Chlorpromazine in Thalamic Pain Syndrome

Margolis, Lester H.; Gianascol, Alfred J.

doi:10.1212/wnl.6.4.302

Cited by 13 publications

(2 citation statements)

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“…Neuroleptics were first reported to have analgesic effects in the 1950s in various pain states, including peripheral neuropathic pain and central pain [37–39]. The adverse effects of long‐term neuroleptic drug treatment have, understandably, led to a reluctance to use these agents for the treatment of chronic pain for periods of months or years.…”

Section: Pharmacologic Treatmentsmentioning

confidence: 99%

Treatment of Neuropathic Pain: Historical Aspects

Scadding

2004

Pain Med

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Section: Pharmacologic Treatmentsmentioning

confidence: 99%

Treatment of Neuropathic Pain: Historical Aspects

Scadding

2004

Pain Med

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“…In one controlled study, amitriptyline was shown to have some pain ameliorating effect on CPSP patients (5). Phenothiazines (chlorpromazine) (25) and anticonvulsants (phenytoin [26,27] and carbamazepine [5]) are only minimally effective in reducing pain (17). Apomorphine has been reported to be effective but associated with significant adverse effects and a tendency to lose its effectiveness over time (28).…”

Section: Treatmentmentioning

confidence: 99%

Thalamic or Central Pain States Poststroke

Teasell¹

1996

Pain Research and Management

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Thalamic or central pain states are generally regarded as rare in stroke, occurring in fewer than 2% of patients. However, a recent study suggests that they may be more common, occurring in up to 8% of unselected stroke patients. Cerebrovascular lesions leading to central pain states do not necessarily involve the thalamus, but can occur following lower brainstem and suprathalamic lesions. Damage to the spinothalamocortical tract appears to be a prerequisite to the development of central poststroke pain (CPSP). Development of CPSP is likely related to denervation hyperexcitability of third or fourth order, thalamic or cortical neurons. Central pain is often described as a 'burning' sensation in association with an unpleasant association of tingling, pins and needles, or numbness. Spontaneous or evoked dysesthesia and allodynia/hyperalgesia are common. Central or thalamic pain is generally intractable to most therapeutic interventions. One case is presented to illustrate the typical clinical presentation of thalamic pain states and the difficulties in treating this pain.

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Phenothiazine und Azaphenothiazine als Heilmittel

Schenker¹,

Herbst

1963

Fortschritte Der Arzneimittelforschung / Progress in Drug Research / Progrès Des Recherches Pharmaceutiques

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Chlorpromazine in Thalamic Pain Syndrome

Cited by 13 publications

References 0 publications

Treatment of Neuropathic Pain: Historical Aspects

Treatment of Neuropathic Pain: Historical Aspects

Thalamic or Central Pain States Poststroke

Phenothiazine und Azaphenothiazine als Heilmittel

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