Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway

Suriyo, Tawit; Tachachartvanich, Phum; Visitnonthachai, Daranee; Watcharasit, Piyajit; Satayavivad, Jutamaad

doi:10.1016/j.tox.2015.10.009

Cited by 27 publications

(13 citation statements)

References 52 publications

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“…EGFR is important oncogene that shown strong power of oncogenicity, by promotion of cell growth, migration, invasion and epithelial mesenchymal transition (EMT), as well as inhibition of cell apoptosis in many tumors including CRC [24, 29]. Thus, we next examined EGFR expression in human primary CRC and pair-matched adjacent colorectal tissues, and our western blot results demonstrated that EGFR protein was increased in CRC tissues compared with normal colorectal tissues (4.4-fold of increase) (Figure 2A).…”

Section: Resultsmentioning

confidence: 99%

“…Over-expression and activation of EGFR plays a positive role on cell growth and metastasis in variety of solid tumors including CRC [24–27]. EGFR tyrosine kinase activation leads to activation of numerous of intracellular signals, which bring to an end in processes that are critical to tumor progression, including cell growth, epithelial-mesenchymal transition (EMT), metastasis, and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC)

Zhang

Cai

et al. 2016

Oncotarget

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Hsa-miRNA-875-5p (miR-875-5p) has recently been discovered to have anticancer efficacy in different organs. However, the role of miR-875-5p on colorectal carcinoma (CRC) is still ambiguous. In this study, we investigated the role of miR-875-5p on the development of CRC. The results indicated that miR-875-5p was significantly down-regulated in primary tumor tissues and very low levels were found in CRC cell lines. Ectopic expression of miR-875-5p in CRC cell lines significantly suppressed cell growth as evidenced by cell viability assay, colony formation assay and BrdU staining, through inhibition of cyclin D1, cyclin D2, CDK4 and up-regulation of p57(Kip2) and p21(Waf1/Cip1). In addition, miR-875-5p induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein Bcl2. Moreover, miR-875-5p inhibited cellular migration and invasiveness through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. Further, oncogene EGFR was revealed to be a putative target of miR-875-5p, which was inversely correlated with miR-875-5p expression in CRC. Taken together, our results demonstrated that miR-875-5p played a pivotal role on CRC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic EGFR.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC)

Zhang

Cai

et al. 2016

Oncotarget

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“…It has been reported that OPCs can affect the immune system, which in turn can alter the differentiation and subversion of abnormal cells, thereby assessing the risk of cancer. Natural killer (NK) cells are an important component of the immune system and can interfere with tumor-and virus-infected cells, and the risk of cancer and infection can increase if the function of NK cells is impaired [60]. In this context, OPCs can disrupt the function of NK cells by activating MAPKs.…”

Section: Organophosphorus Compound-induced Cancer Is Mediated By Mapkmentioning

confidence: 99%

Organophosphorus Compounds and MAPK Signaling Pathways

Farkhondeh

Buhrmann

Pourbagher‐Shahri

et al. 2020

IJMS

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The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission of extracellular signals into the cell nucleus, leading to cell differentiation, cell growth, and apoptosis. Moreover, exposure to OPCs induces ERK, JNK, and p38-MAPK activation, which leads to oxidative stress and apoptosis in various tissues. However, the activation of MAPK signaling pathways may differ depending on the type of OPCs and the type of cell exposed. Finally, different cell responses can be induced by different types of MAPK signaling pathways after exposure to OPCs.

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“…A pesticide and xenobiotic named endosulfan promoted colon inflammation with concomitant upregulation of β-catenin and interleukin-6 expression ( 51 ). Another interesting report showed that the pesticide chlorpyrifos activates the EGFR/ERK1/2 growth signaling pathway to promote CRC development ( 52 ). These facts may suggest the hypothesis that at least some pesticides act as tumor promoters in the rapidly dividing colonic epithelial cell population ( 53 ).…”

Section: Potential Mechanisms Of How Pesticides Alter the CC And Crc mentioning

confidence: 99%

A Perspective Discussion on Rising Pesticide Levels and Colon Cancer Burden in Brazil

Uyemura

Stopper

Martin

et al. 2017

Front. Public Health

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Agriculture is a mainstay of many developing countries’ economy, such as Brazil. According to the Food and Agriculture Organization of the United Nations, Brazil is the major global consumer of pesticides. Irrespective of the fact that the International Agency for Research on Cancer suggests that pesticides promote human cancer risk, a prospective study reports that colorectal cancer (CRC) burden will increase in developing countries by approximately 60% in the coming decades. Here, we review the literature and public data from the Brazilian Federal Government to explore why pesticides levels and new cases of colon cancer (CC) are rising rapidly in the country. CC incidence is the second most common malignancy in men and women in the South and the Southeast of Brazil. However, while these regions have almost doubled their pesticide levels and CC mortality in 14 years, the amount of sold pesticides increased 5.2-fold with a corresponding 6.2-fold increase in CC mortality in Northern and Northeastern states. Interestingly, mortality from endocrine, nutritional, and metabolic diseases are rapidly increasing, in close resemblance with the pesticide detection levels in food. Taken together, we discuss the possibility that pesticides might alter the risk of CC.

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Chlorpyrifos promotes colorectal adenocarcinoma H508 cell growth through the activation of EGFR/ERK1/2 signaling pathway but not cholinergic pathway

Cited by 27 publications

References 52 publications

Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC)

Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC)

Organophosphorus Compounds and MAPK Signaling Pathways

A Perspective Discussion on Rising Pesticide Levels and Colon Cancer Burden in Brazil

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