Chloropyrimidines as a new class of antimicrobial agents

New Small-Molecule Synthetic Antimycobacterials

“…This represents an attractive hit based on low molecular weight, low clogP, and ease of synthesis. Additionally, these compounds were shown to be highly specific for M. tuberculosis, with only weak activity observed against other bacteria and fungi (1). No toxicity data have been reported.…”

Crystal structure of 2-[(4-fluorobenzyl)sulfanyl]-4-(2-methylpropyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile, C16H16FN3OS

“…A large number of pyrimidine-based antimetabolites are currently used as potent and selective anticancer activity [10][11][12]. In addition, marked antibacterial and antifungal activities were observed for several pyrimidine-5-carbonitrile derivatives [13][14][15][16][17]. Here, we report the crystal structure of the recently synthesized [16] title compound (C 16 H 16 FN 3 OS).…”

Crystal structure of 6-oxo-4-propyl-2-(propylthio)-1,6-dihydropyrimidine-5-carbonitrile, C11H15N3OS

“…Large array of pyrimidine-based analogues have emerged as useful therapies against human immunode ciency viruses (HIV) [5][6][7][8], hepatitis B viruses (HBV) [9], herpes simplex viruses (HSV) [10,11], in uenza viruses [12] and varicella-zoster virus (VZV) [13]. Moreover, several pyrimidine derivatives were reported to display antibacterial [14][15][16][17] and antifungal [18] activities. Taking into consideration the diverse chemotherapeutic properties of pyrimidine-5-carbonitrile derivatives, we report herein the synthesis and the crystal structure of the title compound.…”