Chloroquine as a Malarial Suppressive: Absence of Visual Effects

Appleton, Budd; Wolfe, Martin S.; Mishtowt, George I.

doi:10.1093/milmed/138.4.225

Cited by 10 publications

(3 citation statements)

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“…Chloroquine is considered safe for use during pregnancy (51). The usual chemoprophylactic and therapeutic doses of chloroquine do not produce retinopathy (2). In contrast to quinine and quinidine, chloroquine does not produce hypoglycemia (10).…”

Section: Chloroquinementioning

confidence: 99%

Antimalarial agents: specific treatment regimens

Krogstad

Herwaldt

Schlesinger

1988

Antimicrob Agents Chemother

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Section: Chloroquinementioning

confidence: 99%

Antimalarial agents: specific treatment regimens

Krogstad

Herwaldt

Schlesinger

1988

Antimicrob Agents Chemother

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“…Viele Autoren, zum Beispiel Appleton (1973), Bruce-Chwatt (1977), die iiber Erfahrungen auf dem Gebiet der Malariaprophylaxe mit Chloroquun verfügen, betonen immer wieder, da sic noch keuner Netzhautschädigung bei regelrechter Anwendung des Chioroquins begegnet sind.…”

Section: Die Phase Der Intoxukation Wird In 5 Untergruppenunclassified

Augenschäden bei Langzeitprophylaxe der Malaria mit Chloroquin

Hj¹

1982

Klin Monatsbl Augenheilkd

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Several authors have reported corneal and retinal changes occurring during high-dosage application of chloroquine for the treatment of some internal and dermatological diseases (300-500 mg of the base daily). The critical limit seems to be application of a total of 100 g of the base of chloroquine. In malaria prophylaxis (300 mg of the base weekly) it will take six-and-a-half years to reach this limit. In the few reports (27 cases) of ocular damage following malaria prophylaxis, a hyperdosage became evident. People living for prolonged periods of time in areas where malaria is endemic should have regular ophthalmological examinations and the administration of chloroquine should be stopped at the slightest sign of ocular damage.

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“…Apart from chloroquine bad taste, side effects or intensify symptoms, as abdominal discomfort, nausea, vomiting, and diarrhea that may occur with primaquine (Goodman and Gilman, 2011). Retinal injury occurs by chloroquine high doses in rheumatoid arthritis treatment, didn't occur with the weekly doses for malaria, but chloroquine may be safe in pregnancy (Appleton et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

Epidemic Malaria: Is It Threatening to Egypt With the Travelers and Immigrants Through the Southern Borders

MORSY,

EL BAHNASAWY,

DAHESH

et al. 2023

Journal of the Egyptian Society of Parasitology

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Malaria is a serious and sometimes fatal disease caused by Plasmodium species that infects Anopheles mosquito which feeds on humans. But, as malaria parasites live in the RBC, infection also occur by blood transfusion, organ transplantation, shared contaminated needles or stickinjury, and placental transmission with perinatal outcomes such as stillbirth, low birth weight, preterm birth, and small-for-gestational-age neonates. Malaria patients are typically very sick with high fevers, shaking chills, and flu-like illness; but these symptoms may be mild and difficult to diagnose malaria. The severe infection may cause kidney failure, seizures, mental confusion, coma, and death. Man is infected by P. falciparum, P. vivax, P. ovale subspecies, P. malariae, & P. knowlesi, with P. falciparum results in severe infections, which may be miss-diagnosed with zoonotic babesiosis. Although malaria can be a deadly disease, illness and death from malaria can usually be prevented.Nowadays, migrants from endemic countries constitute a high proportion of imported malaria cases in non-endemic countries

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Chloroquine as a Malarial Suppressive: Absence of Visual Effects

Cited by 10 publications

References 0 publications

Antimalarial agents: specific treatment regimens

Antimalarial agents: specific treatment regimens

Augenschäden bei Langzeitprophylaxe der Malaria mit Chloroquin

Epidemic Malaria: Is It Threatening to Egypt With the Travelers and Immigrants Through the Southern Borders

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