Chlorophyll: The active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro

Lai, Chiu-Nan

doi:10.1080/01635587909513623

Cited by 64 publications

(30 citation statements)

References 5 publications

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“…The different cutting times did not have any statistically significant effect on °Brix values. The elements found in wheatgrass juice were similar to as reported earlier, such as 230.9 mg of Ca, 229.9 mg of Mg, 720.2 mg of P, 1406.6 mg of K, 98.7 mg of Na and 3.04 mg of Zn in 1 litre of wheatgrass juice (Lai, 1979). Benincasa et al (2014) reported total phenol content of approximately 800 GAE/g FW in a 12-day old wheatgrass cultivar (T. durum cv.…”

Section: Colour Values Of Grass Juice Samplessupporting

confidence: 66%

“…Wheatgrass contains vitamins C and E, β-carotene, ferulic acid and vanillic acid (Hanninen et al, 1999). Chlorophyll, one of the active components in the wheatgrass extract, was found to be responsible for inhibition of metabolic activation of carcinogens (Lai, 1979). There are various studies that attribute the benefits (mainly anti-cancer effects) of wheatgrass juice to its high chlorophyll content.…”

Section: Colour Values Of Grass Juice Samplesmentioning

confidence: 99%

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The Comparison of the Chemical Composition, Sensory, Phenolic and Antioxidant Properties of Juices from Different Wheatgrass and Turfgrass Species

Özköse

Arslan

Acar

2016

Not Bot Horti Agrobo

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Wheatgrass juice is mainly derived from the common wheat Triticum aestivum L. The present study focused on the analysis of the potential of different perennial turfgrass species in grass juice production by determining certain compositional characteristics. The effects of fertilisers on the plants and the cutting time on some chemical constituents and antioxidant potential of grass juices were addressed. The juices from the different species of grasses, such as T. durum, T. aestivum, Lolium perenne L., Festuca arundinacea Schreb. were obtained by pressing. DPPH (1, 1diphenyl-2-picrylhydrazyl) radical scavenging activity, elemental composition, total chlorophylls, total carotenes, tocopherols, vitamin C, total phenols, viscosity and the colour profiles of the grass juice samples were analysed. Water-soluble dry matter, protein, total phenols, flavonoids and vitamin E (especially Durum cultivar) content were found to be higher in the juices of Triticum species as compared to the other grasses. Turfgrass species demonstrated higher concentrations of oil (in grass), vitamin C (unfertilised samples), chlorophyll (except L. perenne local) and major elements. The pressing of turfgrass was an easy process. Such perennial grass varieties have advantages over the Triticum species in terms of having higher concentrations of vitamin C (unfertilised samples) and major elements. The results of sensory analysis suggested that L. perenne (cultivar) is the most promising cultivar in terms of obtaining pressed grass juice.

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Section: Colour Values Of Grass Juice Samplessupporting

confidence: 66%

Section: Colour Values Of Grass Juice Samplesmentioning

confidence: 99%

The Comparison of the Chemical Composition, Sensory, Phenolic and Antioxidant Properties of Juices from Different Wheatgrass and Turfgrass Species

Özköse

Arslan

Acar

2016

Not Bot Horti Agrobo

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“…1988;Negishi et al, 1989;Warner et al, 1991;Dashwood et al, 19911. In the Salmonella assay, the antimutagenic activity associated with several vegetable extracts has been shown to correlate with the chlorophyll contents [Lai, 1979;Lai et al, 19801. Both chlorophyll and sodium/copper chlorophyllin (CHL) inhibit the genotoxic activity of in Drosoplzila [Negishi et al.…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic potency of chlorophyllin in the salmonella assay and its correlation with binding constants of mutagen‐inhibitor complexes

Dashwood

Guo

1993

Environ and Mol Mutagen

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Chlorophyllin (CHL) is a water-soluble salt of chlorophyll that exhibits antimutagenic activity in short-term genotoxicity assays and inhibits carcinogen-DNA binding in vivo. The antimutagenic potency of CHL was studied against several structurally related heterocyclic amines using the Salmonella assay. The mutagens included 2-amino-3-methylimidazo[4,5,-f]-quinoline (IQ) and seven related IQ-type compounds, and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and three additional non-IQ-type compounds. No relationship was observed between mutagenic potency (revertants/ng mutagen) and antimutagenic potency when expressed in terms of the CHL dose/plate-inhibiting mutagenicity by 50 percent (I50). However, a correlation was observed between mutagenic potency and the mole ratio of CHL to mutagen giving 50% inhibition (MR50), with most mutagens requiring several hundredfold to several thousandfold molar excess of CHL for inhibition. In spectrophotometric studies, CHL formed noncovalent molecular complexes with the heterocyclic amines, with binding constants in the range 3-13 x 10(3) M-1. Binding constants were inversely correlated with I50 and MR50 values, i.e., with increasing strength of complex formation less CHL/plate and a lower mole ratio of CHL to mutagen was required to inhibit mutagenicity. The results support an inhibitory mechanism in which chlorophylls operate as "interceptor molecules," interacting with carcinogens and mutagens directly and limiting their bioavailability.

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“…Chlorophyll, though found to be antimutagenic in certain microbial test systems (Kimm et al, 1982;Lai, 1979;Negishi et al, 1989), induced a significant level of clastogenicity in our experiment with mice. Chlorophyll molecules are known to act as both electron acceptors and donors in charge transfer complexes (Katz et al, 1977).…”

Section: Mean Percentage Of Damaged Cells+ Standard Deviationmentioning

confidence: 57%

Comparison of the effects of crude extract of spinach‐beet leaves and equivalent amounts of chlorophyll and chlorophyllin in modifying the clastogenic activity of chromium (VI) oxide in mice in vivo

Sarkar

Sharma

Talukder

1995

Phytotherapy Research

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The anticlastogenic activities of a crude extract of leaves of spinach-beet (Beta vulgaris var. benghalensis Hort.) and equivalent amounts of chlorophyll extracted from the leaves and of synthetic chlorophyllin in reducing cytotoxicity were compared following exposure of mice in vivo to a known clastogen chromium (VI) oxide. Male Swiss albino mice were administered orally the vegetable extract for 7 consecutive days and then exposed to the clastogen by gavage (20 mg/kg b wt). For comparison, equivalent amounts of extracted chlorophyll and synthetic chlorophyllin were administered to the mice, 2 h before exposure to the same dose of the metal. Chromosomes were studied from bone marrow cells 24 h after exposure, following colchicine-hypotonic-fixative-flame dryingGiemsa staining schedule. Chlorophyllin and the crude extract, when given alone, did not induce chromosomal aberrations and reduced the clastogenic effects induced by chromium (VI) oxide to a statistically significant level, indicating a protective action. Chlorophyll, however, produced a significant increase of chromosomal aberrations compared with control, when administered alone and was not able to reduce the clastogenicity of the metallic salt to a significant level.

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Chlorophyll: The active factor in wheat sprout extract inhibiting the metabolic activation of carcinogens in vitro

Cited by 64 publications

References 5 publications

The Comparison of the Chemical Composition, Sensory, Phenolic and Antioxidant Properties of Juices from Different Wheatgrass and Turfgrass Species

The Comparison of the Chemical Composition, Sensory, Phenolic and Antioxidant Properties of Juices from Different Wheatgrass and Turfgrass Species

Antimutagenic potency of chlorophyllin in the salmonella assay and its correlation with binding constants of mutagen‐inhibitor complexes

Comparison of the effects of crude extract of spinach‐beet leaves and equivalent amounts of chlorophyll and chlorophyllin in modifying the clastogenic activity of chromium (VI) oxide in mice in vivo

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