Chlorpromazine Overcomes Temozolomide Resistance in Glioblastoma by inhibiting Cx43 and Essential DNA Repair Pathways
Paola Matarrese,
Michele Signore,
Barbara Ascione
et al.
Abstract:Background
In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM therapy in addition to temozolomide, the first-line standard of care. We previously demonstrated the antitumor efficacy of chlorpromazine and its synergistic effects with temozolomide in suppressing GBM cell malignant features in vitro. This prompted us to accomp… Show more
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