Chlorophyll encapsulation by complex coacervation and vibration nozzle technology: Characterization and stability study

Agarry, Israel Emiezi; Wang, Zhirong; Cai, Tian; Kan, Jianquan; Chen, Kewei

doi:10.1016/j.ifset.2022.103017

Cited by 15 publications

(4 citation statements)

References 39 publications

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“…1 b). The rise in ζ-potential in the modulus after FD and SD could be a reflection of reconfiguration in the surface coverage and the broader unfolding of anionic groups during the drying process ( Agarry, Wang, Cai, Kan, et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

“…Chl is a main photosynthetic pigment; it can transfer light energy to a chemical receptor via alterations in its molecular structure. Thus, its structural stability can be evaluated by the amount of Chl remaining after exposure to light ( Agarry, Wang, Cai, Kan, et al, 2022 ). following 3-week exposure of unencapsulated Chl to sunlight at room temperature, only 1.84 % of free Chl was retained, while FDM and SDM showed significant (p < 0.05) protection for Chl with 38.12 % and 29.38 % at the end of the same period ( Fig.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative analysis of freeze drying and spray drying methods for encapsulation of chlorophyll with maltodextrin and whey protein isolate

Ledari,

Milani,

Shahidi

et al. 2024

Food Chemistry: X

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Comparative analysis of freeze drying and spray drying methods for encapsulation of chlorophyll with maltodextrin and whey protein isolate

Ledari,

Milani,

Shahidi

et al. 2024

Food Chemistry: X

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“…Chlorophylls are prone to structural modifications when exposed to external factors such as pH, enzymatic action, and oxidation. To mitigate the instability of chlorophyll outside its natural environment, different microencapsulation techniques, such as spray drying, complex coalescence, and microfluidization, have been used [52,99,100]. During digestion, chlorophyll is susceptible to transformations, especially on C-132, C-173, chelate and porphyrin structures.…”

Section: Other Effectsmentioning

confidence: 99%

The Structure, Functions and Potential Medicinal Effects of Chlorophylls Derived from Microalgae

Sun,

Wu,

et al. 2024

Marine Drugs

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Microalgae are considered to be natural producers of bioactive pigments, with the production of pigments from microalgae being a sustainable and economical strategy that promises to alleviate growing demand. Chlorophyll, as the main pigment of photosynthesis, has been widely studied, but its medicinal applications as an antioxidant, antibacterial, and antitumor reagent are still poorly understood. Chlorophyll is the most important pigment in plants and algae, which not only provides food for organisms throughout the biosphere, but also plays an important role in a variety of human and man-made applications. The biological activity of chlorophyll is closely related to its chemical structure; its specific structure offers the possibility for its medicinal applications. This paper reviews the structural and functional roles of microalgal chlorophylls, commonly used extraction methods, and recent advances in medicine, to provide a theoretical basis for the standardization and commercial production and application of chlorophylls.

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“…The mixtures were moved to a thermodynamic water bath shaker (JULABO™, Julabo Labortechnik GMBH, Seelbach, Germany) for continuous shaking at a shaking speed of 100 rpm at room temperature for three days, then centrifuged at 5000 rpm for 25 min. The supernatant was diluted with methanol using a magnetic stirrer at 500 rpm for 2 min at room temperature and then subjected to the quantification of SA content spectrophotometrically at 322 nm [32].…”

Section: Solubility Studiesmentioning

confidence: 99%

Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with Improved Antiviral Efficacy against SARS-CoV-2

Alhadrami,

El-Din,

Hassan

et al. 2023

Pharmaceutics

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This study aimed to develop a self-nanoemulsifying drug delivery system (SNE) for sinapic acid (SA) to improve its solubility and antiviral activity. Optimal components for the SA-SNE formulation were selected, including Labrafil as the oil, Cremophor EL as the surfactant, and Transcutol as the co-surfactant. The formulation was optimized using surface response design, and the optimized SA-SNE formulation exhibited a small globule size of 83.6 nm, high solubility up to 127.1 ± 3.3, and a 100% transmittance. In vitro release studies demonstrated rapid and high SA release from the formulation. Pharmacokinetic analysis showed improved bioavailability by 2.43 times, and the optimized SA-SNE formulation exhibited potent antiviral activity against SARS-CoV-2. The developed SA-SNE formulation can enhance SA’s therapeutic efficacy by improving its solubility, bioavailability, and antiviral activity. Further in silico, modeling, and Gaussian accelerated molecular dynamics (GaMD)-based studies revealed that SA could interact with and inhibit the viral main protease (Mpro). This research contributes to developing effective drug delivery systems for poorly soluble drugs like SA, opening new possibilities for their application via nebulization in SARS-CoV-2 therapy.

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Chlorophyll encapsulation by complex coacervation and vibration nozzle technology: Characterization and stability study

Cited by 15 publications

References 39 publications

Comparative analysis of freeze drying and spray drying methods for encapsulation of chlorophyll with maltodextrin and whey protein isolate

Comparative analysis of freeze drying and spray drying methods for encapsulation of chlorophyll with maltodextrin and whey protein isolate

The Structure, Functions and Potential Medicinal Effects of Chlorophylls Derived from Microalgae

Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with Improved Antiviral Efficacy against SARS-CoV-2

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