Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway

Kulyar, Muhammad Fakhar‐e‐Alam; Mo, Quan; Yao, Wangyuan; Ding, Yanmei; Zhang, Yan; Du, Hao; Pan, Huachun; Li, Kewei; Gao, Jindong; Shahzad, Muhammad; Mehmood, Khalid; Iqbal, Mudassar; Waqas, Muhammad; Akhtar, Muhammad Faheem; Bhutta, Zeeshan Ahmad; Li, Jiakui

doi:10.1016/j.phymed.2022.154296

Cited by 11 publications

(15 citation statements)

References 52 publications

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“…Moreover, it has been frequently mobilized to imitate TD in numerous research trials [ 14 , 22 , 44 ]. Our prior studies indicate that thiram induces apoptosis in chondrocytes, raising the number of apoptotic chondrocytes inside the osteogenesis area [ 27 , 45 ]. Besides, thiram inhibits angiogenesis within the GP, reducing chondrocytes function and osteogenesis [ 23 , 29 ].…”

Section: Growth Plate Associated Tibial Dyschondroplasia In Poultrymentioning

confidence: 99%

“…According to our previous studies, chlorogenic acid (CGA) in the feed may lower the prevalence of tibial dyschondroplasia as it targets specific mediators related to apoptotic events [ 12 , 26 , 27 , 45 , 124 ]. CGA is the most abundant phenolic acid in nature, being synthesized when quinic and caffeic acids are esterified.…”

Section: Prevention and Treatment Against Apoptotic Events Of Tdmentioning

confidence: 99%

“…It occurs naturally in various fruits, herbs, and vegetables, including kiwi fruit, coffee beans, tobacco leaves, and honeysuckle [ 125 ]. It has been seen in pharmacological trials to have significant antioxidant, anti-inflammatory, antiviral, anticancer, cardioprotective, anti-apoptotic, and free radical scavenging properties [ 27 , 45 , 126 , 127 ]. Zhang et al discovered that CGA might stimulate osteoblast growth and speed the S phase transition process.…”

Section: Prevention and Treatment Against Apoptotic Events Of Tdmentioning

confidence: 99%

“…Additionally, it may promote Bcl-2 expression and limit Bax activation during apoptosis, ultimately decreasing osteoblast apoptosis [ 128 ]. It has been shown in recent work by Kulyar et al that CGA has therapeutic benefits for TD chickens by modulating a variety of pathways associated with apoptosis and inflammasome [ 27 , 45 ]. Furthermore, targeting micro RNAs is a better therapy for overcoming such disorders.…”

Section: Prevention and Treatment Against Apoptotic Events Of Tdmentioning

confidence: 99%

“…Recent research has focused on the idea that, in contrast to pro-apoptotic, the anti-apoptotic approach in tibial dyschondroplasia may occasionally be advantageous as it reduces the inflammatory response [ 45 ]. In fact, an earlier regulation of apoptosis may be beneficial for chondrocytes’ survival.…”

Section: Prevention and Treatment Against Apoptotic Events Of Tdmentioning

confidence: 99%

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Regulatory Role of Apoptotic and Inflammasome Related Proteins and Their Possible Functional Aspect in Thiram Associated Tibial Dyschondroplasia of Poultry

Kulyar

Yao

et al. 2022

Animals

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Tibial dyschondroplasia debilities apoptotic and inflammasomal conditions that can further destroy chondrocytes. Inflammasomes are specialized protein complexes that process pro-inflammatory cytokines, e.g., interleukin-1β (IL-1β) and IL-18. Moreover, there is mounting evidence that many of the signaling molecules that govern programmed cell death also affect inflammasome activation in a cell-intrinsic way. During the last decade, apoptotic functions have been described for signaling molecules involving inflammatory responses and cell death pathways. Considering these exceptional developments in the knowledge of processes, this review gives a glimpse of the significance of these two pathways and their connected proteins in tibial dyschondroplasia. The current review deeply elaborates on the elevated level of signaling mediators of mitochondrial-mediated apoptosis and the inflammasome. Although investigating these pathways’ mechanisms has made significant progress, this review identifies areas where more study is especially required. It might lead to developing innovative therapeutics for tibial dyschondroplasia and other associated bone disorders, e.g., osteoporosis and osteoarthritis, where apoptosis and inflammasome are the significant pathways.

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