otorhinolaryngol

Self Cite

View full text Add to dashboard Cite

Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. Objective To study the nasal mucosal changes in cases of choanal atresia after successful repair compared with pre-repair mucosal histological features. Methods Tissue samples were taken from the inferior turbinate of 3 patients (1 bilateral and 2 unilateral) who were successfully operated. Then, the biopsies were subjected to histopathological, histochemical and immunohistochemical studies. After that, the results were compared with pre-repair findings in the choanal atresia side and in the normal side. Results Four biopsies (4 repaired choanal atresia sides) of the mucosa of the inferior turbinate revealed that 1 patient (who had a bilateral choanal atresia repaired), after achieving a patent choana for 8 months, had not completely recovered a normal nasal mucosa. The other 2 patients, after 18 and 23 months of achieving a patent choana, showed normal nasal cavities. Conclusion The main histological features of the nasal mucosa in choanal atresia could be reversed by surgery, making the patients regain their choanal patency, with their mucosae changing back to normal gradually with time.

show abstract

False Computed Tomography Findings in Bilateral Choanal Atresia

Elsheikh

El‐Anwar

2015

Int Arch Otorhinolaryngol

Self Cite

View full text Add to dashboard Cite

Introduction Choanal atresia (CA) is a challenging surgical problem defined as a failure in the development of communication between the nasal cavity and nasopharynx. Objective The objective of this study is to describe computed tomography (CT) findings in cases with bilateral choanal atresia. Methods The study involved performing axial and coronal non-contrast CT scanning with 2–3 mm sections on14 neonates that had bilateral CA. We used fiberoptic nasal endoscopy to confirm the diagnosis. We evaluated coronal CT to study the skull base area in such neonates. Results This study included 14 neonates with bilateral CA; with mean age of 7 ± 3.5 days. Mixed atretic plates were found in 12 (85.7%) cases while two (14.3%) had pure bony atresia. Isolated CA was detected in 9 cases (64.3%) and 5 (35.7%) cases had associated anomalies. Coronal CT showed soft tissue density in the nasal cavity that appeared to extend through an apparent defect in the nasal roof (cribriform plate), falsely diagnosed by radiologists as associated encephalocele. At the time of surgical repair, all patients showed thick tenacious mucous secretions in both nasal cavities and revealed no encephalocele. Nasal roof remained intact in all cases. Conclusion The thick secretion of bilateral CA could give a false encephalocele appearance on the CT. It is highly recommended to perform proper suction of the nasal cavity of suspected CA cases just before CT scanning.

show abstract

Choanal atresia: Histochemical, immunohistochemical and ultrastructure study of the nasal mucosa

Cited by 4 publications

References 10 publications

The effects of choanal atresia on development of the paranasal sinuses and turbinates

The effects of choanal atresia on development of the paranasal sinuses and turbinates

Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study

False Computed Tomography Findings in Bilateral Choanal Atresia

Contact Info

Product

Resources

About