2007
DOI: 10.1016/j.taap.2006.10.008
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Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility

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Cited by 66 publications
(39 citation statements)
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“…These observations could be related to Gearhart's study that showed that chlorpyrifos inhibit kinesin-dependent microtubule motility and Grigoryan's study that showed a tubulin polymerization disruption by chlorpyrifos oxon [22], [23]. As a consequence, proteins synthetized and involved in tight junction formation might be restrained to the cytoplasmic space rather than moving along microtubules to tight junction space.…”
Section: Discussionmentioning
confidence: 72%
“…These observations could be related to Gearhart's study that showed that chlorpyrifos inhibit kinesin-dependent microtubule motility and Grigoryan's study that showed a tubulin polymerization disruption by chlorpyrifos oxon [22], [23]. As a consequence, proteins synthetized and involved in tight junction formation might be restrained to the cytoplasmic space rather than moving along microtubules to tight junction space.…”
Section: Discussionmentioning
confidence: 72%
“…In addition, MRI studies have shown that 14-day exposures to 3 and 18 mg/kg/d CPF reduced brain AChE activity by 60–80% in rats and significantly decreased axonal transport of Mn 2+ , both at the end of the exposure period and after a 30-day washout period (Hernandez et al, 2015). CPF-induced impairments in axonal transport can partially be explained by altered motility of mitochondria and changes in motor proteins like kinesin and microtubules, as well as motor-associated proteins like tubulin (Gearhart et al, 2007; Prendergast et al, 2007; Grigoryan and Lockridge, 2009; Middlemore-Risher et al, 2011). Similar impairments in motor proteins are induced by DFP exposure, which may also impair axonal transport (Gearhart et al, 2007; Gao et al, 2016).…”
Section: Mechanisms Of Chronic Op Neurotoxicitymentioning
confidence: 99%
“…The dissection protocol described by Gearhart et al (2007) was used to isolate six brain regions-basal forebrain, hippocampus (anterior and posterior), striatum, prefrontal cortex, and cortex-from frozen half brains (collected above). Brain regions were manually homogenized using a polypropylene pestle in a 1.5-ml microcentrifuge tube (Scienceware catalog no.…”
Section: Homogenization Of Brain For Enzyme Assaysmentioning
confidence: 99%